(Q56453443)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29803629%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

title

The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation? (English)

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28 March 2020

0 references

1

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28 March 2020

4

John H Krystal

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28 March 2020

3

Ronald S Duman

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28 March 2020

2

Gerard Sanacora

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28 March 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29803629%20AND%20SRC:MED&resulttype=core&format=json

publication date

25 May 2018

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Pharmacology & Therapeutics

28 March 2020

published in

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28 March 2020

volume

190

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28 March 2020

page(s)

148-158

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Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

28 March 2020

cites work

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Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons.

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Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

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Limbic seizures increase neuronal production of messenger RNA for nerve growth factor

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12 December 2020

Distribution in the brain and metabolism of ketamine in the rat after intravenous administration

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12 December 2020

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments.

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12 December 2020

MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder

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Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia

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Hippocampal atrophy in recurrent major depression

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Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression

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Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG).

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12 December 2020

Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET)

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12 December 2020

Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex

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12 December 2020

Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers

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12 December 2020

A molecular and cellular theory of depression

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12 December 2020

Stress and hippocampal plasticity

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12 December 2020

Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

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12 December 2020

Antidepressant effects of ketamine in depressed patients

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12 December 2020

Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists.

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12 December 2020

The cellular neurobiology of depression

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Antidepressant-like actions of an AMPA receptor potentiator (LY392098).

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12 December 2020

Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments

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12 December 2020

Antidepressants and neuroplasticity

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12 December 2020

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12 December 2020

Cyloserine as an antidepressant agent

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12 December 2020

Glutamate as a therapeutic target in psychiatric disorders

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12 December 2020

Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects

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12 December 2020

Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders

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12 December 2020

Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS study

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12 December 2020

AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

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12 December 2020

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

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12 December 2020

The role of serendipity in drug discovery

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12 December 2020

Ketamine-associated ulcerative cystitis: a new clinical entity.

1 reference

12 December 2020

Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors

1 reference

12 December 2020

NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons

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12 December 2020

Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study

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12 December 2020

The loss of serendipity in psychopharmacology

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12 December 2020

Chronic riluzole treatment increases glucose metabolism in rat prefrontal cortex and hippocampus

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12 December 2020

Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

1 reference

12 December 2020

The molecular neurobiology of depression

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12 December 2020

An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.

1 reference

12 December 2020

The destruction of the lower urinary tract by ketamine abuse: a new syndrome?

1 reference

12 December 2020

Stress-induced changes in nucleus accumbens glutamate synaptic plasticity

1 reference

12 December 2020

Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation

1 reference

12 December 2020

Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory

1 reference

12 December 2020

Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory

1 reference

12 December 2020

Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists

1 reference

12 December 2020

A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression

1 reference

12 December 2020

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

1 reference

12 December 2020

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

1 reference

12 December 2020

Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine

1 reference

12 December 2020

IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity

1 reference

12 December 2020

Variable global dysconnectivity and individual differences in schizophrenia

1 reference

12 December 2020

Drug-induced liver injury following a repeated course of ketamine treatment for chronic pain in CRPS type 1 patients: a report of 3 cases

1 reference

12 December 2020

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

1 reference

12 December 2020

Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder

1 reference

12 December 2020

Ketamine use: a review

1 reference

12 December 2020

Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders

1 reference

12 December 2020

13C MRS studies of neuroenergetics and neurotransmitter cycling in humans

1 reference

12 December 2020

Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex

1 reference

12 December 2020

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

1 reference

12 December 2020

¹H-[¹³C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism

1 reference

12 December 2020

Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology.

1 reference

12 December 2020

Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial

1 reference

12 December 2020

Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex.

1 reference

12 December 2020

Stress during development alters dendritic morphology in the nucleus accumbens and prefrontal cortex

1 reference

12 December 2020

A pilot study of hippocampal volume and N-acetylaspartate (NAA) as response biomarkers in riluzole-treated patients with GAD.

1 reference

12 December 2020

Effects of inhibitor of κB kinase activity in the nucleus accumbens on emotional behavior.

