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Beyond indigestion: emerging roles for lysosome-based signaling in human disease
scientific article published in August 2015
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review article
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title
Beyond indigestion: emerging roles for lysosome-based signaling in human disease
(English)
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PubMed
main subject
indigestion
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based on heuristic
inferred from title
author name string
Shawn M Ferguson
series ordinal
1
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language of work or name
English
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PubMed
publication date
August 2015
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published in
Current Opinion in Cell Biology
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PubMed
volume
35
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PubMed
page(s)
59-68
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PubMed
cites work
Nutrient-sensing mechanisms across evolution
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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
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20 March 2017
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
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PubMed Central
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A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.
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Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib
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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
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Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer
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Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization
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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
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A gene network regulating lysosomal biogenesis and function
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Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
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TSC2 mediates cellular energy response to control cell growth and survival
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20 March 2017
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
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Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation
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A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment
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Sestrins inhibit mTORC1 kinase activation through the GATOR complex
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The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
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PubMed Central
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
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TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
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Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3
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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
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Regulation of TORC1 by Rag GTPases in nutrient response
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MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.
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Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia
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29 September 2017
Nutrient-sensing mechanisms and pathways.
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29 September 2017
mTOR signaling in cellular and organismal energetics
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29 September 2017
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29 September 2017
The roles of microphthalmia-associated transcription factor and pigmentation in melanoma
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Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
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Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers
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Rag GTPases are cardioprotective by regulating lysosomal function.
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29 September 2017
RagA, but not RagB, is essential for embryonic development and adult mice
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The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation
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TBC1D7 mutations are associated with intellectual disability, macrocrania, patellar dislocation, and celiac disease
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29 September 2017
The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris
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29 September 2017
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
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29 September 2017
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
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mTORC1 status dictates tumor response to targeted therapeutics.
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29 September 2017
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.
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29 September 2017
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
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29 September 2017
Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease
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29 September 2017
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
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29 September 2017
A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts
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29 September 2017
Mutations of DEPDC5 cause autosomal dominant focal epilepsies
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29 September 2017
Cell biology and function of neuronal ceroid lipofuscinosis-related proteins
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29 September 2017
Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes
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PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.
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29 September 2017
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis
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29 September 2017
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529762
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29 September 2017
Targeted treatment trials for tuberous sclerosis and autism: no longer a dream
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529762
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29 September 2017
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529762
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29 September 2017
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529762
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29 September 2017
Transcriptional activation of lysosomal exocytosis promotes cellular clearance
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529762
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29 September 2017
Regulation of TFEB and V-ATPases by mTORC1.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529762
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29 September 2017
Lysosomal lipid storage diseases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529762
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29 September 2017
TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529762
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29 September 2017
The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells
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PubMed Central
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29 September 2017
Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529762
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29 September 2017
Tuberous sclerosis: from tubers to mTOR.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529762
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29 September 2017
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.
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29 September 2017
DEPDC5 mutations in genetic focal epilepsies of childhood.
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27 November 2018
Mutations in mammalian target of rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations.
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27 November 2018
Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly
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27 November 2018
Unique mutation, accelerated mTOR signaling and angiogenesis in the pulmonary cysts of Birt-Hogg-Dubé syndrome
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27 November 2018
A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.
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27 November 2018
Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin
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27 November 2018
Identifiers
DOI
10.1016/J.CEB.2015.04.014
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1180794
OpenCitations bibliographic resource ID
1180794
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1180794
PMC publication ID
4529762
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1180794
PubMed publication ID
25950843
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1180794
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