(Q52360379)

30 April 2018

title

Biophysical Derangements in Genetic Cardiomyopathies. (English)

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30 April 2018

author name string

Melissa L Lynn

series ordinal

1

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30 April 2018

Sarah J Lehman

series ordinal

2

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30 April 2018

Jil C Tardiff

series ordinal

3

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30 April 2018

publication date

1 April 2018

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30 April 2018

published in

Heart failure clinics

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30 April 2018

volume

14

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30 April 2018

issue

2

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30 April 2018

page(s)

147-159

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30 April 2018

A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation

cites work

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The amino terminus of muscle tropomyosin is a major determinant for function

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Structure of co-crystals of tropomyosin and troponin

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Diastolic abnormalities in patients with hypertrophic cardiomyopathy: relation to magnitude of left ventricular hypertrophy.

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Tropomyosin crystal structure and muscle regulation

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Non-polymerizable tropomyosin: Preparation, some properties and F-actin binding

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Hypertrophic cardiomyopathy: A desensitized cardiac \-adrenergic system in the presence of normal plasma catecholamine concentrations

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Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy

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Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation

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12 December 2020

Effects of Levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and Ca2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart

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12 December 2020

Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy

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12 December 2020

Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere

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12 December 2020

Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament

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12 December 2020

Differential effects of the optical isomers of EMD 53998 on contraction and cytoplasmic Ca2+ in isolated ferret cardiac muscle.

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12 December 2020

Myocardial beta adrenoceptors and left ventricular function in hypertrophic cardiomyopathy

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12 December 2020

Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy

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12 December 2020

Sudden death due to troponin T mutations

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12 December 2020

Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function.

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12 December 2020

Calcium handling proteins in the failing human heart

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12 December 2020

Effects of protein kinase A phosphorylation on signaling between cardiac troponin I and the N-terminal domain of cardiac troponin C

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12 December 2020

Troponin and tropomyosin: proteins that switch on and tune in the activity of cardiac myofilaments

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12 December 2020

Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression

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12 December 2020

Regulation of contraction in striated muscle

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12 December 2020

Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T

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12 December 2020

Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy

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12 December 2020

Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle

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12 December 2020

Skeletal and cardiac muscle contractile activation: tropomyosin "rocks and rolls".

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12 December 2020

Deciphering the design of the tropomyosin molecule

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12 December 2020

Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region

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12 December 2020

Differential scanning calorimetric study of myosin subfragment 1 with tryptic cleavage at the N-terminal region of the heavy chain

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12 December 2020

Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.

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12 December 2020

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

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12 December 2020

Cardiomyopathic tropomyosin mutations that increase thin filament Ca2+ sensitivity and tropomyosin N-domain flexibility

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12 December 2020

Effects of two familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin

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12 December 2020

Ca(2+)-regulated structural changes in troponin

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12 December 2020

Increase in tension-dependent ATP consumption induced by cardiac troponin T mutation

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12 December 2020

Solution NMR structure of the junction between tropomyosin molecules: implications for actin binding and regulation

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12 December 2020

A review of levosimendan in the treatment of heart failure

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12 December 2020

The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation

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12 December 2020

Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation

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12 December 2020

Ca(2+) exchange with troponin C and cardiac muscle dynamics

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12 December 2020

Hypertrophic cardiomyopathy: the genetic determinants of clinical disease expression

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12 December 2020

Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T

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12 December 2020

Defining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complex

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12 December 2020

Gestalt-binding of tropomyosin to actin filaments.

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12 December 2020

Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models

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12 December 2020

Functional diversity among a family of human skeletal muscle myosin motors

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12 December 2020

The relationship between curvature, flexibility and persistence length in the tropomyosin coiled-coil

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12 December 2020

Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy

1 reference

12 December 2020

Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle: Insight into the Diversity of N-Terminal Recognition,

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12 December 2020

Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin

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12 December 2020

A model of calcium activation of the cardiac thin filament

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12 December 2020

Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy

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12 December 2020

Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity

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12 December 2020

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12 December 2020

The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C.

