(Q50793930)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

title

The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

author name string

Raymonde Szargel

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

Vered Shani

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

Fatimah Abd Elghani

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

Lucy N Mekies

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

Esti Liani

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

Ruth Rott

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

publication date

22 June 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

issue

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

page(s)

3476-3490

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

Recent advances in the genetics of Parkinson's disease

15 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

100 years of Lewy pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Genetic analysis of pathways to Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Parkin and PINK1: much more than mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Siah-1 facilitates ubiquitination and degradation of synphilin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

The machinery of macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Molecular determinants of selective clearance of protein inclusions by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Ubiquitin is phosphorylated by PINK1 to activate parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

After the banquet: mitochondrial biogenesis, mitophagy, and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Mitochondria removal by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Parkin interacts with Ambra1 to induce mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

A protein conjugation system essential for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

The role of synphilin-1 in synaptic function and protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

PINK1 is degraded through the N-end rule pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Guidelines for the use and interpretation of assays for monitoring autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Alterations in the common fragile site gene Parkin in ovarian and other cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

ARTS and Siah collaborate in a pathway for XIAP degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

A novel obesity model: synphilin-1-induced hyperphagia and obesity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Experimental LPS-induced cholestasis alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: a quantitative colocalization study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

Analysis of mitochondrial network by imaging: proof of technique in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW189

21 January 2018

Identifiers

DOI

10.1093/HMG/DDW189

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27334109%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

1 reference