1 reference

12 December 2020

Effects of ketamine in treatment-refractory obsessive-compulsive disorder

1 reference

12 December 2020

Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history

1 reference

12 December 2020

Synaptic dysfunction in depression: potential therapeutic targets

1 reference

12 December 2020

Stress-induced grey matter loss determined by MRI is primarily due to loss of dendrites and their synapses

1 reference

12 December 2020

Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review

1 reference

12 December 2020

A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression

1 reference

12 December 2020

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

1 reference

12 December 2020

Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans

1 reference

12 December 2020

Overlapping and segregated resting-state functional connectivity in patients with major depressive disorder with and without childhood neglect

1 reference

12 December 2020

Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver

1 reference

12 December 2020

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

1 reference

12 December 2020

From pathophysiology to novel antidepressant drugs: glial contributions to the pathology and treatment of mood disorders

1 reference

12 December 2020

Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses.

1 reference

12 December 2020

Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept

1 reference

12 December 2020

The impact of NMDA receptor blockade on human working memory-related prefrontal function and connectivity

1 reference

12 December 2020

The brain reward circuitry in mood disorders

1 reference

12 December 2020

Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial

1 reference

12 December 2020

Ketamine and imipramine in the nucleus accumbens regulate histone deacetylation induced by maternal deprivation and are critical for associated behaviors

1 reference

12 December 2020

Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects

1 reference

12 December 2020

Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

1 reference

12 December 2020

Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder.

1 reference

12 December 2020

Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial

1 reference

12 December 2020

A randomized controlled trial of intranasal ketamine in major depressive disorder

1 reference

12 December 2020

(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function.

1 reference

12 December 2020

Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress.

1 reference

12 December 2020

A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes

1 reference

12 December 2020

In vivo hippocampal subfield volumes in schizophrenia and bipolar disorder

1 reference

12 December 2020

In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5.

1 reference

12 December 2020

N-methyl-D-aspartate receptor antagonist effects on prefrontal cortical connectivity better model early than chronic schizophrenia

1 reference

12 December 2020

BDNF release is required for the behavioral actions of ketamine

1 reference

12 December 2020

Schizophrenia in the spectrum of gene-stress interactions: the FKBP5 example

1 reference

12 December 2020

Amygdala-hippocampal volume and the phenotypic heterogeneity of posttraumatic stress disorder: a cross-sectional study

1 reference

12 December 2020

Ketamine as a promising prototype for a new generation of rapid-acting antidepressants

1 reference

12 December 2020

Role of calcium, glutamate and NMDA in major depression and therapeutic application

1 reference

12 December 2020

Randomized proof of concept trial of GLYX-13, an N-methyl-D-aspartate receptor glycine site partial agonist, in major depressive disorder nonresponsive to a previous antidepressant agent

1 reference

12 December 2020

Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder

1 reference

12 December 2020

The positive effect on ketamine as a priming adjuvant in antidepressant treatment.

1 reference

12 December 2020

The distribution and clearance of (2S,6S)-hydroxynorketamine, an active ketamine metabolite, in Wistar rats

1 reference

12 December 2020

Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition.

1 reference

12 December 2020

A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder.

1 reference

12 December 2020

Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study

1 reference

12 December 2020

New targets for rapid antidepressant action

1 reference

12 December 2020

Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress-Induced Depressive Behaviors

1 reference

12 December 2020

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

1 reference

12 December 2020

A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression

1 reference

12 December 2020

KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID-ACTING ANTIDEPRESSANTS.

1 reference

12 December 2020

KETAMINE FOR TREATMENT-RESISTANT UNIPOLAR AND BIPOLAR MAJOR DEPRESSION: CRITICAL REVIEW AND IMPLICATIONS FOR CLINICAL PRACTICE.

1 reference

12 December 2020

Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

1 reference

12 December 2020

Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder

1 reference

12 December 2020

NMDAR inhibition-independent antidepressant actions of ketamine metabolites.

1 reference

12 December 2020

GABA interneurons mediate the rapid antidepressant-like effects of scopolamine

1 reference

12 December 2020

Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters.

1 reference

12 December 2020

Low-Dose d-Cycloserine for Depression?

