(Q27667312)

English

Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics

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Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics (English)

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1 reference

based on heuristic

inferred from title

Benjamin Cravatt

9

object named as

Benjamin F Cravatt

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author name string

Cyrine Ezzili

1

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Mauro Mileni

2

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Nicholas McGlinchey

3

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Jonathan Z Long

4

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Steven G Kinsey

5

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Dustin G Hochstatter

6

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Raymond C Stevens

7

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Aron H Lichtman

8

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Edward J Bilsky

10

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Dale L Boger

11

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language of work or name

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publication date

28 April 2011

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Journal of Medicinal Chemistry

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54

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8

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2805-22

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Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase

1 reference

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1 reference

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Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

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Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism

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Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

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N-acylated glycerophospholipids and their derivatives

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Elucidation of fatty acid amide hydrolase inhibition by potent alpha-ketoheterocycle derivatives from Monte Carlo simulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Rapid boundary element solvation electrostatics calculations in folding simulations: successful folding of a 23-residue peptide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Development of orally active nonpeptidic inhibitors of human neutrophil elastase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085948

27 November 2018

Fatty acid amide hydrolase substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21428410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/21428410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring

1 reference

https://pubmed.ncbi.nlm.nih.gov/21428410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21428410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21428410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel inhibitors of fatty acid amide hydrolase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21428410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21428410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel Inhibitors of Brain, Neuronal, and Basophilic Anandamide Amidohydrolase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21428410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of arachidonoyl ethanolamide hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21428410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM101597X

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