(Q37524156)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

review article

1 reference

title

Recent advances in validating MDM2 as a cancer target (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

author name string

Elizabeth R Rayburn

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Scharri J Ezell

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Ruiwen Zhang

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

publication date

1 October 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

Anti-Cancer Agents in Medicinal Chemistry

31 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

page(s)

882-903

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity

31 January 2020

cites work

1 reference

12 December 2020

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

12 December 2020

Overexpression of MDM2 in MCF-7 promotes both growth advantage and p53 accumulation in response to estradiol.

1 reference

12 December 2020

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.

1 reference

12 December 2020

A novel cofactor for p300 that regulates the p53 response

1 reference

12 December 2020

MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins

1 reference

12 December 2020

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

1 reference

12 December 2020

Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

1 reference

12 December 2020

Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis

1 reference

12 December 2020

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha

1 reference

12 December 2020

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

1 reference

12 December 2020

Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression

1 reference

12 December 2020

p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells

1 reference

12 December 2020

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

1 reference

12 December 2020

A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2

1 reference

12 December 2020

Different sensitivity of the transforming growth factor-beta cell cycle arrest pathway to c-Myc and MDM-2.

1 reference

12 December 2020

MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.

1 reference

12 December 2020

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

1 reference

12 December 2020

Strategies for manipulating the p53 pathway in the treatment of human cancer.

1 reference

12 December 2020

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

1 reference

12 December 2020

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

1 reference

12 December 2020

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

1 reference

12 December 2020

Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

1 reference

12 December 2020

Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

1 reference

12 December 2020

Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2

1 reference

12 December 2020

Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia

1 reference

12 December 2020

The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex

1 reference

12 December 2020

Defining the molecular basis of Arf and Hdm2 interactions

1 reference

12 December 2020

Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome

1 reference

12 December 2020

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

1 reference

12 December 2020

Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation

1 reference

12 December 2020

Cyclin G recruits PP2A to dephosphorylate Mdm2

1 reference

12 December 2020

Nucleophosmin regulates the stability and transcriptional activity of p53

1 reference

12 December 2020

Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation

1 reference

12 December 2020

Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

1 reference

12 December 2020

Hypophosphorylation of Mdm2 augments p53 stability

1 reference

12 December 2020

Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin

1 reference

12 December 2020

Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes

1 reference

12 December 2020

Intracellular ribozyme applications

1 reference

12 December 2020

Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2

1 reference

12 December 2020

Tumor suppression by Ink4a-Arf: progress and puzzles

1 reference

12 December 2020

Binding of an inhibitor of the p53/MDM2 interaction to MDM2.

1 reference

12 December 2020

TGFbeta-regulated transcriptional mechanisms in cancer

1 reference

12 December 2020

Mammalian Numb is a target protein of Mdm2, ubiquitin ligase

1 reference

12 December 2020

Regulation of MyoD Activity and Muscle Cell Differentiation by MDM2, pRb, and Sp1

1 reference

12 December 2020

Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells

1 reference

12 December 2020

The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation

1 reference

12 December 2020

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor

1 reference

12 December 2020

Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents

1 reference

12 December 2020

Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression

1 reference

12 December 2020

Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy

1 reference

12 December 2020

COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases

1 reference

12 December 2020

14-3-3σ Positively Regulates p53 and Suppresses Tumor Growth

1 reference

12 December 2020

Tumor promotion by Mdm2 splice variants unable to bind p53.

1 reference

12 December 2020

An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.

1 reference

12 December 2020

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

1 reference

12 December 2020

Regulation of p53 stability and function in HCT116 colon cancer cells

1 reference

12 December 2020

Merlin neutralizes the inhibitory effect of Mdm2 on p53.

1 reference

12 December 2020

Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions.

1 reference

12 December 2020

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

12 December 2020

MDM2, an introduction.

1 reference

12 December 2020

Posttranslational modification of MDM2

1 reference

12 December 2020

Chemosensitization and radiosensitization of human cancer by antisense anti-MDM2 oligonucleotides: in vitro and in vivo activities and mechanisms

1 reference

12 December 2020

MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides.

