(Q34342905)

1 August 2017

Chemistry-based functional proteomics for drug target deconvolution (English)

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1 August 2017

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Kui Wang

1

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1 August 2017

Tao Yang

2

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1 August 2017

Qian Wu

3

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1 August 2017

Xia Zhao

4

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1 August 2017

Edouard Collins Nice

5

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1 August 2017

Canhua Huang

6

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1 August 2017

1 June 2012

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Expert Review of Proteomics

1 August 2017

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1 August 2017

9

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1 August 2017

3

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1 August 2017

293-310

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Target-based drug discovery: is something wrong?

1 August 2017

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New screens and targets in antibacterial drug discovery

21 January 2018

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Target deconvolution strategies in drug discovery

21 January 2018

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Small-molecule affinity chromatography coupled mass spectrometry for drug target deconvolution

21 January 2018

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Drug target deconvolution by chemical proteomics

21 January 2018

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Finishing the euchromatic sequence of the human genome

21 January 2018

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Drug discovery of the future: the implications of the human genome project

21 January 2018

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Initial impact of the sequencing of the human genome

21 January 2018

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Chemical proteomics applied to target identification and drug discovery

21 January 2018

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Chemical proteomics and its application to drug discovery

21 January 2018

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Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

21 January 2018

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Integrative oncoproteomics strategies for anticancer drug discovery

21 January 2018

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Advanced proteomic technologies for cancer biomarker discovery

21 January 2018

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Quantitative proteomics and biomarker discovery in human cancer

21 January 2018

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Proteomics: advances in biomarker discovery

21 January 2018

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The development and application of methods for activity-based protein profiling

21 January 2018

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Revealing promiscuous drug-target interactions by chemical proteomics.

21 January 2018

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Target profiling of small molecules by chemical proteomics

21 January 2018

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Application of chemistry-based functional proteomics to screening for novel drug targets

21 January 2018

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Activity-based probes: discovering new biology and new drug targets

21 January 2018

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Activity-based protein profiling for the functional annotation of enzymes

21 January 2018

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Tagging and detection strategies for activity-based proteomics.

21 January 2018

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ABPP methodology: introduction and overview

21 January 2018

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Biology-oriented synthesis

21 January 2018

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Small molecule microarray-facilitated screening of affinity-based probes (AfBPs) for gamma-secretase

21 January 2018

1 reference

Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites

21 January 2018

1 reference

A method for small molecule microarray-based screening for the rapid discovery of affinity-based probes

21 January 2018

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Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes.

21 January 2018

1 reference

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

Proteomic profiling of metalloprotease activities with cocktails of active-site probes

21 January 2018

1 reference

Activity-based protein profiling: new developments and directions in functional proteomics.

21 January 2018

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Application of activity-based probes to the study of enzymes involved in cancer progression

21 January 2018

1 reference

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry

21 January 2018

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The growing impact of click chemistry on drug discovery

21 January 2018

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Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

21 January 2018

1 reference

Profiling enzyme activities in vivo using click chemistry methods

21 January 2018

1 reference

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

21 January 2018

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An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

21 January 2018

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Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

21 January 2018

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A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis

21 January 2018

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Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

21 January 2018

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Unraveling the role of proteases in cancer

21 January 2018

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Protease inhibitors: current status and future prospects

21 January 2018

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Activity-based protein profiling for biochemical pathway discovery in cancer

21 January 2018

1 reference

Activity-based probes as a tool for functional proteomic analysis of proteases.

21 January 2018

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Activity based chemical proteomics: profiling proteases as drug targets

21 January 2018

1 reference

Activity-based protein profiling: the serine hydrolases

21 January 2018

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Profiling serine hydrolase activities in complex proteomes

21 January 2018

1 reference

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

21 January 2018

1 reference

RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia

21 January 2018

1 reference

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

21 January 2018

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Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

21 January 2018

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Activity-based probes that target diverse cysteine protease families

21 January 2018

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Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes

21 January 2018

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Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

21 January 2018

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Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases

21 January 2018

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Putting proteomics on target: activity-based profiling of ubiquitin and ubiquitin-like processing enzymes

21 January 2018

1 reference

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

21 January 2018

1 reference

A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L

21 January 2018

1 reference

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

21 January 2018

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Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins

21 January 2018

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A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

21 January 2018

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Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

21 January 2018

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A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae

21 January 2018

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Developing photoactive affinity probes for proteomic profiling: hydroxamate-based probes for metalloproteases.

21 January 2018

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Activity-based probes for the proteomic profiling of metalloproteases

21 January 2018

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Activity-based probes for proteomic profiling of histone deacetylase complexes

21 January 2018

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Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes

21 January 2018

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The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling

21 January 2018

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Drug discovery and protein tyrosine phosphatases.

