(Q35030005)

5 August 2017

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title

Inflammation and therapeutic vaccination in CNS diseases (English)

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5 August 2017

2

Dennis J Selkoe

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5 August 2017

Howard L Weiner

1

1 reference

PubMed ID

12490962

5 August 2017

language of work or name

English

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publication date

1 December 2002

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5 August 2017

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5 August 2017

420

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5 August 2017

879-884

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5 August 2017

6917

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https://scigraph.springernature.com/pub.10.1038/nature01325

5 August 2017

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cites work

The role of magnetic resonance techniques in understanding and managing multiple sclerosis

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Effect of open label pulse cyclophosphamide therapy on MRI measures of disease activity in five patients with refractory relapsing-remitting multiple sclerosis.

21 January 2018

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Treatment of multiple sclerosis with cyclophosphamide: critical review of clinical and immunologic effects

21 January 2018

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Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines

21 January 2018

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The expanding universe of T-cell subsets: Th1, Th2 and more.

21 January 2018

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Regulatory T cells in the control of immune pathology.

21 January 2018

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A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE01325

Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE01325

CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE01325

Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MS

21 January 2018

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The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease

21 January 2018

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE01325

Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia

21 January 2018

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Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

21 January 2018

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Mechanisms of action of glatiramer acetate in multiple sclerosis

21 January 2018

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Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease

21 January 2018

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TCR peptide therapy in human autoimmune diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE01325

Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE01325

Plasmid DNA encoding IFN-gamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis

21 January 2018

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Inflammation and Alzheimer's disease

21 January 2018

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The importance of inflammatory mechanisms in Alzheimer disease.

21 January 2018

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Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

21 January 2018

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Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

21 January 2018

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Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

21 January 2018

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

21 January 2018

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Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

21 January 2018

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Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease

21 January 2018

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Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE01325

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

21 January 2018

1 reference

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Induction of a non-encephalitogenic type 2 T helper-cell autoimmune responsein multiple sclerosis after administration of an altered peptide ligand ina placebo-controlled, randomized phase II trial

21 January 2018

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Serial magnetic resonance imaging in multiple sclerosis: correlation with attacks, disability, and disease stage

21 January 2018

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7 January 2021

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis

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https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

A 21 point unifying hypothesis on the etiology and treatment of multiple sclerosis.

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7 January 2021

Clinical viral infections and multiple sclerosis.

1 reference

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7 January 2021

Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Exacerbations of multiple sclerosis in patients treated with gamma interferon

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

IL-18 is linked to raised IFN-gamma in multiple sclerosis and is induced by activated CD4(+) T cells via CD40-CD40 ligand interactions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Cutting edge: Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Antigen-driven bystander suppression after oral administration of antigens

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

T-cell vaccination: from basics to the clinic

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Depletion of myelin-basic-protein autoreactive T cells by T-cell vaccination: pilot trial in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

A targeted DNA vaccine encoding fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Key issues in Alzheimer's disease inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01325

7 January 2021

Identifiers

DOI

10.1038/NATURE01325

1 reference

PubMed ID

12490962

Dimensions Publication ID

5 August 2017

0 references

1 reference

PubMed ID

12490962