1 reference

12 December 2020

Phase I clinical trial of a human idiotypic p53 vaccine in patients with advanced malignancy

1 reference

12 December 2020

MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

1 reference

12 December 2020

Inhibition of p53 degradation by Mdm2 acetylation

1 reference

12 December 2020

Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation

1 reference

12 December 2020

How the nucleolar sequestration of p53 protein or its interplayers contributes to its (re)-activation

1 reference

12 December 2020

Inhibition of p53 function diminishes androgen receptor-mediated signaling in prostate cancer cell lines.

1 reference

12 December 2020

PTEN regulates Mdm2 expression through the P1 promoter

1 reference

12 December 2020

HAUSP is required for p53 destabilization

1 reference

12 December 2020

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

1 reference

12 December 2020

Yin Yang 1 is a negative regulator of p53.

1 reference

12 December 2020

Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells

1 reference

12 December 2020

Nucleophosmin, HDM2 and p53: players in UV damage incited nucleolar stress response.

1 reference

12 December 2020

Physiological and pathological consequences of the interactions of the p53 tumor suppressor with the glucocorticoid, androgen, and estrogen receptors.

1 reference

12 December 2020

Two distinct pathways of immuno-modulation improve potency of p53 immunization in rejecting established tumors.

1 reference

12 December 2020

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

1 reference

12 December 2020

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

1 reference

12 December 2020

Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs.

1 reference

12 December 2020

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

12 December 2020

The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth

1 reference

12 December 2020

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

1 reference

12 December 2020

Cloning and tissue-specific localization of cricket-type allatostatins from Gryllus bimaculatus.

1 reference

12 December 2020

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

1 reference

12 December 2020

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

1 reference

12 December 2020

Direct transcriptional regulation of MDM2 by Fli-1

1 reference

12 December 2020

Riboswitches--to kill or save the messenger.

1 reference

12 December 2020

Regulation of p53 and MDM2 activity by MTBP.

1 reference

12 December 2020

Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation

1 reference

12 December 2020

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

1 reference

12 December 2020

Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors

1 reference

12 December 2020

Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.

1 reference

12 December 2020

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

1 reference

12 December 2020

MDM2 is a central node in the p53 pathway: 12 years and counting

1 reference

12 December 2020

p53-independent activities of MDM2 and their relevance to cancer therapy

1 reference

12 December 2020

MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy

1 reference

12 December 2020

Chemosensitization by antisense oligonucleotides targeting MDM2.

1 reference

12 December 2020

Chalcones: an update on cytotoxic and chemoprotective properties

1 reference

12 December 2020

MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm.

1 reference

12 December 2020

Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.

1 reference

12 December 2020

Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.

1 reference

12 December 2020

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

1 reference

12 December 2020

The p53 pathway: positive and negative feedback loops

1 reference

12 December 2020

Regulation of the p73 protein stability and degradation

1 reference

12 December 2020

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase

1 reference

12 December 2020

Mdm2 and HIF-1alpha interaction in tumor cells during hypoxia.

1 reference

12 December 2020

Sumoylation induced by the Arf tumor suppressor: a p53-independent function

1 reference

12 December 2020

Functional implication of p73 protein stability in neuronal cell survival and death

1 reference

12 December 2020

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

1 reference

12 December 2020

Oncogenes as novel targets for cancer therapy (part I): growth factors and protein tyrosine kinases

1 reference

12 December 2020

p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53.

1 reference

12 December 2020

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

1 reference

12 December 2020

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

1 reference

12 December 2020

Oncogenes as novel targets for cancer therapy (part II): Intermediate signaling molecules

1 reference

12 December 2020

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

1 reference

12 December 2020

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation

1 reference

12 December 2020

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

12 December 2020

Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels

1 reference

12 December 2020

Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

1 reference

12 December 2020

Oncogenes as novel targets for cancer therapy (part III): transcription factors

1 reference

12 December 2020

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

1 reference

12 December 2020

Antisense approaches in drug discovery and development.

