(Q34509775)

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Metabolism of presenilins

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scholarly article

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

Metabolism of presenilins (English)

1 reference

Europe PubMed Central

2 August 2017

author name string

Thinakaran G

1

1 reference

Europe PubMed Central

2 August 2017

publication date

1 October 2001

1 reference

Europe PubMed Central

2 August 2017

Journal of Molecular Neuroscience

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Europe PubMed Central

2 August 2017

17

1 reference

Europe PubMed Central

2 August 2017

2

1 reference

Europe PubMed Central

2 August 2017

183-192

1 reference

Europe PubMed Central

2 August 2017

https://scigraph.springernature.com/pub.10.1385/jmn:17:2:183

0 references

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different effects of Alzheimer-associated mutations of presenilin 1 on its processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilin 1 C92S mutation increases abeta 42 production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular distribution and turnover of presenilins in transfected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of presenilin N-terminal fragments on production of amyloid beta peptide and accumulation of endogenous presenilins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboxyl-terminal fragments of presenilin-1 are closely related to cytoskeletal abnormalities in Alzheimer's brains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is actively degraded by the 26S proteasome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins are processed by caspase-type proteases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic processing and degradation of human presenilin-1 expressed in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of endoproteolysis but no effects on amyloid beta production by alternative splicing forms of presenilin-1, which lack exon 8 and replace D257A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane topology of the C. elegans SEL-12 presenilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired proteolytic processing of presenilin-1 in chromosome 14-linked familial Alzheimer's disease patient lymphocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual roles of proteasome in the metabolism of presenilin 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11816791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/JMN:17:2:183

1 reference

Europe PubMed Central

2 August 2017

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0 references

1 reference

Europe PubMed Central

2 August 2017

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