1 reference

12 December 2020

Ketamine Treatment and Global Brain Connectivity in Major Depression

1 reference

12 December 2020

Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures

1 reference

12 December 2020

GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine.

1 reference

12 December 2020

Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study

1 reference

12 December 2020

Lamotrigine compared to placebo and other agents with antidepressant activity in patients with unipolar and bipolar depression: a comprehensive meta-analysis of efficacy and safety outcomes in short-term trials

1 reference

12 December 2020

Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies

1 reference

12 December 2020

Anterior hippocampal dysconnectivity in posttraumatic stress disorder: a dimensional and multimodal approach.

1 reference

12 December 2020

A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders

1 reference

12 December 2020

The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder

1 reference

12 December 2020

Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD.

1 reference

12 December 2020

Targeting glutamate signalling in depression: progress and prospects

1 reference

12 December 2020

Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression.

1 reference

12 December 2020

Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects

1 reference

12 December 2020

Ketamine's dose-related effects on anxiety symptoms in patients with treatment refractory anxiety disorders

1 reference

12 December 2020

Neurobiology of posttraumatic stress disorder (PTSD): A path from novel pathophysiology to innovative therapeutics

1 reference

12 December 2020

A Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Comparison Design Trial of Adjunctive Riluzole for Treatment-Resistant Major Depressive Disorder

1 reference

12 December 2020

Early Life Stress, Mood, and Anxiety Disorders

1 reference

12 December 2020

Rapid Acting Antidepressants in Chronic Stress Models: Molecular and Cellular Mechanisms

1 reference

12 December 2020

Neuroclinical Framework for the Role of Stress in Addiction

1 reference

12 December 2020

Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine

1 reference

12 December 2020

The Association of PTSD Symptom Severity with Localized Hippocampus and Amygdala Abnormalities

1 reference

12 December 2020

Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic.

1 reference

12 December 2020

Combat Exposure Severity is Associated with Reduced Cortical Thickness in Combat Veterans: A Preliminary Report

1 reference

12 December 2020

Ketamine for Social Anxiety Disorder: A Randomized, Placebo-Controlled Crossover Trial

1 reference

12 December 2020

Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder

1 reference

12 December 2020

The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis.

1 reference

12 December 2020

The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders

1 reference

12 December 2020

Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment

1 reference

12 December 2020

Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit

1 reference

12 December 2020

Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial

1 reference

12 December 2020

Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.

1 reference

12 December 2020

Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial

1 reference

12 December 2020

Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial

1 reference

12 December 2020

Ketamine for the treatment of addiction: Evidence and potential mechanisms.

1 reference

12 December 2020

Mapping the central effects of (±)-ketamine and traxoprodil using pharmacological magnetic resonance imaging in awake rats

1 reference

12 December 2020

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression.

1 reference

12 December 2020

Preclinical and Clinical Evidence of DNA Methylation Changes in Response to Trauma and Chronic Stress

1 reference

12 December 2020

The Neurobiological Mechanisms of Generalized Anxiety Disorder and Chronic Stress

1 reference

12 December 2020

Chronic Stress in Adolescents and Its Neurobiological and Psychopathological Consequences: An RDoC Perspective

1 reference

12 December 2020

The role of stress in the pathogenesis and maintenance of obsessive-compulsive disorder

1 reference

12 December 2020

Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study.

1 reference

12 December 2020

Efficacy, Safety, and Durability of Repeated Ketamine Infusions for Comorbid Posttraumatic Stress Disorder and Treatment-Resistant Depression.

1 reference

12 December 2020

Altered Cortical GABA in Female Veterans with Suicidal Behavior: Sex Differences and Clinical Correlates

1 reference

12 December 2020

Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from Molecular Imaging Studies

1 reference

12 December 2020

Early Life Stress Associated With Increased Striatal -Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass and Behavioral Correlates

1 reference

12 December 2020

Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine's Antidepressant Action.

1 reference

12 December 2020

10.1016/J.PHARMTHERA.2018.05.010

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29803629%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29803629%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

PubMed publication ID

29803629

1 reference