1 reference

12 December 2020

Selective pharmacologic activation of the p53-dependent pathway as a therapeutic strategy for hematologic malignancies

1 reference

12 December 2020

Oncogenes as novel targets for cancer therapy (part IV): regulators of the cell cycle and apoptosis

1 reference

12 December 2020

Differential regulation of cardiomyocyte survival and hypertrophy by MDM2, an E3 ubiquitin ligase

1 reference

12 December 2020

Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner

1 reference

12 December 2020

Novel MDM2 p53-independent functions identified through RNA silencing technologies

1 reference

12 December 2020

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

1 reference

12 December 2020

Yeast NSR1 protein that has structural similarity to mammalian nucleolin is involved in pre-rRNA processing

1 reference

12 December 2020

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

1 reference

12 December 2020

Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.

1 reference

12 December 2020

Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer

1 reference

12 December 2020

Radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2.

1 reference

12 December 2020

siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene

1 reference

12 December 2020

Strategies for therapeutic targeting of the p53 pathway in cancer.

1 reference

12 December 2020

Transcriptional regulation by p53: one protein, many possibilities

1 reference

12 December 2020

Gankyrin: a new oncoprotein and regulator of pRb and p53

1 reference

12 December 2020

The ARF tumour suppressor

1 reference

12 December 2020

The complexity of p53 stabilization and activation

1 reference

12 December 2020

Antisense-based cancer therapeutics: are we there yet?

1 reference

12 December 2020

A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome

1 reference

12 December 2020

Molecular control of cell cycle progression in the pancreatic beta-cell

1 reference

12 December 2020

The proteasome activator PA28 functions in collaboration with Hsp90 in vivo

1 reference

12 December 2020

p53 as a target for anti-cancer drug development.

1 reference

12 December 2020

Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins.

1 reference

12 December 2020

Cellular functions of TIP60

1 reference

12 December 2020

MDM2 SNP309 Accelerates Tumor Formation in a Gender-Specific and Hormone-Dependent Manner

1 reference

12 December 2020

Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization.

1 reference

12 December 2020

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

1 reference

12 December 2020

Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism

1 reference

12 December 2020

Association of breast cancer outcome with status of p53 and MDM2 SNP309

1 reference

12 December 2020

Critical role for Daxx in regulating Mdm2

1 reference

12 December 2020

DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer

1 reference

12 December 2020

Balancing Mdm2 - a Daxx-HAUSP matter

1 reference

12 December 2020

Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

1 reference

12 December 2020

B23 and ARF: friends or foes?

1 reference

12 December 2020

Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function

1 reference

12 December 2020

p53 modulation of the DNA damage response

1 reference

12 December 2020

Gankyrin, the 26 S proteasome, the cell cycle and cancer

1 reference

12 December 2020

KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction

1 reference

12 December 2020

Human MDM2 isoforms translated differentially on constitutive versus p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops

1 reference

12 December 2020

P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity

1 reference

12 December 2020

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

1 reference

12 December 2020

Mdm2 targets the p53 transcription cofactor JMY for degradation

1 reference

12 December 2020

Antisense oligonucleotides: target validation and development of systemically delivered therapeutic nanoparticles

1 reference

12 December 2020

Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk.

1 reference

12 December 2020

Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF

1 reference

12 December 2020

Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.

1 reference

12 December 2020

MDMX: from bench to bedside

1 reference

12 December 2020

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

1 reference

12 December 2020

Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2

1 reference

12 December 2020

Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP).

1 reference

12 December 2020

Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression

1 reference

12 December 2020

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

1 reference

12 December 2020

A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans

1 reference

12 December 2020

Distinct roles of MDMX in the regulation of p53 response to ribosomal stress

1 reference

12 December 2020

Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway

1 reference

12 December 2020

Targeting different signaling pathways with antisense oligonucleotides combination for cancer therapy.

