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EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains
scientific article published on 28 January 2019
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30692681
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title
EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains
(English)
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Maria Donaldson
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Stéphanie Sungalee
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Daniele Tavernari
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Natalya Katanayeva
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Elena Battistello
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Kyle M Douglass
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Suliana Manley
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Giovanni Ciriello
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Elisa Oricchio
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Marie Zufferey
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20 April 2020
Marco Mina
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20 April 2020
Timo Rey
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9
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20 April 2020
Franck Raynaud
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28 January 2019
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Nature Genetics
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51
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3
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https://scigraph.springernature.com/pub.10.1038/s41588-018-0338-y
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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
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EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
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Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.
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A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping
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F-box protein FBXL2 inhibits gastric cancer proliferation by ubiquitin-mediated degradation of forkhead box M1
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7 January 2021
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1 reference
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UMI-4C for quantitative and targeted chromosomal contact profiling.
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7 January 2021
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10.1038/S41588-018-0338-Y
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PubMed publication ID
30692681
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30692681%20AND%20SRC:MED&resulttype=core&format=json
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20 April 2020
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PubMed publication ID
30692681
1 reference
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PubMed publication ID
30692681
reference URL
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20 April 2020
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