(Q50321414)

English

Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells.

scientific article published on 3 January 2018

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scholarly article

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells. (English)

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

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author name string

Chloé Sauzay

1

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Christophe Louandre

2

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Sandra Bodeau

3

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Frédéric Anglade

4

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Corinne Godin

5

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Zuzana Saidak

6

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Jean-Xavier Fontaine

7

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Cédric Usureau

8

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Nathalie Martin

9

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Roland Molinie

10

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Julie Pascal

11

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

François Mesnard

12

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Olivier Pluquet

13

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Antoine Galmiche

14

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

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publication date

3 January 2018

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

9

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

9

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

8400-8414

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

Endoplasmic Reticulum Stress and the Hallmarks of Cancer

1 reference

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22 May 2018

Translational control and the cancer cell response to stress

1 reference

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22 May 2018

mTOR Signaling in Growth, Metabolism, and Disease.

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22 May 2018

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

1 reference

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22 May 2018

Lipid peroxidation in cell death

1 reference

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22 May 2018

Adaptive Stress Responses During Tumor Metastasis and Dormancy

1 reference

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22 May 2018

Role of the unfolded protein response in tumor cell characteristics and cancer outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Alpha-foetoprotein (AFP): A multi-purpose marker in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Emerging role of mTOR in the response to cancer therapeutics

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22 May 2018

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.

1 reference

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22 May 2018

Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

New frontiers in translational control of the cancer genome

1 reference

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22 May 2018

Mechanisms of ferroptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Alpha-fetoprotein is a biomarker of unfolded protein response and altered proteostasis in hepatocellular carcinoma cells exposed to sorafenib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

pERK/pAkt phenotyping in circulating tumor cells as a biomarker for sorafenib efficacy in patients with advanced hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Analysis of drug combinations: current methodological landscape

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Proteostasis control by the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

The biology of proteostasis in aging and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Cellular differences in protein synthesis regulate tissue homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

New biological perspectives for the improvement of the efficacy of sorafenib in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Sorafenib enhances proteasome inhibitor-mediated cytotoxicity via inhibition of unfolded protein response and keratin phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Ferroptosis: an iron-dependent form of nonapoptotic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

EGFR activation is a potential determinant of primary resistance of hepatocellular carcinoma cells to sorafenib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Comprehensive analysis of kinase inhibitor selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

BAD, a proapoptotic member of the BCL2 family, is a potential therapeutic target in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Reprogramming mRNA translation during stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

22 May 2018

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

14 August 2018

SUnSET, a nonradioactive method to monitor protein synthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5823558

14 August 2018

Phase II study of sorafenib in patients with advanced hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29492203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.23843

1 reference

Europe PubMed Central

30 April 2018

http://europepmc.org/abstract/PMC/5823558

1 reference

Europe PubMed Central

3 March 2018

http://europepmc.org/abstract/PMC/5823558

1 reference

Europe PubMed Central

30 April 2018

http://europepmc.org/abstract/PMC/5823558

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