(Q39044997)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

title

Necroptosis in development, inflammation and disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Douglas R. Green

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

author name string

Andrew Oberst

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Helen M Beere

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

publication date

21 December 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Molecular Cell Biology

30 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

page(s)

127-136

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrm.2016.149

30 March 2020

exact match

0 references

cites work

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

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The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene

31 March 2020

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Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways

31 March 2020

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Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

31 March 2020

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Caspase-independent cell killing by Fas-associated protein with death domain

31 March 2020

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

31 March 2020

1 reference

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Identification of RIP1 kinase as a specific cellular target of necrostatins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP3, a novel apoptosis-inducing kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

31 March 2020

1 reference

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Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Differential requirement for caspase 9 in apoptotic pathways in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

A role for FADD in T cell activation and development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Caspase activation is required for T cell proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

T cell-specific FADD-deficient mice: FADD is required for early T cell development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

An essential role for c-FLIP in the efficient development of mature T lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Antigen-mediated T cell expansion regulated by parallel pathways of death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Mechanisms of necroptosis in T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Functional complementation between FADD and RIP1 in embryos and lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Survival function of the FADD-CASPASE-8-cFLIP(L) complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

IAPs limit activation of RIP kinases by TNF receptor 1 during development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Protective roles for caspase-8 and cFLIP in adult homeostasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Butylated hydroxyanisole is more than a reactive oxygen species scavenger

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

TNF-alpha induces two distinct caspase-8 activation pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP3 induces apoptosis independent of pronecrotic kinase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK1- and RIPK3-induced cell death mode is determined by target availability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Regulation of inflammasome activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

A FADD-dependent innate immune mechanism in mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

A novel role for RIP1 kinase in mediating TNFα production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK3-mediated necroptosis promotes donor kidney inflammatory injury and reduces allograft survival.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

A role of RIP3-mediated macrophage necrosis in atherosclerosis development.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Activation of necroptosis in multiple sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Necroptosis, in vivo detection in experimental disease models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Necrostatin-1 ameliorates intracerebral hemorrhage-induced brain injury in mice through inhibiting RIP1/RIP3 pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Suppression of RIP3-dependent necroptosis by human cytomegalovirus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIP1/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Herpes simplex virus suppresses necroptosis in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Necroptosis takes place in human immunodeficiency virus type-1 (HIV-1)-infected CD4+ T lymphocytes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

A type III effector antagonizes death receptor signalling during bacterial gut infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Clostridium perfringens beta-toxin induces necrostatin-inhibitable, calpain-dependent necrosis in primary porcine endothelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Programmed necrosis in inflammation: Toward identification of the effector molecules

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Regulated necrosis: disease relevance and therapeutic opportunities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Virus inhibition of RIP3-dependent necrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Caspase 8 inhibits programmed necrosis by processing CYLD

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Ppm1b negatively regulates necroptosis through dephosphorylating Rip3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.149

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27999438

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27999438

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM.2016.149

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27999438%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference