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mTOR Signaling in Growth, Metabolism, and Disease.
scientific article published on March 2017
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Europe PubMed Central
PMCID
5394987
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
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5 April 2020
title
mTOR Signaling in Growth, Metabolism, and Disease
(English)
1 reference
stated in
Europe PubMed Central
PMCID
5394987
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
author
David M. Sabatini
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2
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Europe PubMed Central
PMCID
5394987
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
author name string
Robert A Saxton
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
5394987
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
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5 April 2020
language of work or name
English
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publication date
1 March 2017
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Europe PubMed Central
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5394987
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
published in
Cell
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stated in
Europe PubMed Central
PMCID
5394987
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
volume
168
1 reference
stated in
Europe PubMed Central
PMCID
5394987
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
issue
6
1 reference
stated in
Europe PubMed Central
PMCID
5394987
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
page(s)
960-976
1 reference
stated in
Europe PubMed Central
PMCID
5394987
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
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Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis
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Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1
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Genome sequencing identifies a basis for everolimus sensitivity
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Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2
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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.
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TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
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23 June 2018
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
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The translational landscape of mTOR signalling steers cancer initiation and metastasis
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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
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23 June 2018
Target of rapamycin (TOR) in nutrient signaling and growth control
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23 June 2018
mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling
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23 June 2018
Regulation of immune responses by mTOR.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Activation of mTORC2 by association with the ribosome
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Structure of the human mTOR complex I and its implications for rapamycin inhibition.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
The Vam6 GEF controls TORC1 by activating the EGO complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Critical roles for the TSC-mTOR pathway in β-cell function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
mTOR regulates memory CD8 T-cell differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Regulation of TORC1 by Rag GTPases in nutrient response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
AMPK phosphorylation of raptor mediates a metabolic checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Extension of chronological life span in yeast by decreased TOR pathway signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Rheb binds and regulates the mTOR kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
The role of autophagy during the early neonatal starvation period
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Genetics: influence of TOR kinase on lifespan in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
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23 June 2018
Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
23 June 2018
Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
31 August 2018
Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
31 August 2018
PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
31 August 2018
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
31 August 2018
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5394987
retrieved
31 August 2018
Inhibition of the immune response by rapamycin, a new antifungal antibiotic
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28283069
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28283069
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Activity of rapamycin (AY-22,989) against transplanted tumors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28283069
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A role for mammalian target of rapamycin in regulating T cell activation versus anergy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28283069
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CELL.2017.02.004
1 reference
stated in
Europe PubMed Central
PMCID
5394987
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
PMCID
5394987
1 reference
stated in
Europe PubMed Central
PMCID
5394987
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
PubMed ID
28283069
1 reference
stated in
Europe PubMed Central
PMCID
5394987
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283069%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
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