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Regulation of distinct pools of amyloid β-protein by multiple cellular proteases
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scholarly article
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PubMed
title
Regulation of distinct pools of amyloid β-protein by multiple cellular proteases
(English)
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stated in
PubMed
author name string
Malcolm A Leissring
series ordinal
1
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stated in
Crossref
Anthony J Turner
series ordinal
2
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stated in
Crossref
language of work or name
English
0 references
publication date
13 August 2013
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stated in
PubMed
published in
Alzheimers Research & Therapy
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Crossref
volume
5
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PubMed
issue
4
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PubMed
page(s)
37
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PubMed
cites work
Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
20 March 2017
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
20 March 2017
Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
7 April 2017
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
20 March 2017
Amyloid precursor protein trafficking, processing, and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
7 April 2017
Intracellular amyloid-beta in Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
7 April 2017
Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Proteolytic degradation of amyloid β-protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
New insights in the amyloid-Beta interaction with mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
The secretases: enzymes with therapeutic potential in Alzheimer disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
The AbetaCs of Abeta-cleaving proteases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Proteolytic degradation of the amyloid beta-protein: the forgotten side of Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Cytosolic amyloid-beta peptide 42 escaping from degradation induces cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
beta-Secretase, APP and Abeta in Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Deciphering the molecular basis of memory failure in Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Intraneuronal Abeta42 accumulation in human brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Translating cell biology into therapeutic advances in Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
29 September 2017
Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
2 June 2018
Degradation of Alzheimer's beta-amyloid protein by human cathepsin D.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
2 June 2018
The origins of Alzheimer disease: a is for amyloid.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1186%2FALZRT194
retrieved
21 January 2018
Endoplasmic reticulum-localized amyloid beta-peptide is degraded in the cytosol by two distinct degradation pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1186%2FALZRT194
retrieved
21 January 2018
The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1186%2FALZRT194
retrieved
21 January 2018
Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1186%2FALZRT194
retrieved
21 January 2018
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1186%2FALZRT194
retrieved
21 January 2018
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1186%2FALZRT194
retrieved
21 January 2018
Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978621
retrieved
27 November 2018
Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23953275
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23953275
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1186/ALZRT194
0 references
Dimensions Publication ID
1028839251
1 reference
stated in
SciGraph
retrieved
9 September 2019
reference URL
https://scigraph.springernature.com/pub.10.1186/alzrt194
PMC publication ID
3978621
1 reference
stated in
PubMed
PubMed publication ID
23953275
1 reference
stated in
PubMed
ResearchGate publication ID
255973734
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