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Cellular mechanisms of γ-secretase substrate selection, processing and toxicity
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title
Cellular mechanisms of γ-secretase substrate selection, processing and toxicity
(English)
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stated in
PubMed
author name string
Gael Barthet
series ordinal
1
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Crossref
Anastasios Georgakopoulos
series ordinal
2
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stated in
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Nikolaos K. Robakis
series ordinal
3
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Crossref
language of work or name
English
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stated in
PubMed
publication date
August 2012
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stated in
PubMed
published in
Progress in Neurobiology
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stated in
PubMed
volume
98
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PubMed
issue
2
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PubMed
page(s)
166-75
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PubMed
cites work
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease
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PubMed Central
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Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease
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PubMed Central
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21 March 2017
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
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21 March 2017
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
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PubMed Central
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21 March 2017
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
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stated in
PubMed Central
reference URL
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21 March 2017
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
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21 March 2017
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
1 reference
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PubMed Central
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21 March 2017
X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
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21 March 2017
Presenilin 1 interaction in the brain with a novel member of the Armadillo family
1 reference
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PubMed Central
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21 March 2017
Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
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21 March 2017
The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
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21 March 2017
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations
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PubMed Central
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21 March 2017
gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
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PubMed Central
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21 March 2017
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
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PubMed Central
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21 March 2017
Identification of distinct gamma-secretase complexes with different APH-1 variants
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PubMed Central
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21 March 2017
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex
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PubMed Central
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21 March 2017
Altered Abeta formation and long-term potentiation in a calsenilin knock-out
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21 March 2017
Presenilin-dependent receptor processing is required for axon guidance
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21 March 2017
Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates
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21 March 2017
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin
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21 March 2017
Amyloid precursor protein trafficking, processing, and function
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7 April 2017
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
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7 April 2017
Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1
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28 September 2017
Novel γ-secretase enzyme modulators directly target presenilin protein
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28 September 2017
Synaptic autoregulation by metalloproteases and γ-secretase
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28 September 2017
Calsenilin regulates presenilin 1/γ-secretase-mediated N-cadherin ε-cleavage and β-catenin signaling
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28 September 2017
Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates
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28 September 2017
Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1
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28 September 2017
EphB controls NMDA receptor function and synaptic targeting in a subunit-specific manner
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28 September 2017
AAA+ proteases: ATP-fueled machines of protein destruction
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28 September 2017
Targets for AD treatment: conflicting messages from γ-secretase inhibitors
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28 September 2017
Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release
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28 September 2017
Activation and intrinsic gamma-secretase activity of presenilin 1.
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28 September 2017
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis
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28 September 2017
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease
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28 September 2017
Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives
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28 September 2017
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.
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28 September 2017
Glu-333 of nicastrin directly participates in gamma-secretase activity
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28 September 2017
TMP21 transmembrane domain regulates gamma-secretase cleavage
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28 September 2017
Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptors.
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28 September 2017
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes
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28 September 2017
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease
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28 September 2017
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons
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28 September 2017
Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity
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28 September 2017
p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide
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28 September 2017
Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
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28 September 2017
p120-catenin is a key component of the cadherin-gamma-secretase supercomplex
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28 September 2017
Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity
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PubMed Central
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28 September 2017
Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes
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28 September 2017
The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism
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28 September 2017
The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid
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28 September 2017
The X11/Mint family of adaptor proteins.
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28 September 2017
Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability
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PubMed Central
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28 September 2017
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site
1 reference
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PubMed Central
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28 September 2017
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling
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28 September 2017
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.
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28 September 2017
Presenilin-interacting proteins
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28 September 2017
An Alzheimer's disease hypothesis based on transcriptional dysregulation
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28 September 2017
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
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PubMed Central
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28 September 2017
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate
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28 September 2017
Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors
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28 September 2017
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
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28 September 2017
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor
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28 September 2017
Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts
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PubMed Central
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28 September 2017
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling
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28 September 2017
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
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28 September 2017
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
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28 September 2017
Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1
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31 May 2018
Nicastrin binds to membrane-tethered Notch
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31 May 2018
Alzheimer's disease: a re-examination of the amyloid hypothesis
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31 May 2018
A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
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31 May 2018
Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells
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31 May 2018
The Alzheimer's Amyloid Precursor Is Cleaved Intracellularly in the Trans‐Golgi Network or in a Post‐Golgi Compartment a
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31 May 2018
Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
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28 November 2018
What can be inferred from the interruption of the semagacestat trial for treatment of Alzheimer's disease?
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28 November 2018
A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Nicastrin functions as a gamma-secretase-substrate receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Neurobiology: double trouble for neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404154
retrieved
28 November 2018
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22622135
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.PNEUROBIO.2012.05.006
0 references
PMCID
3404154
1 reference
stated in
PubMed
PubMed ID
22622135
1 reference
stated in
PubMed
ResearchGate publication ID
225058184
0 references
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