(Q56565594)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30046105%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

title

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30046105%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

main subject

visceral leishmaniasis

1 reference

1

1 reference

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30 August 2019

Manu De Rycker

5

1 reference

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30 August 2019

Michael D. Urbaniak

8

1 reference

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30 August 2019

Thomas D Otto

9

1 reference

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30 August 2019

Fabio Zuccotto

14

1 reference

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30 August 2019

Sébastien Albrecht

20

1 reference

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30 August 2019

David W. Gray

23

1 reference

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30 August 2019

Susan A Dixon

25

1 reference

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30 August 2019

Michael J. Ferguson

28

1 reference

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30 August 2019

Alan Fairlamb

29

1 reference

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30 August 2019

15

Nadine Homeyer

1 reference

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30 August 2019

10

Laste Stojanovski

1 reference

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30 August 2019

21

Matt Berriman

1 reference

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30 August 2019

27

Paul G Wyatt

1 reference

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30 August 2019

30

Timothy J Miles

1 reference

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30 August 2019

31

Kevin D Read

1 reference

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30 August 2019

32

Ian H Gilbert

1 reference

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30 August 2019

4

Sabrinia Crouch

1 reference

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30 August 2019

6

Rhiannon Lowe

1 reference

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30 August 2019

7

Stephanie Gresham

1 reference

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30 August 2019

12

Sujatha Manthri

1 reference

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30 August 2019

16

Hannah Pflaumer

1 reference

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30 August 2019

17

Markus Boesche

1 reference

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30 August 2019

18

Lalitha Sastry

1 reference

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30 August 2019

24

Sonja Ghidelli-Disse

1 reference

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30 August 2019

13

Lorna M MacLean

1 reference

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30 August 2019

26

Jose M Fiandor

1 reference

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30 August 2019

author name string

Michael Thomas

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30046105%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

Stephen Patterson

3

1 reference

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30 August 2019

Paul Connolly

19

1 reference

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30 August 2019

Gerard Drewes

22

1 reference

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30 August 2019

Frederick R C Simeons

11

1 reference

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30 August 2019

language of work or name

English

0 references

publication date

25 July 2018

1 reference

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30 August 2019

1 reference

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30 August 2019

volume

560

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30046105%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

issue

7717

1 reference

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30 August 2019

page(s)

192-197

1 reference

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https://scigraph.springernature.com/pub.10.1038/s41586-018-0356-z

30 August 2019

exact match

0 references

cites work

Leishmaniasis worldwide and global estimates of its incidence

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Royal Society of Tropical Medicine and Hygiene joint meeting with Médecins Sans Frontières at Manson House, London, 20 March 2003: field research in humanitarian medical programmes. Médecins Sans Frontières interventions against kala-azar in the Sud

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Developments in the treatment of visceral leishmaniasis

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Unresponsiveness to AmBisome in some Sudanese patients with kala-azar.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Target deconvolution strategies in drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

From noncovalent to covalent bonds: a paradigm shift in target protein identification

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Target identification for biologically active small molecules using chemical biology approaches

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Hide and seek: Identification and confirmation of small molecule protein targets

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Rational design of inhibitors that bind to inactive kinase conformations

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Identification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Pairwise knockdowns of cdc2-related kinases (CRKs) in Trypanosoma brucei identified the CRKs for G1/S and G2/M transitions and demonstrated distinctive cytokinetic regulations between two developmental stages of the organism

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Optimized chemical proteomics assay for kinase inhibitor profiling.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

In vitro and in vivo interactions between miltefosine and other antileishmanial drugs

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0356-Z

7 January 2021

Regulation of Leishmania populations within the host. I. the variable course of Leishmania donovani infections in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30046105

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41586-018-0356-Z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30046105%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30046105%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

PubMed publication ID

30046105

1 reference