1 reference

12 December 2020

MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation

1 reference

12 December 2020

Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest

1 reference

12 December 2020

p53 in health and disease

1 reference

12 December 2020

In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage

1 reference

12 December 2020

MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal

1 reference

12 December 2020

The RING finger domain of MDM2 is essential for MDM2-mediated TGF-beta resistance

1 reference

12 December 2020

PACT is a negative regulator of p53 and essential for cell growth and embryonic development

1 reference

12 December 2020

Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway

1 reference

12 December 2020

Inhibition of p53-murine double minute 2 interaction by nutlin-3A stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma

1 reference

12 December 2020

Differential regulation of estrogen receptor alpha turnover and transactivation by Mdm2 and stress-inducing agents

1 reference

12 December 2020

Roles for negative cell regulator 14-3-3σ in control of MDM2 activities

1 reference

12 December 2020

Solid-phase synthesis of chlorofusin analogues

1 reference

12 December 2020

p21 (CDKN1A) is a negative regulator of p53 stability.

1 reference

12 December 2020

HAUSP-regulated switch from auto- to p53 ubiquitination by Mdm2 (in silico discovery).

1 reference

12 December 2020

Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome

1 reference

12 December 2020

How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

1 reference

12 December 2020

A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop

1 reference

12 December 2020

MDM2 chaperones the p53 tumor suppressor

1 reference

12 December 2020

Potent p53-independent tumor suppressor activity of ARF in melanoma-genesis

1 reference

12 December 2020

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX

1 reference

12 December 2020

Roles for CSN5 in control of p53/MDM2 activities.

1 reference

12 December 2020

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

1 reference

12 December 2020

Tiny actors, great roles: microRNAs in p53's service.

1 reference

12 December 2020

Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity

1 reference

12 December 2020

p73 expression modulates p63 and Mdm2 protein presence in complex with p53 family-specific DNA target sequence in squamous cell carcinogenesis

1 reference

12 December 2020

Targeting MDM2 and MDMX in retinoblastoma

1 reference

12 December 2020

Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma

1 reference

12 December 2020

NUMB controls p53 tumour suppressor activity

1 reference

12 December 2020

Antisense MDM2 enhances the response of androgen insensitive human prostate cancer cells to androgen deprivation in vitro and in vivo

1 reference

12 December 2020

Regulation of Angiogenic Factors by HDM2 in Renal Cell Carcinoma

1 reference

12 December 2020

Diagnosing and exploiting cancer's addiction to blocks in apoptosis

1 reference

12 December 2020

Imatinib mesylate in chronic myeloid leukemia

1 reference

12 December 2020

1 reference

12 December 2020

TAp73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation

1 reference

12 December 2020

PML enhances the regulation of p53 by CK1 in response to DNA damage

1 reference

12 December 2020

20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action

1 reference

12 December 2020

Specific inhibition of Mdm2-mediated neddylation by Tip60

1 reference

12 December 2020

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen

1 reference

12 December 2020

Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11

1 reference

12 December 2020

Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation

1 reference

12 December 2020

Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides

1 reference

12 December 2020

The Wip1 phosphatase and Mdm2: cracking the "Wip" on p53 stability

1 reference

12 December 2020

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies

1 reference

12 December 2020

Participation of p53 protein in the cellular response to DNA damage

1 reference

12 December 2020

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line

1 reference

12 December 2020

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

12 December 2020

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

12 December 2020

MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis

1 reference

12 December 2020

Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing

1 reference

12 December 2020

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

1 reference

12 December 2020

The p53-mdm-2 autoregulatory feedback loop

1 reference

12 December 2020

Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells

1 reference

12 December 2020

MDMX: a novel p53-binding protein with some functional properties of MDM2

1 reference

12 December 2020

p53, WAF1/CIP1 and mdm2 expression in skin lesions associated with human papillomavirus and human immunodeficiency virus

1 reference

12 December 2020

Regulation of p53 stability by Mdm2

1 reference

12 December 2020

Molecular characterization of the hdm2-p53 interaction

1 reference

12 December 2020

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

12 December 2020

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

12 December 2020

The Mdm2 oncoprotein interacts with the cell fate regulator Numb

1 reference

12 December 2020

Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function

1 reference

12 December 2020

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

1 reference

12 December 2020

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

12 December 2020

Mdm2 association with p53 targets its ubiquitination

1 reference

12 December 2020

p53-independent role of MDM2 in TGF-beta1 resistance

1 reference

12 December 2020

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

12 December 2020

10.2174/187152009789124628

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19538162%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference