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Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells
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scholarly article
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stated in
PubMed
review article
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stated in
Europe PubMed Central
title
Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells
(English)
1 reference
stated in
PubMed
main subject
neoplastic stem cells
1 reference
based on heuristic
inferred from title
author name string
V. Justilien
series ordinal
1
1 reference
stated in
Crossref
A. P. Fields
series ordinal
2
1 reference
stated in
Crossref
language of work or name
English
1 reference
stated in
PubMed
publication date
1 February 2015
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stated in
PubMed
published in
Clinical Cancer Research
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stated in
PubMed
volume
21
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stated in
PubMed
issue
3
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stated in
PubMed
page(s)
505-13
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stated in
PubMed
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The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma
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Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model
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Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site
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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
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A small molecule that binds Hedgehog and blocks its signaling in human cells
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Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
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Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
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Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
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Patched1 regulates hedgehog signaling at the primary cilium
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CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance
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29 September 2017
Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer
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Emerging landscape of oncogenic signatures across human cancers
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Hedgehog targeting by cyclopamine suppresses head and neck squamous cell carcinoma and enhances chemotherapeutic effects
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Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling
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Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance
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PubMed Central
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29 September 2017
Smoothened antagonists reverse taxane resistance in ovarian cancer
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29 September 2017
Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth
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29 September 2017
Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells
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29 September 2017
Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier
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29 September 2017
In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines.
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A crucial requirement for Hedgehog signaling in small cell lung cancer
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29 September 2017
Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer
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29 September 2017
Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma
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29 September 2017
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29 September 2017
Hedgehog signaling and pancreatic tumor development
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29 September 2017
Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.
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29 September 2017
Hedgehog signaling drives cellular survival in human colon carcinoma cells
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29 September 2017
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance
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29 September 2017
Hedgehog signaling maintains chemoresistance in myeloid leukemic cells.
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29 September 2017
Targeting Hedgehog--a cancer stem cell pathway
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29 September 2017
The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment
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29 September 2017
Smoothened as a new therapeutic target for human osteosarcoma
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29 September 2017
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
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29 September 2017
The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth
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PubMed Central
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29 September 2017
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
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29 September 2017
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
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29 September 2017
Paracrine Hedgehog signaling in cancer
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29 September 2017
A critical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cells
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29 September 2017
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
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29 September 2017
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
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29 September 2017
Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer
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29 September 2017
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
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29 September 2017
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
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29 September 2017
Role of hedgehog signaling in ovarian cancer
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29 September 2017
Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation
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29 September 2017
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.
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29 September 2017
A paracrine requirement for hedgehog signalling in cancer
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29 September 2017
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer
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29 September 2017
Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas
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29 September 2017
Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum
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29 September 2017
Essential role of stromally induced hedgehog signaling in B-cell malignancies
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PubMed Central
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29 September 2017
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
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29 September 2017
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.
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29 September 2017
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
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29 September 2017
Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport
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29 September 2017
Overexpression of hedgehog signaling molecules and its involvement in the proliferation of endometrial carcinoma cells
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retrieved
29 September 2017
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
29 September 2017
Defining the mode of tumour growth by clonal analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
2 June 2018
Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
2 June 2018
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
2 June 2018
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
2 June 2018
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
2 June 2018
Amplification of the gli gene in childhood sarcomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
28 July 2018
Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
27 November 2018
Hedgehog pathway regulators influence cervical cancer cell proliferation, survival and migration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
27 November 2018
Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
27 November 2018
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
27 November 2018
Hedgehog signaling is activated in subsets of esophageal cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
27 November 2018
Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
27 November 2018
GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316382
retrieved
27 November 2018
Congenital Deformities in Lambs, Calves, and Goats Resulting from Maternal Ingestion ofVeratrum californicum; Hare Lip, Cleft Palate, Ataxia, and Hypoplasia of Metacarpal and Metatarsal Bones
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25646180
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25646180
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1158/1078-0432.CCR-14-0507
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1042323
OpenCitations bibliographic resource ID
1042323
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1042323
PMCID
4316382
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1042323
PubMed ID
25646180
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1042323
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