(Q35676850)

English

Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.

scientific article published on 18 September 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 August 2017

Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1. (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Christian Haass

3

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Christian Haass

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author name string

Harald Steiner

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Edith Winkler

2

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Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

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publication date

18 September 2008

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Europe PubMed Central

PubMed publication ID

9 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

9 August 2017

283

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Europe PubMed Central

PubMed publication ID

9 August 2017

50

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

34677-34686

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Active gamma-secretase complexes contain only one of each component

1 reference

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

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12 July 2018

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

1 reference

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12 July 2018

Notch signalling: a simple pathway becomes complex

1 reference

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12 July 2018

Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes

1 reference

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12 July 2018

Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking

1 reference

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12 July 2018

Dimeric organization of the yeast oligosaccharyl transferase complex

1 reference

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12 July 2018

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

1 reference

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12 July 2018

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.

1 reference

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12 July 2018

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

1 reference

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12 July 2018

Uncovering gamma-secretase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Gamma-secretase complex assembly within the early secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Identification of distinct gamma-secretase complexes with different APH-1 variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

The gamma-secretase complex: machinery for intramembrane proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259863

12 July 2018

Gamma-secretase: proteasome of the membrane?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709067200

21 January 2018

Identifiers

10.1074/JBC.M709067200

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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