(Q35129369)

6 August 2017

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title

Vaccines for Alzheimer's disease: how close are we? (English)

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6 August 2017

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Christopher Janus

1

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6 August 2017

publication date

1 January 2003

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6 August 2017

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6 August 2017

volume

17

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6 August 2017

issue

7

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6 August 2017

page(s)

457-474

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https://scigraph.springernature.com/pub.10.2165/00023210-200317070-00001

6 August 2017

exact match

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cites work

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A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.

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Blood-brain barrier transport of circulating Alzheimer's amyloid beta

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Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice

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Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

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12 December 2020

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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12 December 2020

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New developments in animal models of Alzheimer's disease

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Physical aggression is associated with preservation of substantia nigra pars compacta in Alzheimer disease

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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Single and multiple transgenic mice as models for Alzheimer's disease

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Neurodegenerative disorders with extensive tau pathology: a comparative study and review

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Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported.

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Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

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Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

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Alzheimer's disease: genetic studies and transgenic models

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12 December 2020

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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12 December 2020

Immunization with beta-amyloid: could T-cell activation have a harmful effect?

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12 December 2020

Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein

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12 December 2020

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

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12 December 2020

The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution.

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12 December 2020

The generation and characterization of potentially therapeutic Abeta antibodies in mice: differences according to strain and immunization protocol

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12 December 2020

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12 December 2020

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1

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12 December 2020

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

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12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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12 December 2020

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

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12 December 2020

Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study

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12 December 2020

Cholesterol and Alzheimer's disease: is there a link?

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12 December 2020

What transgenic mice tell us about neurodegenerative disease

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12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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12 December 2020

Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

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12 December 2020

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

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12 December 2020

Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease

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12 December 2020

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12 December 2020

Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning

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12 December 2020

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12 December 2020

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12 December 2020

Amyloid fibril toxicity in Alzheimer's disease and diabetes

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12 December 2020

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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12 December 2020

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12 December 2020

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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12 December 2020

Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia

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12 December 2020

Mutations of the presenilin I gene in families with early-onset Alzheimer's disease

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12 December 2020

The human life span: are we reaching the outer limits?

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12 December 2020

Transgenic animals relevant to Alzheimer's disease

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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12 December 2020

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

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12 December 2020

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

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12 December 2020

Transgenic mouse models of Alzheimer's disease

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12 December 2020

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

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12 December 2020

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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12 December 2020

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

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12 December 2020

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

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12 December 2020

Transgenic mouse models of Alzheimer's disease

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12 December 2020

The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

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12 December 2020

Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain.

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12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

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12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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12 December 2020

10.2165/00023210-200317070-00001

Identifiers

DOI

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Dimensions Publication ID

6 August 2017

1041900051

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