(Q34342905)

1 August 2017

title

Chemistry-based functional proteomics for drug target deconvolution (English)

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1 August 2017

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2

Tao Yang

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1 August 2017

Kui Wang

1

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1 August 2017

Qian Wu

3

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1 August 2017

Xia Zhao

4

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1 August 2017

Edouard Collins Nice

5

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1 August 2017

Canhua Huang

6

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1 August 2017

publication date

1 June 2012

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Expert Review of Proteomics

1 August 2017

published in

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1 August 2017

volume

9

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1 August 2017

issue

3

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1 August 2017

page(s)

293-310

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Target-based drug discovery: is something wrong?

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A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

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Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

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A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae

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Developing photoactive affinity probes for proteomic profiling: hydroxamate-based probes for metalloproteases.

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Profiling protein tyrosine phosphatase activity with mechanistic probes

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Activity-based probes for protein tyrosine phosphatases

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21 January 2018

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Activity-based protein profiling of host-virus interactions

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New insights into viral structure and virus-cell interactions through proteomics.

21 January 2018

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Activity-based proteome profiling of hepatoma cells during hepatitis C virus replication using protease substrate probes

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Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication

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Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe.

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21 January 2018

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Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.

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Use of multidimensional separation protocols for the purification of trace components in complex biological samples for proteomics analysis

21 January 2018

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21 January 2018

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21 January 2018

Chronic myeloid leukemia

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Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets

21 January 2018

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The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

21 January 2018

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Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

21 January 2018

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Chemical kinomics: a powerful strategy for target deconvolution

21 January 2018

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

21 January 2018

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Splicing factor SF3b as a target of the antitumor natural product pladienolide

21 January 2018

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Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation

21 January 2018

1 reference

Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division

21 January 2018

1 reference

Discovery of novel targets of quinoline drugs in the human purine binding proteome

21 January 2018

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Arsenic compounds as anticancer agents

21 January 2018

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Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

21 January 2018

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Development and application of high-performance affinity beads: toward chemical biology and drug discovery

21 January 2018

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Identification of a primary target of thalidomide teratogenicity

21 January 2018

1 reference

An immuno-chemo-proteomics method for drug target deconvolution

21 January 2018

1 reference

Capture of drug targets from live cells using a multipurpose immuno-chemo-proteomics tool

21 January 2018

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Directed immobilization of peptide ligands to accessible pore sites by conjugation with a placeholder molecule

21 January 2018

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Capture compound mass spectrometry sheds light on the molecular mechanisms of liver toxicity of two Parkinson drugs

21 January 2018

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Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins.

21 January 2018

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Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures

21 January 2018

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Targeted proteomic strategy for clinical biomarker discovery

21 January 2018

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Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.

21 January 2018

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Mass spectrometry and isotopes: a century of research and discussion

21 January 2018

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Chemical strategies for functional proteomics

21 January 2018

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Plasmodium falciparum chloroquine resistance marker protein (Pfcrmp) may be a chloroquine target protein in nucleus

21 January 2018

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Active site-directed protein regulation

21 January 2018

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Activity-Based Profiling for Drug Discovery

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/EPR.12.19

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1 August 2017

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