(Q35168349)

6 August 2017

Polyphenols as therapeutic molecules in Alzheimer's disease through modulating amyloid pathways (English)

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6 August 2017

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Johant Lakey-Beitia

1

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6 August 2017

Ruben Berrocal

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2

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6 August 2017

K S Rao

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3

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6 August 2017

Armando A Durant

series ordinal

4

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6 August 2017

15 May 2014

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6 August 2017

Molecular Neurobiology

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6 August 2017

51

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6 August 2017

2

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6 August 2017

466-479

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https://scigraph.springernature.com/pub.10.1007/s12035-014-8722-9

6 August 2017

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Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease

21 January 2018

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Review of theoretical studies for prediction of neurodegenerative inhibitors.

21 January 2018

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Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.

21 January 2018

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Targets for AD treatment: conflicting messages from γ-secretase inhibitors

21 January 2018

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New evidences on Tau-DNA interactions and relevance to neurodegeneration.

21 January 2018

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Amyloid and tau imaging, neuronal losses and function in mild cognitive impairment

21 January 2018

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Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide

21 January 2018

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Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid beta precursor protein

21 January 2018

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Clinical trials in predementia stages of Alzheimer disease

21 January 2018

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Treatment strategies targeting amyloid β-protein

21 January 2018

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Biomarker discovery in neurodegenerative diseases: a proteomic approach.

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Molecular and biochemical features in Alzheimer's disease

21 January 2018

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Neuroprotective potential of phytochemicals

21 January 2018

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Potential therapeutic agents against Alzheimer's disease from natural sources

21 January 2018

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A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo

21 January 2018

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Advances in flavonoid research since 1992.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Polyphenol contents and radical scavenging capacities of red maple (Acer rubrum L.) extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Effect of antioxidant flavanone, naringenin, from Citrus junoson neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Anti-inflammatory activity of a honey flavonoid extract on lipopolysaccharide-activated N13 microglial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Identification and characterization of polyphenolic antioxidants using on-line liquid chromatography, electrochemistry, and electrospray ionization tandem mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Optimization of a new mobile phase to know the complex and real polyphenolic composition: towards a total phenolic index using high-performance liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Engineered polyketide biosynthesis and biocatalysis in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Dietary flavonoids: bioavailability, metabolic effects, and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Structure-activity relationships of flavonoids in the cellular antioxidant activity assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Effects of natural flavones and flavonols on the kinase activity of Cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Advanced separation methods of food anthocyanins, isoflavones and flavanols

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Anthocyanins present in selected tropical fruits: acerola, jambolão, jussara, and guajiru

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Anthocyanin-rich purple wheat prolongs the life span of Caenorhabditis elegans probably by activating the DAF-16/FOXO transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Protective effects of anthocyanins against amyloid β-peptide-induced damage in neuro-2A cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Regulation of β cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

A portrait of Alzheimer secretases--new features and familiar faces

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Alzheimer's disease: channeling APP to non-amyloidogenic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Beta-secretase: structure, function, and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Previously not recognized deletion in presenilin-1 (p.Leu174del.) in a patient with early-onset familial Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

The binding of resveratrol to monomer and fibril amyloid beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Regulation of α-secretase ADAM10 expression and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

The ADAM metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Activation of α-secretase by curcumin-aminoacid conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Crystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid Protein Production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Assigning the protonation states of the key aspartates in β-Secretase using QM/MM X-ray structure refinement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

The presenilins in Alzheimer's disease--proteolysis holds the key.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

An azobenzene photoswitch sheds light on turn nucleation in amyloid-β self-assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Structure-activity relationships in peptide modulators of β-amyloid protein aggregation: variation in α,α-disubstitution results in altered aggregate size and morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Molecular structures of amyloid and prion fibrils: consensus versus controversy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Tanshinones inhibit amyloid aggregation by amyloid-β peptide, disaggregate amyloid fibrils, and protect cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Amyloid probes based on Congo Red distinguish between fibrils comprising different peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Plasticity of amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Intrinsic structural heterogeneity and long-term maturation of amyloid β peptide fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Effects of peptides derived from terminal modifications of the aβ central hydrophobic core on aβ fibrillization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Liberation of copper from amyloid plaques: making a risk factor useful for Alzheimer's disease treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Anti-amyloidogenic activity of S-allyl-L-cysteine and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Self-assembly of Abeta(1-42) into globular neurotoxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

