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Pharmacologic Means of Extending Lifespan.
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scholarly article
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Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
title
Pharmacologic Means of Extending Lifespan
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
main subject
lifetime
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inferred from title
author
Dudley W Lamming
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
David M. Sabatini
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2
object named as
David M Sabatini
1 reference
stated in
Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
author name string
Joseph A Baur
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3
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Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
publication date
1 May 2012
1 reference
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Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
published in
Journal of clinical & experimental pathology
1 reference
stated in
Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
volume
Suppl 4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
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SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53.
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6 July 2018
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Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
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Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.
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6 July 2018
Oral resveratrol reduces neuronal damage in a model of multiple sclerosis
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6 July 2018
Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver
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6 July 2018
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
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6 July 2018
Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice
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6 July 2018
Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells
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6 July 2018
Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae
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Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis
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Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans
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6 July 2018
Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR
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6 July 2018
Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production
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6 July 2018
SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator
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6 July 2018
RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.
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6 July 2018
Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3
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6 July 2018
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
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6 July 2018
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
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6 July 2018
Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
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6 July 2018
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
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6 July 2018
SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts
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6 July 2018
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
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6 July 2018
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
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6 July 2018
Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.
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6 July 2018
Metformin supplementation and life span in Fischer-344 rats
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6 July 2018
Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
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6 July 2018
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments
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6 July 2018
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
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6 July 2018
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy
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6 July 2018
Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
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6 July 2018
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
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6 July 2018
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
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6 July 2018
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
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PubMed Central
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6 July 2018
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
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6 July 2018
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
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6 July 2018
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
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6 July 2018
Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
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PubMed Central
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6 July 2018
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study
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6 July 2018
Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype
1 reference
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PubMed Central
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6 July 2018
Induction of autophagy by spermidine promotes longevity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
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6 July 2018
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
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6 July 2018
Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway
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PubMed Central
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6 July 2018
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
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PubMed Central
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6 July 2018
Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
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6 July 2018
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
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6 July 2018
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
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6 July 2018
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6 July 2018
Metformin--the gold standard in type 2 diabetes: what does the evidence tell us?
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6 July 2018
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
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6 July 2018
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
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6 July 2018
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6 July 2018
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
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6 July 2018
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
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6 July 2018
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6 July 2018
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
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6 July 2018
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6 July 2018
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
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6 July 2018
Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver
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6 July 2018
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6 July 2018
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
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6 July 2018
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
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6 July 2018
AMPK phosphorylation of raptor mediates a metabolic checkpoint
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6 July 2018
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6 July 2018
Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells
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6 July 2018
Sirolimus is associated with new-onset diabetes in kidney transplant recipients.
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6 July 2018
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
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6 July 2018
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
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6 July 2018
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
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6 July 2018
Dose translation from animal to human studies revisited
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6 July 2018
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
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6 July 2018
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.
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6 July 2018
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
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6 July 2018
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
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6 July 2018
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
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6 July 2018
Brain IRS2 signaling coordinates life span and nutrient homeostasis
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6 July 2018
Resveratrol is a class IA phosphoinositide 3-kinase inhibitor
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6 July 2018
Two neurons mediate diet-restriction-induced longevity in C. elegans
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6 July 2018
Resveratrol stimulates AMP kinase activity in neurons
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6 July 2018
Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview
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6 July 2018
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
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6 July 2018
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
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6 July 2018
Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial
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6 July 2018
Resveratrol improves health and survival of mice on a high-calorie diet
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6 July 2018
Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
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6 July 2018
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
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6 July 2018
Therapeutic potential of resveratrol: the in vivo evidence
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6 July 2018
Resveratrol inhibits insulin responses in a SirT1-independent pathway
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6 July 2018
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
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6 July 2018
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.
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6 July 2018
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
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6 July 2018
Identification of potential caloric restriction mimetics by microarray profiling
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6 July 2018
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
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6 July 2018
Mechanism of human SIRT1 activation by resveratrol
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6 July 2018
Substrate-specific activation of sirtuins by resveratrol
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6 July 2018
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
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6 July 2018
Life extension in the dwarf mouse
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6 July 2018
Crystal structure of quinone reductase 2 in complex with resveratrol
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6 July 2018
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
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6 July 2018
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
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6 July 2018
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
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6 July 2018
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6 July 2018
TSC2 mediates cellular energy response to control cell growth and survival
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6 July 2018
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6 July 2018
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
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6 July 2018
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
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6 July 2018
Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2.
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6 July 2018
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6 July 2018
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6 July 2018
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6 July 2018
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
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6 July 2018
Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase
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6 July 2018
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6 July 2018
Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor
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6 July 2018
Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor
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6 July 2018
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6 July 2018
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6 July 2018
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6 July 2018
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6 July 2018
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27 October 2018
Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients.
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27 October 2018
Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation
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Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation
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27 October 2018
Dietary energy balance modulates signaling through the Akt/mammalian target of rapamycin pathways in multiple epithelial tissues
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
Metformin slows down aging and extends life span of female SHR mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
Metformin therapy in a transgenic mouse model of Huntington's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
A novel assay for replicative lifespan in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
Effects of resveratrol on the rat brain respiratory chain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
27 October 2018
S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219537
retrieved
9 December 2018
Identifiers
DOI
10.4172/2161-0681.S4-002
1 reference
stated in
Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
Fatcat ID
release_dvhx7quvgvbqva5ajsd6qpxy2e
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/dvhx7quvgvbqva5ajsd6qpxy2e
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
PMC publication ID
4219537
1 reference
stated in
Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
PubMed publication ID
25379357
1 reference
stated in
Europe PubMed Central
PMC publication ID
4219537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25379357%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
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