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Population genetic tools for dissecting innate immunity in humans
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scholarly article
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stated in
PubMed
title
Population genetic tools for dissecting innate immunity in humans
(English)
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main subject
population genetics
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author
Lluís Quintana-Murci
object named as
Lluís Quintana-Murci
series ordinal
1
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Andrew G. Clark
object named as
Andrew G. Clark
series ordinal
2
1 reference
stated in
ORCID Public Data File 2021
language of work or name
English
1 reference
stated in
PubMed
publication date
April 2013
1 reference
stated in
PubMed
published in
Nature Reviews Immunology
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stated in
PubMed
volume
13
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stated in
PubMed
page(s)
280-93
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stated in
PubMed
issue
4
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stated in
PubMed
cites work
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The inflammasomes
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Patterns of positive selection in six Mammalian genomes
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The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates
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Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes
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Spread of an inactive form of caspase-12 in humans is due to recent positive selection
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A map of recent positive selection in the human genome
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Complex signatures of natural selection at the Duffy blood group locus
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Pyogenic bacterial infections in humans with IRAK-4 deficiency
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Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
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Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
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Herpes simplex virus encephalitis in human UNC-93B deficiency
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Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3
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Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans
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Natural selection on genes that underlie human disease susceptibility
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Directional and balancing selection in human beta-defensins
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Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9
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7 April 2017
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7 April 2017
The gut microbiota shapes intestinal immune responses during health and disease
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7 April 2017
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
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7 April 2017
Inflammasomes in health and disease
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7 April 2017
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
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7 April 2017
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
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7 April 2017
Recognition of microorganisms and activation of the immune response
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7 April 2017
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7 April 2017
The host defense of Drosophila melanogaster
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7 April 2017
Positive natural selection in the human lineage
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7 April 2017
Natural selection on protein-coding genes in the human genome
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7 April 2017
Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios
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7 April 2017
Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection
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7 April 2017
Gene conversion and evolution of gene families: an overview
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28 September 2017
Linking disease associations with regulatory information in the human genome
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28 September 2017
Personal and population genomics of human regulatory variation
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28 September 2017
The evolutionary landscape of cytosolic microbial sensors in humans
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28 September 2017
Mannan-binding lectin deficiency - Good news, bad news, doesn't matter?
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28 September 2017
Human genetic susceptibility to infectious disease
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28 September 2017
How do plants achieve immunity? Defence without specialized immune cells
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28 September 2017
Signaling by myeloid C-type lectin receptors in immunity and homeostasis
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28 September 2017
Evolutionary genetic dissection of human interferons
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28 September 2017
Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution
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28 September 2017
Genetic adaptation of the antibacterial human innate immunity network
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28 September 2017
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
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28 September 2017
Evolutionary genetics evidence of an essential, nonredundant role of the IFN-γ pathway in protective immunity
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28 September 2017
Human genetic susceptibility to intracellular pathogens
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28 September 2017
Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics
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28 September 2017
Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity?
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28 September 2017
Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma
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28 September 2017
Carriers of rare missense variants in IFIH1 are protected from psoriasis
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28 September 2017
Comparative genomics and evolution of the alpha-defensin multigene family in primates
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28 September 2017
A new vision of immunity: homeostasis of the superorganism
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28 September 2017
Adaptation and constraint at Toll-like receptors in primates
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28 September 2017
Human and non-human primate genomes share hotspots of positive selection
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28 September 2017
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28 September 2017
From evolutionary genetics to human immunology: how selection shapes host defence genes
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28 September 2017
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28 September 2017
Targets of balancing selection in the human genome
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28 September 2017
Evolutionary processes acting on candidate cis-regulatory regions in humans inferred from patterns of polymorphism and divergence
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28 September 2017
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock
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28 September 2017
Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions
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28 September 2017
Constructing genomic maps of positive selection in humans: where do we go from here?