A disulfide-linked amyloid-beta peptide dimer forms a protofibril-like oligomer through a distinct pathway from amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Alzheimer's disease: strategies for disease modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Dual effect of amino modified polystyrene nanoparticles on amyloid β protein fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Aggregation properties of a short peptide that mediates amyloid fibril formation in model proteins unrelated to disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Localization of the noncovalent binding site between amyloid-beta-peptide and oleuropein using electrospray ionization FT-ICR mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

(-)-epigallocatechin-3-gallate (EGCG) maintains kappa-casein in its pre-fibrillar state without redirecting its aggregation pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

"Clicked" sugar-curcumin conjugate: modulator of amyloid-β and tau peptide aggregation at ultralow concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

The polyphenol piceid destabilizes preformed amyloid fibrils and oligomers in vitro: hypothesis on possible molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

A safe, blood-brain barrier permeable triphenylmethane dye inhibits amyloid-β neurotoxicity by generating nontoxic aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

New polyphenols active on beta-amyloid aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Polyphenol-induced dissociation of various amyloid fibrils results in a methionine-independent formation of ROS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Carboxymethylated-kappa-casein: a convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Inhibitory activity of stilbenes on Alzheimer's beta-amyloid fibrils in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

New stilbene dimers against amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Anti-amyloidogenic effects of antioxidants: implications for the prevention and therapeutics of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

The development of preventives and therapeutics for Alzheimer's disease that inhibit the formation of beta-amyloid fibrils (fAbeta), as well as destabilize preformed fAbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Congo red and protein aggregation in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol ε-viniferin glucoside: implications in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Bioavailability of the polyphenols: status and controversies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Anti-amyloidogenic property of leaf aqueous extract of Caesalpinia crista

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Polyphenol constituents and antioxidant activity of grape pomace extracts from five Sicilian red grape cultivars

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8722-9

Conformational transition in the substrate binding domain of β-secretase exploited by NMA and its implication in inhibitor recognition: BACE1-myricetin a case study

21 January 2018

1 reference

12 December 2020

Frontiers in the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease?

1 reference

12 December 2020

Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat.

1 reference

12 December 2020

Emerging therapeutics for Alzheimer's disease

1 reference

12 December 2020

Effect of the citrus flavanone naringenin on oxidative stress in rats

1 reference

12 December 2020

Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword

1 reference

12 December 2020

Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.

1 reference

12 December 2020

Flavonoid content of U.S. fruits, vegetables, and nuts

1 reference

12 December 2020

9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation?

1 reference

12 December 2020

Neuronutrition and Alzheimer's disease

1 reference

12 December 2020

Challenges associated with metal chelation therapy in Alzheimer's disease

1 reference

12 December 2020

A possible role for pi-stacking in the self-assembly of amyloid fibrils

1 reference

12 December 2020

Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases

1 reference

12 December 2020

Value in development of a TAPIR-like mouse monoclonal antibody to Abeta.

1 reference

12 December 2020

Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma.

1 reference

12 December 2020

Differential accumulation of secreted AbetaPP metabolites in ocular fluids

1 reference

12 December 2020

Exploring the inhibitory activity of short-chain phospholipids against amyloid fibrillogenesis of hen egg-white lysozyme

1 reference

12 December 2020

Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta.

1 reference

12 December 2020

The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.

1 reference

12 December 2020

Polyphenols: food sources and bioavailability

1 reference

12 December 2020

Critical evaluation of biodegradable polymers used in nanodrugs

1 reference

12 December 2020

Antioxidant activity and polyphenol content in cultivated and wild edible fruits grown in Panama

1 reference

12 December 2020

The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure

1 reference

12 December 2020

Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate

1 reference

12 December 2020

Upregulation of the alpha-secretase ADAM10--risk or reason for hope?

1 reference

12 December 2020

Systematic analysis of the content of 502 polyphenols in 452 foods and beverages: an application of the phenol-explorer database

1 reference

12 December 2020

Apricot carotenoids possess potent anti-amyloidogenic activity in vitro

1 reference

12 December 2020

In vitro evidence that an aqueous extract of Centella asiatica modulates α-synuclein aggregation dynamics

1 reference

12 December 2020

Targeting oligomers in neurodegenerative disorders: lessons from α-synuclein, tau, and amyloid-β peptide

1 reference

12 December 2020

10.1007/S12035-014-8722-9

Identifiers

DOI

1 reference

6 August 2017

1 reference