(Q48775974)

15 February 2018

title

Forging the links between metabolism and carcinogenesis. (English)

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15 February 2018

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F P Guengerich

1

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15 February 2018

language of work or name

English

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publication date

1 July 2001

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15 February 2018

published in

Mutation Research

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15 February 2018

volume

488

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15 February 2018

issue

3

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15 February 2018

page(s)

195-209

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15 February 2018

The role of metabolism in chemical mutagenesis and chemical carcinogenesis

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7 January 2021

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Chemical Production of Mutations

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Genetical Implications of the Structure of Deoxyribonucleic Acid

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Complementary base pairing and the origin of substitution mutations

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Identification by UV resonance Raman spectroscopy of an imino tautomer of 5-hydroxy-2'-deoxycytidine, a powerful base analog transition mutagen with a much higher unfavored tautomer frequency than that of the natural residue 2'-deoxycytidine

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The Detection of Chemical Mutagens with Enteric Bacteria

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7 January 2021

Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection

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7 January 2021

Identifying Environmental Chemicals Causing Mutations and Cancer

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7 January 2021

Ranking possible carcinogenic hazards

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Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP.

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7 January 2021

Response: do short-term tests predict rodent carcinogenicity?

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7 January 2021

Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.

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7 January 2021

Variations in aryl hydrocarbon hydroxylase activities in mitogen-activated human and nonhuman primate lymphocytes

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7 January 2021

Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.

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7 January 2021

Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[ a ]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography

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7 January 2021

Position-specific oxygenation of benzo(a)pyrene by different forms of purified cytochrome P-450 from rabbit liver

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7 January 2021

Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone

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7 January 2021

Highly purified cytochrome P-448 and P-450 from rat liver microsomes

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7 January 2021

Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism

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7 January 2021

Purification of human liver cytochrome P-450 and comparison to the enzyme isolated from rat liver

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7 January 2021

Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes

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7 January 2021

Polymorphic hydroxylation of Debrisoquine in man.

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7 January 2021

Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis

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7 January 2021

Molecular genetics of the P-450 superfamily

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7 January 2021

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver

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7 January 2021

Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1

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7 January 2021

Metabolic deactivation of furylfuramide by cytochrome P450 in human and rat liver microsomes.

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7 January 2021

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

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7 January 2021

Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylainine to products genotoxic in an acetyltransferase–overexpressing Salmonella typhimurium strain (NM2009)

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7 January 2021

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

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7 January 2021

Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays.

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7 January 2021

Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes.

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7 January 2021

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

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7 January 2021

Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice

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7 January 2021

Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes

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7 January 2021

Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes

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7 January 2021

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

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7 January 2021

Evidence for a role of a perferryl-oxygen complex, FeO3+, in the N-oxygenation of amines by cytochrome P450 enzymes

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7 January 2021

Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: substrate specificity with model substrates and promutagens

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7 January 2021

Baculovirus expression of bovine cytochrome P450c17 in Sf9 cells and comparison with expression in yeast, mammalian cells, and E. coli

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7 January 2021

New applications of bacterial systems to problems in toxicology.

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7 January 2021

Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.

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7 January 2021

Drug metabolism by Escherichia coli expressing human cytochromes P450.

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7 January 2021

Metabolic activation of aromatic amine mutagens by simultaneous expression of human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli.

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7 January 2021

Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines

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7 January 2021

Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase.

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7 January 2021

Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay.

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7 January 2021

An enzyme from rat liver catalysing conjugations with glutathione

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7 January 2021

Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver.

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7 January 2021

Induction of Stomach Cancer in Rats and Mice by Halogenated Aliphatic Fumigants

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7 January 2021

The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathion in vitro

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7 January 2021

Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.

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7 January 2021

Polymerase blockage and misincorporation of dNTPs opposite the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione

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7 January 2021

Spectroscopic and thermodynamic characterization of the interaction of N7-guanyl thioether derivatives of d(TGCTG*CAAG) with potential complements.

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7 January 2021

Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes

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7 January 2021

Enhancement of Bacterial Mutagenicity of Bifunctional Alkylating Agents by Expression of Mammalian Glutathione S-Transferase

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7 January 2021

A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system.

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7 January 2021

Metabolism of Polycyclic Aromatic Hydrocarbon Derivatives to Ultimate Carcinogens During Lipid Peroxidation

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7 January 2021

Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro

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7 January 2021

Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication

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7 January 2021

Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases

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7 January 2021

Conjugation of Highly Reactive Aflatoxin B1exo-8,9-Epoxide Catalyzed by Rat and Human Glutathione Transferases: Estimation of Kinetic Parameters†

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7 January 2021

Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase.

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7 January 2021

Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis

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7 January 2021

Studies on the detoxication of microsomally-activated aflatoxin B1 by glutathione and glutathione transferases in vitro.

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7 January 2021

Isolation and characterization of the major serum albumin adduct formed by aflatoxin B1 in vivo in rats

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7 January 2021

A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant

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7 January 2021

Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts

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7 January 2021

Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1

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7 January 2021

Biochemical Mechanisms and Pathobiology of α2u-Globulin Nephropathy

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7 January 2021

p53 mutations in human cancers

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7 January 2021

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900059-X

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7 January 2021

1,N6 formation, mutagenicity and murine tumor induction as indicators of the generation of an electrophilic epoxide metabolite of the closely related carcinogens ethyl carbamate (urethane) and vinyl carbamate

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7 January 2021

Enzymatic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,N6-ethenoadenosine.

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7 January 2021

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

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7 January 2021

Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2.

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7 January 2021

Sex Steroid Induced Changes in Hepatic Enzymes

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7 January 2021

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes.

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7 January 2021

Growth hormone regulates expression of rat liver cytochrome P-450 15 beta at a pretranslational level

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7 January 2021

STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression.

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7 January 2021

Enzymatic activation of chemicals to toxic metabolites.

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7 January 2021

Metabolism of benzo(a)pyrene by isolated hepatocytes and factors affecting covalent binding of benzo(a)pyrene metabolites to DNA in hepatocyte and microsomal systems

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https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900059-X

7 January 2021

Characterization of Electron Transport Enzymes in the Envelope of Rat Liver Nuclei

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https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900059-X

7 January 2021

Role of CYP2E1 in the hepatotoxicity of acetaminophen

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https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900059-X

7 January 2021

Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900059-X

7 January 2021

The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects

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7 January 2021

10.1016/S1383-5742(01)00059-X

Identifiers

DOI

1 reference

15 February 2018

1 reference

15 February 2018