(Q34406072)

2 August 2017

title

p53: the barrier to cancer stem cell formation. (English)

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2 August 2017

main subject

neoplastic stem cells

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4

Varda Rotter

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2 August 2017

author name string

Ronit Aloni-Grinstein

series ordinal

1

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2 August 2017

Yoav Shetzer

series ordinal

2

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2 August 2017

Tom Kaufman

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

19 February 2014

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2 August 2017

number of pages

10

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based on heuristic

inferred from page(s)

published in

FEBS Letters

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2 August 2017

volume

588

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2 August 2017

issue

16

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2 August 2017

page(s)

2580-2589

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Cancer. p53, guardian of the genome

2 August 2017

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21 January 2018

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21 January 2018

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Regulation of p53 is critical for vertebrate limb regeneration

21 January 2018

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Induced pluripotency and oncogenic transformation are related processes

21 January 2018

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An embryo protein induced by SV40 virus transformation of mouse cells

21 January 2018

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Quantitation and characterization of a species-specific and embryo stage-dependent 55-kilodalton phosphoprotein also present in cells transformed by simian virus 40

21 January 2018

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21 January 2018

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21 January 2018

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SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization

21 January 2018

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p53 is required for etoposide-induced apoptosis of human embryonic stem cells

21 January 2018

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ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

21 January 2018

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p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Polycomb group protein-mediated repression of transcription

21 January 2018

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Targeted deletion reveals an essential function for the telomere length regulator Trf1.

21 January 2018

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Senescence impairs successful reprogramming to pluripotent stem cells

21 January 2018

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Suppression of induced pluripotent stem cell generation by the p53-p21 pathway

21 January 2018

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Linking the p53 tumour suppressor pathway to somatic cell reprogramming

21 January 2018

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The Ink4/Arf locus is a barrier for iPS cell reprogramming

21 January 2018

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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

21 January 2018

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Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

21 January 2018

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Effective generation of iPS cells from CD34+ cord blood cells by inhibition of p53.

21 January 2018

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Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells

21 January 2018

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p53 connects tumorigenesis and reprogramming to pluripotency

21 January 2018

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Direct cell reprogramming is a stochastic process amenable to acceleration

21 January 2018

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p53-facilitated miR-199a-3p regulates somatic cell reprogramming.

21 January 2018

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The p53-PUMA axis suppresses iPSC generation

21 January 2018

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Role of the murine reprogramming factors in the induction of pluripotency

21 January 2018

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Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation.

21 January 2018

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Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Modeling sarcomagenesis using multipotent mesenchymal stem cells

21 January 2018

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Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo.

21 January 2018

1 reference

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The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development.

21 January 2018

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Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model

21 January 2018

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Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

21 January 2018

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High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas

21 January 2018

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Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland

21 January 2018

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An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

21 January 2018

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Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.

21 January 2018

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Molecular classification of prostate cancer using curated expression signatures

21 January 2018

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Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression

21 January 2018

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

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21 January 2018

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Methylation in the p53 promoter is a supplementary route to breast carcinogenesis: correlation between CpG methylation in the p53 promoter and the mutation of the p53 gene in the progression from ductal carcinoma in situ to invasive ductal carcinoma

21 January 2018

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Abnormal expression of MDM2 in prostate carcinoma.

21 January 2018

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Unique substitution of CHEK2 and TP53 mutations implicated in primary prostate tumors and cancer cell lines

21 January 2018

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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis

21 January 2018

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p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways.

21 January 2018

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Haplo-insufficiency: a driving force in cancer

21 January 2018

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

21 January 2018

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Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency

21 January 2018

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Treatment of acute promyelocytic leukemia: strategy toward further increase of cure rate

21 January 2018

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Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group

21 January 2018

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Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

21 January 2018

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

21 January 2018

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An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

21 January 2018

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Histone deacetylase inhibitors: an attractive strategy for cancer therapy

21 January 2018

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MicroRNAs as novel regulators of stem cell fate

21 January 2018

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microRNA-34a is tumor suppressive in brain tumors and glioma stem cells

21 January 2018

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MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma

21 January 2018

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miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

21 January 2018

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Stable reintroduction of wild-type P53 (MTmp53ts) causes the induction of apoptosis and neuroendocrine-like differentiation in human ductal pancreatic carcinoma cells

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Hedgehog pathway activation in chronic myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Cancer stem cells: current status and evolving complexities

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

21 January 2018

1 reference

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Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop

21 January 2018

1 reference

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Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Loss of p53 exacerbates multiple myeloma phenotype by facilitating the reprogramming of hematopoietic stem/progenitor cells to malignant plasma cells by MafB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

"Dedifferentiation" and high-grade transformation in salivary gland carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Genetic alterations in poorly differentiated and undifferentiated thyroid carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2014.02.011

Genetic alterations in thyroid tumor progression: association with p53 gene mutations.

21 January 2018

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Bilateral wilms tumor with TP53-related anaplasia.

21 January 2018

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The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma.

21 January 2018

1 reference

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Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus

21 January 2018

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Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation

21 January 2018

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21 January 2018

Identifiers

DOI

1 reference

2 August 2017

1 reference