21 January 2018

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The protein kinase complement of the human genome

21 January 2018

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Evolution of protein kinase signaling from yeast to man

21 January 2018

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Affinity labeling of purine nucleotide sites in proteins

21 January 2018

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Functional interrogation of the kinome using nucleotide acyl phosphates

21 January 2018

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A cell-permeable, activity-based probe for protein and lipid kinases

21 January 2018

1 reference

Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects.

21 January 2018

1 reference

Design and synthesis of AX7574: a microcystin-derived, fluorescent probe for serine/threonine phosphatases

21 January 2018

1 reference

Profiling protein tyrosine phosphatase activity with mechanistic probes

21 January 2018

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Activity-based protein profiling of protein tyrosine phosphatases

21 January 2018

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Activity-based probes for protein tyrosine phosphatases

21 January 2018

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Insights into host responses against pathogens from transcriptional profiling.

21 January 2018

1 reference

Activity-based protein profiling of host-virus interactions

21 January 2018

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New insights into viral structure and virus-cell interactions through proteomics.

21 January 2018

1 reference

21 January 2018

1 reference

Activity-based proteome profiling of hepatoma cells during hepatitis C virus replication using protease substrate probes

21 January 2018

1 reference

Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication

21 January 2018

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Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe.

21 January 2018

1 reference

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

21 January 2018

1 reference

Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.

21 January 2018

1 reference

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe.

21 January 2018

1 reference

Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy

21 January 2018

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Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo

21 January 2018

1 reference

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

21 January 2018

1 reference

Activity-based proteome profiling of potential cellular targets of Orlistat--an FDA-approved drug with anti-tumor activities

21 January 2018

1 reference

Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus

21 January 2018

1 reference

Beta-lactams as selective chemical probes for the in vivo labeling of bacterial enzymes involved in cell wall biosynthesis, antibiotic resistance, and virulence.

21 January 2018

1 reference

Beta-lactam probes as selective chemical-proteomic tools for the identification and functional characterization of resistance associated enzymes in MRSA.

21 January 2018

1 reference

Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.

21 January 2018

1 reference

Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes

21 January 2018

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A tandem orthogonal proteolysis strategy for high-content chemical proteomics

21 January 2018

1 reference

Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery

21 January 2018

1 reference

Dynamic imaging of protease activity with fluorescently quenched activity-based probes.

21 January 2018

1 reference

Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.

21 January 2018

1 reference

Use of multidimensional separation protocols for the purification of trace components in complex biological samples for proteomics analysis

21 January 2018

1 reference

Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography

21 January 2018

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Comparative plasma membrane-associated proteomics of immortalized human hepatocytes

21 January 2018

1 reference

Proteomic methods for drug target discovery

21 January 2018

1 reference

A versatile method of identifying specific binding proteins on affinity resins.

21 January 2018

1 reference

Kinase selectivity profiling by inhibitor affinity chromatography

21 January 2018

1 reference

An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

21 January 2018

1 reference

Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling.

21 January 2018

1 reference

Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors

21 January 2018

1 reference

Roscovitine targets, protein kinases and pyridoxal kinase

21 January 2018

1 reference

21 January 2018

Chronic myeloid leukemia

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Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets

21 January 2018

1 reference

The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

21 January 2018

1 reference

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

21 January 2018

1 reference

Chemical kinomics: a powerful strategy for target deconvolution

21 January 2018

1 reference

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

1 reference

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

21 January 2018

1 reference

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

21 January 2018

1 reference

Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation

21 January 2018

1 reference

Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division

21 January 2018

1 reference

Discovery of novel targets of quinoline drugs in the human purine binding proteome

21 January 2018

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Arsenic compounds as anticancer agents

21 January 2018

1 reference

Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

21 January 2018

1 reference

Development and application of high-performance affinity beads: toward chemical biology and drug discovery

21 January 2018

1 reference

Identification of a primary target of thalidomide teratogenicity

21 January 2018

1 reference

An immuno-chemo-proteomics method for drug target deconvolution

21 January 2018

1 reference

Capture of drug targets from live cells using a multipurpose immuno-chemo-proteomics tool

21 January 2018

1 reference

Directed immobilization of peptide ligands to accessible pore sites by conjugation with a placeholder molecule

21 January 2018

1 reference

Capture compound mass spectrometry sheds light on the molecular mechanisms of liver toxicity of two Parkinson drugs

21 January 2018

1 reference

Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins.

21 January 2018

1 reference

Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures

21 January 2018

1 reference

Targeted proteomic strategy for clinical biomarker discovery

21 January 2018

1 reference

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.

21 January 2018

1 reference

Mass spectrometry and isotopes: a century of research and discussion

21 January 2018

1 reference

Chemical strategies for functional proteomics

21 January 2018

1 reference

Plasmodium falciparum chloroquine resistance marker protein (Pfcrmp) may be a chloroquine target protein in nucleus

21 January 2018

1 reference

Active site-directed protein regulation

21 January 2018

1 reference

Activity-Based Profiling for Drug Discovery

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/EPR.12.19

1 reference

1 August 2017

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