(Q89587304)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32030687%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

review article

1 reference

title

Rho-ROCK Signaling in Normal Physiology and as a Key Player in Shaping the Tumor Microenvironment (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32030687%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

author name string

Sean Porazinski

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32030687%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Ashleigh Parkin

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32030687%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Marina Pajic

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32030687%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

publication date

1 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32030687%20AND%20SRC:MED&resulttype=core&format=json

Advances in Experimental Medicine and Biology

6 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32030687%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

volume

1223

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32030687%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

page(s)

99-127

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32030687%20AND%20SRC:MED&resulttype=core&format=json

Rho-kinase: regulation, (dys)function, and inhibition

6 April 2020

cites work

1 reference

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Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities

31 March 2020

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ROCK inhibition in models of neurodegeneration and its potential for clinical translation.

31 March 2020

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Pathophysiological effects of RhoA and Rho-associated kinase on cardiovascular system

31 March 2020

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The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.

31 March 2020

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Vitamin A-coupled liposomal Rho-kinase inhibitor ameliorates liver fibrosis without systemic adverse effects

31 March 2020

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31 March 2020

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Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma

31 March 2020

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The ROCK signaling and breast cancer metastasis

31 March 2020

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Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarinoma Invasion and Tumor Growth.

31 March 2020

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Rho kinase inhibitors: a patent review (2014 - 2016).

31 March 2020

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ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

31 March 2020

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Regulation of ROCK activity in cancer

31 March 2020

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Regulation of ROCKII membrane localization through its C-terminus

31 March 2020

1 reference

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Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation

31 March 2020

1 reference

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Cycling around cell-cell adhesion with Rho GTPase regulators

31 March 2020

1 reference

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Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

31 March 2020

1 reference

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Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity

31 March 2020

1 reference

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Rho-family GTPases: it's not only Rac and Rho (and I like it).

31 March 2020

1 reference

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Regulation of small GTPases by GEFs, GAPs, and GDIs

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Regulation of myosin light chain phosphorylation by RhoB in neuronal cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RhoE binds to ROCK I and inhibits downstream signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The Rho kinases I and II regulate different aspects of myosin II activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Functions of Rho family of small GTPases and Rho-associated coiled-coil kinases in bone cells during differentiation and mineralization.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho GTPases: biochemistry and biology

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho-associated coiled-coil kinase (ROCK) signaling and disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Microtubule remodelling is required for the front-rear polarity switch during contact inhibition of locomotion

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Adiponectin stimulates Rho-mediated actin cytoskeleton remodeling and glucose uptake via APPL1 in primary cardiomyocytes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Neuroprotection mediated by changes in the endothelial actin cytoskeleton.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RhoA, RhoB and RhoC have different roles in cancer cell migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin intermediate filament network

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

p63RhoGEF: a new switch for G(q)-mediated activation of smooth muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Integrins, growth factors, and the osteoclast cytoskeleton

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho family GTPases and their regulators in lymphocytes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Crosstalk between small GTPases and polarity proteins in cell polarization.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Always look on the bright site of Rho: structural implications for a conserved intermolecular interface

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

p190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK inhibition prevents early mouse embryo development.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Creation of trophectoderm, the first epithelium, in mouse preimplantation development

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK and RHO Playlist for Preimplantation Development: Streaming to HIPPO Pathway and Apicobasal Polarity in the First Cell Differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A ROCK inhibitor permits survival of dissociated human embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Molecular specification of germ layers in vertebrate embryos

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Neural crest specification by inhibition of the ROCK/Myosin II pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymal stem cells via CD44 mediated PDGFR signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Distinct GATA6- and laminin-dependent mechanisms regulate endodermal and ectodermal embryonic stem cell fates

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho GTPases in endoderm development and differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell-derived Flk1(+) mesodermal precursor cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho GTPase signaling complexes in cell migration and invasion

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The planar cell polarity pathway and parietal endoderm cell migration.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho kinase activity controls directional cell movements during primitive streak formation in the rabbit embryo

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho-kinase and myosin II affect dynamic neural crest cell behaviors during epithelial to mesenchymal transition in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Molecular analysis of neural crest migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho GTPases in mammalian spinal neural tube closure.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

YAP is essential for tissue tension to ensure vertebrate 3D body shape

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Role of YAP/TAZ in mechanotransduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Acute compressive stress activates RHO/ROCK-mediated cellular processes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Self-organizing optic-cup morphogenesis in three-dimensional culture

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho signaling research: history, current status and future directions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Discovery of long-range inhibitory signaling to ensure single axon formation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and Rho

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Surface topography during neural stem cell differentiation regulates cell migration and cell morphology.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RHOA-ROCK signalling is necessary for lateralization and differentiation of the developing sinoatrial node.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho-Associated Kinases and Non-muscle Myosin IIs Inhibit the Differentiation of Human iPSCs to Pancreatic Endoderm