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12 December 2020

Population-based variation in cardiomyopathy genes

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12 December 2020

Familial hypertrophic cardiomyopathy related E180G mutation increases flexibility of human cardiac α-tropomyosin

1 reference

12 December 2020

A novel alpha-tropomyosin mutation associates with dilated and non-compaction cardiomyopathy and diminishes actin binding

1 reference

12 December 2020

α-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains

1 reference

12 December 2020

Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy

1 reference

12 December 2020

Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells

1 reference

12 December 2020

A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin

1 reference

12 December 2020

The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin

1 reference

12 December 2020

Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin

1 reference

12 December 2020

Structure and flexibility of the tropomyosin overlap junction

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12 December 2020

To understand muscle you must take it apart

1 reference

12 December 2020

Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy

1 reference

12 December 2020

PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils

1 reference

12 December 2020

The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C

1 reference

12 December 2020

Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.

1 reference

12 December 2020

Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin.

1 reference

12 December 2020

Diltiazem treatment for pre-clinical hypertrophic cardiomyopathy sarcomere mutation carriers: a pilot randomized trial to modify disease expression

1 reference

12 December 2020

Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies.

1 reference

12 December 2020

Targeting the sarcomere to correct muscle function

1 reference

12 December 2020

Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector

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12 December 2020

Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate

1 reference

12 December 2020

Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation

1 reference

12 December 2020

Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin.

1 reference

12 December 2020

The Rapidly Evolving Role of Titin in Cardiac Physiology and Cardiomyopathy

1 reference

12 December 2020

Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.

1 reference

12 December 2020

Calcium sensitizers: What have we learned over the last 25 years?

1 reference

12 December 2020

Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial

1 reference

12 December 2020

β-adrenergic receptor signalling and its functional consequences in the diseased heart.

1 reference

12 December 2020

Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility

1 reference

12 December 2020

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

1 reference

12 December 2020

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.

1 reference

12 December 2020

Atomic resolution probe for allostery in the regulatory thin filament

1 reference

12 December 2020

A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies

1 reference

12 December 2020

Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres

1 reference

12 December 2020

Evolution of hypertrophic cardiomyopathy in sarcomere mutation carriers

1 reference

12 December 2020

Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy.

1 reference

12 December 2020

The Importance of Intrinsically Disordered Segments of Cardiac Troponin in Modulating Function by Phosphorylation and Disease-Causing Mutations

1 reference

12 December 2020

Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization

1 reference

12 December 2020

Structural and Functional Effects of Cardiomyopathy-Causing Mutations in the Troponin T-Binding Region of Cardiac Tropomyosin.

1 reference

12 December 2020

Myofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and Relaxation

1 reference

12 December 2020

Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration

1 reference

12 December 2020

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I.

1 reference

12 December 2020

Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery

1 reference

12 December 2020

The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy.

1 reference

12 December 2020

Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap.

1 reference

12 December 2020

Calcium and Excitation-Contraction Coupling in the Heart

1 reference

12 December 2020

Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models.

1 reference

12 December 2020

A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle

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12 December 2020

Cardiomyopathies: An Overview.

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12 December 2020

Dilated Cardiomyopathy: Genetic Determinants and Mechanisms.

1 reference

12 December 2020

Levosimendan in advanced heart failure: where do we stand?

1 reference

12 December 2020

Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region

1 reference

12 December 2020

Temporal Trends and Factors Associated With Cardiovascular Drug Development, 1990 to 2012.

1 reference

12 December 2020

10.1016/J.HFC.2017.12.002

Identifiers

DOI

1 reference

30 April 2018

release_im7z5ccspndhfbu4jiygsw4btq

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/im7z5ccspndhfbu4jiygsw4btq

24 November 2022

mapped directly with Wikidata item

PMC publication ID

6204208

0 references

1 reference

30 April 2018