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Necroptosis in development and diseases.
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1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
title
Necroptosis in development and diseases
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
main subject
necroptosis
1 reference
based on heuristic
inferred from title
author
Ayaz Najafov
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
author name string
Bing Shan
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
Heling Pan
series ordinal
2
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stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
Junying Yuan
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
publication date
1 March 2018
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
published in
Genes & Development
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
volume
32
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
issue
5-6
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Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
page(s)
327-340
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
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Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis
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Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis.
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MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis.
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MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation
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29 September 2018
RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice.
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Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death.
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ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
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RIPK1 inhibits ZBP1-driven necroptosis during development
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NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II.
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SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes
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The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
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29 September 2018
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
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29 September 2018
SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.
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IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.
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29 September 2018
An evolutionary perspective on the necroptotic pathway
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29 September 2018
K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo.
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29 September 2018
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
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29 September 2018
Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behçet's disease
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Paternal care and litter size coevolution in mammals.
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29 September 2018
NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions
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29 September 2018
Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
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29 September 2018
Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease.
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29 September 2018
LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes
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29 September 2018
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
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29 September 2018
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
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29 September 2018
NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis
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29 September 2018
NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.
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29 September 2018
The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis
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29 September 2018
Activation of necroptosis in multiple sclerosis
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29 September 2018
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
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29 September 2018
RIP3 induces apoptosis independent of pronecrotic kinase activity
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29 September 2018
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.
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29 September 2018
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
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PubMed Central
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29 September 2018
Necroptosis in health and diseases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
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29 September 2018
Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo
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29 September 2018
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
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29 September 2018
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.
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29 September 2018
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3
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29 September 2018
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.
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29 September 2018
Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
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29 September 2018
Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
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29 September 2018
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
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29 September 2018
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
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29 September 2018
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
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29 September 2018
CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
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29 September 2018
Control of life-or-death decisions by RIP1 kinase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
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29 September 2018
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
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29 September 2018
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Structural basis of RIP1 inhibition by necrostatins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Survival function of the FADD-CASPASE-8-cFLIP(L) complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Regulation of NF-κB by deubiquitinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Functional complementation between FADD and RIP1 in embryos and lymphocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Mutations of optineurin in amyotrophic lateral sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Necroptosis as an alternative form of programmed cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Antigen-mediated T cell expansion regulated by parallel pathways of death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Challenges in the use of allogeneic hematopoietic SCT for ectodermal dysplasia with immune deficiency.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Identification of RIP1 kinase as a specific cellular target of necrostatins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
The death domain superfamily in intracellular signaling of apoptosis and inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
A decade of caspases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Signalling pathways of the TNF superfamily: a double-edged sword
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
NF-kappaB signals induce the expression of c-FLIP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Apaf1 is required for mitochondrial pathways of apoptosis and brain development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
The pathophysiology of tumor necrosis factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
29 September 2018
A Dutch family with autosomal recessively inherited lower motor neuron predominant motor neuron disease due to optineurin mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900707
retrieved
30 November 2018
Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29593066
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Signature biomarkers in Crohn's disease: toward a molecular classification
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29593066
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
NEMO expression in human hepatocellular carcinoma and its association with clinical outcome
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29593066
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1101/GAD.312561.118
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PMC publication ID
5900707
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PubMed publication ID
29593066
1 reference
stated in
Europe PubMed Central
PMC publication ID
5900707
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29593066%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
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