(Q34430920)

2 August 2017

title

Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice (English)

1 reference

2 August 2017

9

Terrence Town

1 reference

2 August 2017

8

Jun Tan

1 reference

2 August 2017

1

Takashi Mori

1 reference

2 August 2017

Naoki Koyama

2

1 reference

2 August 2017

Tatsuya Segawa

3

1 reference

2 August 2017

Masahiro Maeda

4

1 reference

2 August 2017

Nobuhiro Maruyama

5

1 reference

2 August 2017

Noriaki Kinoshita

6

1 reference

2 August 2017

Huayan Hou

7

1 reference

2 August 2017

language of work or name

English

0 references

publication date

25 August 2014

1 reference

Journal of Biological Chemistry

2 August 2017

published in

1 reference

2 August 2017

volume

289

1 reference

2 August 2017

issue

44

1 reference

2 August 2017

page(s)

30303-30317

1 reference

Targeting the β secretase BACE1 for Alzheimer's disease therapy

2 August 2017

cites work

1 reference

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Therapeutic and preventive effects of methylene blue on Alzheimer's disease pathology in a transgenic mouse model

6 July 2018

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Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice

6 July 2018

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Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice

6 July 2018

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β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects

6 July 2018

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β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

6 July 2018

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Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

6 July 2018

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Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice

6 July 2018

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"Lest we forget you--methylene blue...".

6 July 2018

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Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors

6 July 2018

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Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity

6 July 2018

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The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

6 July 2018

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Cellular and molecular actions of Methylene Blue in the nervous system

6 July 2018

1 reference

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Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease

6 July 2018

1 reference

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A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

High absolute bioavailability of methylene blue given as an aqueous oral formulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Control of peripheral nerve myelination by the beta-secretase BACE1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

A specific amyloid-beta protein assembly in the brain impairs memory

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

BACE (beta-secretase) modulates the processing of APLP2 in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Phencyclidine-induced behaviour in mice prevented by methylene blue

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Alzheimer's disease: genes, proteins, and therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Methods for projecting the incidence and prevalence of chronic diseases in aging populations: application to Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Cellular mechanisms of beta-amyloid production and secretion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Hippocampal morphology and open-field behavior in Mus musculus domesticus and Mus spretus inbred mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Evolution of science-based uncertainty factors in noncancer risk assessment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Methylene blue. A possible treatment for manic depressive psychosis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Pharmacokinetics of Highly Ionized Drugs II: Methylene Blue—Absorption, Metabolism, and Excretion in Man and Dog after Oral Administration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manic-depressive psychosis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Drugs: a tangled web of targets.

6 July 2018

1 reference

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Memory facilitation by methylene blue: dose-dependent effect on behavior and brain oxygen consumption.

21 January 2018

1 reference

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Hope in Alzheimer's fight emerges from unexpected places

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Challenges in the conduct of disease-modifying trials in AD: practical experience from a phase 2 trial of Tau-aggregation inhibitor therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Optimization of chronic stress paradigms using anxiety- and depression-like behavioral parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Arundic Acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Pharmacokinetics and organ distribution of intravenous and oral methylene blue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.568212

Methylene blue supravital staining: an evaluation of its applicability to the mammalian brain and pineal gland.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215215

Reference dose (RfD): description and use in health risk assessments

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25157105

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.568212

1 reference

2 August 2017

1 reference

2 August 2017

1 reference