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28 September 2017
Signatures of natural selection are not uniform across genes of innate immune system, but purifying selection is the dominant signature
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28 September 2017
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28 September 2017
A history of recurrent positive selection at the toll-like receptor 5 in primates
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28 September 2017
Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense
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28 September 2017
Allelic recombination between distinct genomic locations generates copy number diversity in human beta-defensins.
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28 September 2017
Gene expression levels are a target of recent natural selection in the human genome
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28 September 2017
The signature of long-standing balancing selection at the human defensin beta-1 promoter.
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28 September 2017
Patterns of evolution and host gene mimicry in influenza and other RNA viruses
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28 September 2017
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28 September 2017
Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction
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28 September 2017
Proportionally more deleterious genetic variation in European than in African populations.
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28 September 2017
Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease
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28 September 2017
Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity
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28 September 2017
Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases
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28 September 2017
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
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28 September 2017
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28 September 2017
Up to new tricks - a review of cross-species transmission of influenza A viruses.
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28 September 2017
A common human TLR1 polymorphism regulates the innate immune response to lipopeptides
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28 September 2017
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28 September 2017
Most rare missense alleles are deleterious in humans: implications for complex disease and association studies
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28 September 2017
Human genetics of infectious diseases: a unified theory
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28 September 2017
Nucleic acid-sensing TLRs as modifiers of autoimmunity
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28 September 2017
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28 September 2017
Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis
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28 September 2017
Population genetics models of common diseases
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28 September 2017
Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features
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28 September 2017
Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes.
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28 September 2017
Defensins in innate antiviral immunity
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28 September 2017
Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
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28 September 2017
Balancing selection and its effects on sequences in nearby genome regions
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28 September 2017
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large
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28 September 2017
The evolution of adaptive immune systems
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28 September 2017
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28 September 2017
Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans
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28 September 2017
An interferon-gamma-related cytokine storm in SARS patients
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28 September 2017
Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?
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28 September 2017
A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease
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28 September 2017
Impact of mannose-binding lectin on susceptibility to infectious diseases.
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28 September 2017
Natural selection drives Drosophila immune system evolution.
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28 September 2017
Collections and ficolins: humoral lectins of the innate immune defense
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28 September 2017
Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis
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28 September 2017
Mannan-binding lectin enhances susceptibility to visceral leishmaniasis
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28 September 2017
The evolution and genetics of innate immunity
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28 September 2017
Adaptive evolution of relish, a Drosophila NF-kappaB/IkappaB protein
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28 September 2017
Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes
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28 September 2017
The evolution of antifungal peptides in Drosophila
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31 May 2018
The selective footprints of viral pressures at the human RIG-I-like receptor family.
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31 May 2018
Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation
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28 November 2018
Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes
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28 November 2018
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.
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28 November 2018
A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes
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28 November 2018
Natural selection in the TLR-related genes in the course of primate evolution
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28 November 2018
Balancing selection is the main force shaping the evolution of innate immunity genes
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28 November 2018
Dynamic evolution of the innate immune system in Drosophila.
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28 November 2018
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28 November 2018
Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles
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28 November 2018
Asthma and atopy are associated with DEFB1 polymorphisms in Chinese children.
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28 November 2018
Searching for signals of evolutionary selection in 168 genes related to immune function.
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28 November 2018
Pathogen-Driven Selection and Worldwide HLA Class I Diversity
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28 November 2018
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28 November 2018
Mannose-binding protein B allele confers protection against tuberculous meningitis
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28 November 2018
NLR functions beyond pathogen recognition
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31 March 2020
Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection
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31 March 2020
Genomic variations within DEFB1 are associated with the susceptibility to and the fatal outcome of severe sepsis in Chinese Han population
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31 March 2020
Association between deficiency of mannose-binding lectin and severe infections after chemotherapy
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31 March 2020
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy
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Identifiers
DOI
10.1038/NRI3421
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2652845
OpenCitations bibliographic resource ID
2652845
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2652845
PMCID
4015519
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2652845
PubMed ID
23470320
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2652845
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