(Q85657017)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25271708%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models (English)

1 reference

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20 February 2020

2

1 reference

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20 February 2020

Subhasree Nag

5

1 reference

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20 February 2020

10

John K Buolamwini

1 reference

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20 February 2020

11

Ruiwen Zhang

1 reference

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20 February 2020

9

Hui Wang

1 reference

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20 February 2020

1

Wei Wang

1 reference

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20 February 2020

author name string

Sukesh Voruganti

3

1 reference

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20 February 2020

Kalkunte S Srivenugopal

4

1 reference

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20 February 2020

Shivaputra Patil

6

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20 February 2020

Horrick Sharma

7

1 reference

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20 February 2020

Ming-Hai Wang

8

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20 February 2020

publication date

1 October 2014

1 reference

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20 February 2020

published in

Nature Communications

1 reference

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20 February 2020

volume

5

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20 February 2020

page(s)

5086

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https://scigraph.springernature.com/pub.10.1038/ncomms6086

20 February 2020

exact match

0 references

cites work

Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy

1 reference

12 December 2020

Stimulation of human DNA polymerase epsilon by MDM2

1 reference

12 December 2020

p53-independent activities of MDM2 and their relevance to cancer therapy

1 reference

12 December 2020

p53, the cellular gatekeeper for growth and division

1 reference

12 December 2020

Association of breast cancer outcome with status of p53 and MDM2 SNP309

1 reference

12 December 2020

Hallmarks of Cancer: The Next Generation

1 reference

12 December 2020

Natural product MDM2 inhibitors: anticancer activity and mechanisms of action.

1 reference

12 December 2020

MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

1 reference

12 December 2020

In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues.

1 reference

12 December 2020

Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination

1 reference

12 December 2020

A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action.

1 reference

12 December 2020

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

12 December 2020

A census of amplified and overexpressed human cancer genes

1 reference

12 December 2020

Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2.

1 reference

12 December 2020

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

12 December 2020

Recent advances in validating MDM2 as a cancer target.

1 reference

12 December 2020

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

1 reference

12 December 2020

Triple-negative breast cancer: disease entity or title of convenience?

1 reference

12 December 2020

Quantitative analysis of binding of transcription factor complex to biotinylated DNA probe by a streptavidin–agarose pulldown assay

1 reference

12 December 2020

Identification of ribosomal protein S25 (RPS25)-MDM2-p53 regulatory feedback loop.

1 reference

12 December 2020

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

1 reference

12 December 2020

Transcription factor NFAT1 activates the mdm2 oncogene independent of p53.

1 reference

12 December 2020

p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis

1 reference

12 December 2020

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

1 reference

12 December 2020

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

1 reference

12 December 2020

MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon

1 reference

12 December 2020

MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.

1 reference

12 December 2020

Triple-Negative Breast Cancer

1 reference

12 December 2020

New insights into the mechanisms of organ-specific breast cancer metastasis

1 reference

12 December 2020

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

12 December 2020

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

1 reference

12 December 2020

Targeting the MDM2-p53 interaction for cancer therapy

1 reference

12 December 2020

Small-molecule SMAC mimetics as new cancer therapeutics

1 reference

12 December 2020

Regulation of p53 stability by Mdm2

1 reference

12 December 2020

Targeting triple negative breast cancer: is p53 the answer?

1 reference

12 December 2020

Protein-protein interactions regulate Ubl conjugation

1 reference

12 December 2020

Murine double minute 2: p53-independent roads lead to genome instability or death

1 reference

12 December 2020

The benefits and harms of breast cancer screening: an independent review

1 reference

12 December 2020

Breast cancer assessment tools and optimizing adjuvant therapy.

1 reference

12 December 2020

Structure-based design of potent non-peptide MDM2 inhibitors

1 reference

12 December 2020

Breast cancer statistics, 2013.

1 reference

12 December 2020

siRNAs in drug discovery: target validation and beyond

1 reference

12 December 2020

Regulation of XIAP translation and induction by MDM2 following irradiation

1 reference

12 December 2020

A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation

1 reference

12 December 2020

Assessing TP53 status in human tumours to evaluate clinical outcome

1 reference

12 December 2020

Alternative and aberrant messenger RNA splicing of the mdm2 oncogene in invasive breast cancer

1 reference

12 December 2020

MDM2 oncogene as a novel target for human cancer therapy

1 reference

12 December 2020

Molecular mechanism of the interaction between MDM2 and p53.

1 reference

12 December 2020

Mdm2 promotes the rapid degradation of p53

1 reference

12 December 2020

Surfing the p53 network

1 reference

12 December 2020

MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy

1 reference

12 December 2020

Cancer statistics, 2014

1 reference

12 December 2020

Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis

1 reference

12 December 2020

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

1 reference

12 December 2020

Chest pain after emotional and physical upset.

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS6086

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCOMMS6086

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25271708%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 February 2020

ADS bibcode

2014NatCo...5.5086W

0 references

0 references

1 reference

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20 February 2020

1 reference