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A high-content small molecule screen identifies novel inducers of definitive endoderm

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCKII inhibition promotes the maturation of human pancreatic beta-like cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A tense situation: forcing tumour progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

An overview of epithelio-mesenchymal transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Inhibition of ROCK activity regulates the balance of Th1, Th17 and Treg cells in myasthenia gravis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCKing cytokine secretion balance in human T cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Targeted disruption of ROCK1 causes insulin resistance in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Dual roles for RHOA/RHO-kinase in the regulated trafficking of a voltage-sensitive potassium channel

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Y-27632, a Rho-Associated Protein Kinase Inhibitor, Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Regulation of neuronal high-voltage activated Ca(V)2 Ca(2+) channels by the small GTPase RhoA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Metabotropic regulation of RhoA/Rho-associated kinase by L-type Ca2+ channels

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Fasudil, a Rho-Associated Coiled Coil-Forming Protein Kinase Inhibitor, Recovers Methylmercury-Induced Axonal Degeneration by Changing Microglial Phenotype in Rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho Kinases and Cardiac Remodeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Disruption of embryonic ROCK signaling reproduces the sarcomeric phenotype of hypertrophic cardiomyopathy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Elevated BMP and Mechanical Signaling Through YAP1/RhoA Poises FOP Mesenchymal Progenitors for Osteogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A comprehensive survey of Ras mutations in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Mutational landscape and significance across 12 major cancer types

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Whole genomes redefine the mutational landscape of pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A landscape of driver mutations in melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Transforming mutations of RAC guanosine triphosphatases in human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho-associated kinase is a therapeutic target in neuroblastoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Novel Insights into the Roles of Rho Kinase in Cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The actin cytoskeleton in cancer cell motility

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho GTPases: masters of cell migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RhoA and RhoC have distinct roles in migration and invasion by acting through different targets

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RhoB regulates cell migration through altered focal adhesion dynamics

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Understanding the tumor immune microenvironment (TIME) for effective therapy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A peek into cancer-associated fibroblasts: origins, functions and translational impact.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Mechano-reciprocity is maintained between physiological boundaries by tuning signal flux through the Rho-associated protein kinase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK inhibition with Fasudil induces beta-catenin nuclear translocation and inhibits cell migration of MDA-MB 231 human breast cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Myofibroblasts and mechano-regulation of connective tissue remodelling

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

LIF mediates proinvasive activation of stromal fibroblasts in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Oral cancer-associated fibroblasts predict poor survival: Systematic review and meta-analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Comparisons of cancer-associated fibroblasts in the intratumoral stroma and invasive front in colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

31 March 2020

Fibroblasts in cancer

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Fibroblasts in omentum activated by tumor cells promote ovarian cancer growth, adhesion and invasiveness.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Cancer-associated fibroblasts from hepatocellular carcinoma promote malignant cell proliferation by HGF secretion

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Direct Interaction of Focal Adhesion Kinase with p190RhoGEF

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Mechanotransduction pathways promoting tumor progression are activated in invasive human squamous cell carcinoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho–ROCK signaling regulates tumor-microenvironment interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Multiple roles for RhoA during T cell transendothelial migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Role of Rho kinase isoforms in murine allergic airway responses.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Tumour-associated macrophages as treatment targets in oncology.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Matrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like Structures

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The pancreas cancer microenvironment

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Isolation of quiescent human pancreatic stellate cells: a promising in vitro tool for studies of human pancreatic stellate cell biology

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho kinase inhibitors block activation of pancreatic stellate cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Early requirement of Rac1 in a mouse model of pancreatic cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

EphA2 Drives the Segregation of Ras-Transformed Epithelial Cells from Normal Neighbors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Characterization of the interface between normal and transformed epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Pathology: cancer cells compress intratumour vessels.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The tension mounts: mechanics meets morphogenesis and malignancy

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Tensional homeostasis and the malignant phenotype

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

VHL gene mutations in renal cell carcinoma: role as a biomarker of disease outcome and drug efficacy

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

HIF-1α mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

RhoA is associated with invasion and lymph node metastasis in upper urinary tract cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

ROCK Inhibition Induces Terminal Adipocyte Differentiation and Suppresses Tumorigenesis in Chemoresistant Osteosarcoma Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Developments in preclinical cancer imaging: innovating the discovery of therapeutics.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Collective cell durotaxis emerges from long-range intercellular force transmission

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

Rho kinase inhibitors block melanoma cell migration and inhibit metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A study of paclitaxel, carboplatin, and bortezomib in the treatment of metastatic malignant melanoma: a phase 2 consortium study

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

A phase II study of bortezomib in the treatment of metastatic malignant melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-35582-1_6

10.1007/978-3-030-35582-1_6

31 March 2020

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32030687%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

1 reference