(Q73236875)

English

Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries

scientific article published on 01 December 1999

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scholarly article

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2 November 2019

Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries (English)

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2 November 2019

Staphylococcus aureus

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based on heuristic

inferred from title

5

object named as

N Osheroff

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2 November 2019

author name string

V E Anderson

1

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2 November 2019

R P Zaniewski

2

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2 November 2019

F S Kaczmarek

3

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2 November 2019

T D Gootz

4

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publication date

1 December 1999

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2 November 2019

Journal of Biological Chemistry

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2 November 2019

274

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2 November 2019

35927-35932

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2 November 2019

50

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2 November 2019

Fluoroquinolone antimicrobial agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Clinical applications of quinolones

1 reference

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21 January 2018

Fluoroquinolone antibacterials: SAR mechanism of action, resistance, and clinical aspects

1 reference

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21 January 2018

Bacterial topoisomerases, anti-topoisomerases, and anti-topoisomerase resistance.

1 reference

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21 January 2018

Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

1 reference

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21 January 2018

Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

1 reference

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21 January 2018

New topoisomerase essential for chromosome segregation in E. coli.

1 reference

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21 January 2018

Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones.

1 reference

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21 January 2018

Topoisomerase IV is a target of quinolones in Escherichia coli

1 reference

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21 January 2018

Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

1 reference

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21 January 2018

DNA gyrase as a drug target

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities.

1 reference

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21 January 2018

The twisted 'life' of DNA in the cell: bacterial topoisomerases

1 reference

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21 January 2018

DNA topoisomerases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

DNA gyrase: an enzyme that introduces superhelical turns into DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Escherichia coli DNA topoisomerase I mutants: Increased supercoiling is corrected by mutations near gyrase genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

DNA gyrase: structure and function.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Thermosensitive Mutants of E. coli Affected in the Processes of DNA Synthesis and Cellular Division

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Gene organization in the region containing a new gene involved in chromosome partition in Escherichia coli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

The molecular basis of quinolone action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Topoisomerase IV catalysis and the mechanism of quinolone action.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

The mechanism of inhibition of topoisomerase IV by quinolone antibacterials

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

DNA cloning and organization of the Staphylococcus aureus gyrA and gyrB genes: close homology among gyrase proteins and implications for 4-quinolone action and resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Cloning of the DNA gyrase genes under tac promoter control: overproduction of the gyrase A and B proteins

1 reference

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21 January 2018

Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Topoisomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potential

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Use of in vitro topoisomerase II assays for studying quinolone antibacterial agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

1 reference

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21 January 2018

Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

1 reference

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21 January 2018

Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H- pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)

1 reference

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21 January 2018

Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

DNA sequence selectivity of topoisomerases and topoisomerase poisons.

1 reference

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21 January 2018

Clinical applications of anticancer drugs targeted to topoisomerase II

1 reference

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21 January 2018

Apurinic sites are position-specific topoisomerase II poisons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35927

21 January 2018

The response of eukaryotic topoisomerases to DNA damage

1 reference

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21 January 2018

Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex

1 reference

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21 January 2018

Mechanism of quinolone action. A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV.

1 reference

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21 January 2018

Topoisomerase II-mediated DNA cleavage and religation in the absence of base pairing. Abasic lesions as a tool to dissect enzyme mechanism

1 reference

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21 January 2018

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1 reference

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21 January 2018

DNA topoisomerase II sites in the histone H4 gene during the highly synchronous cell cycle of Physarum polycephalum

1 reference

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21 January 2018

A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

1 reference

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21 January 2018

Identifiers

10.1074/JBC.274.50.35927

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10585479%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10585479%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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