(Q35214619)

7 August 2017

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title

Differential effects of cell cycle regulatory protein p21(WAF1/Cip1) on apoptosis and sensitivity to cancer chemotherapy (English)

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7 August 2017

1 reference

1 reference

Suxing Liu

1

1 reference

PubMed ID

12962684

7 August 2017

W Robert Bishop

series ordinal

2

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PubMed ID

12962684

7 August 2017

Ming Liu

series ordinal

3

1 reference

7 August 2017

1 August 2003

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7 August 2017

Drug Resistance Updates

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7 August 2017

6

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7 August 2017

4

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7 August 2017

183-195

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Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis

7 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Hair and cancer chemotherapy: consequences and nursing care--a literature study

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Apoptosis: mediator or mode of cell killing by anticancer agents?

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Targeting the cell cycle for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Cyclin-binding motifs are essential for the function of p21CIP1

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Control of E2F activity by p21Waf1/Cip1

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

E2F-1 overexpression sensitizes colorectal cancer cells to camptothecin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

E2F-1 gene therapy induces apoptosis and increases chemosensitivity in human pancreatic carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Proliferation, cell cycle and apoptosis in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Secondary leukemias induced by topoisomerase-targeted drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

p53 as a therapeutic target: unresolved issues on the road to cancer therapy targeting mutant p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Transcriptional Regulation of the p21(WAF1/CIP1)Gene

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

A role for E2F1 in Ras activation of p21(WAF1/CIP1) transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

p21 and p53 in ovarian carcinoma: their combined staining is more valuable than either alone.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

E2F1 pathways to apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

1 reference

7 January 2021

The use of cyclin-dependent kinase inhibitors alone or in combination with established cytotoxic drugs in cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

A matter of life and death

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Identification of c-MYC as a target of the APC pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Identification of CDK4 as a target of c-MYC.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Induction of p21(CIP1/Waf1) and activation of p34(cdc2) involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Death and anti-death: tumour resistance to apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Reciprocal regulation via protein-protein interaction between c-Myc and p21(cip1/waf1/sdi1) in DNA replication and transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Clinical update: proteasome inhibitors in solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

p21/CDKN1A mediates negative regulation of transcription by p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Targeting apoptosis in cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Involvement of bcl-2 and p21waf1 proteins in response of human breast cancer cell clones to Tomudex

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6).

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

p21WAF1 Mutation Is Not a Predominant Alteration in Pediatric Bone Tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

p21WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

MyoD induces apoptosis in the absence of RB function through a p21(WAF1)-dependent re-localization of cyclin/cdk complexes to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Exogenous expression of p21(WAF1/CIP1) exerts cell growth inhibition and enhances sensitivity to cisplatin in hepatoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

p53-independent expression of p21(CIP1/WAF1) in plasmacytic cells during G(2) cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Apoptosis is critical for drug response in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Signaling networks that link cell proliferation and cell fate

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

A non-enzymatic p21 protein inhibitor of stress-activated protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Clinical significance of p21 expression in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Ectopic p21sdi1 gene transfer induces retinoic acid receptor beta expression and sensitizes human cancer cells to retinoid treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Inhibitor of cyclooxygenase-2 induces cell-cycle arrest in the epithelial cancer cell line via up-regulation of cyclin dependent kinase inhibitor p21

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Therapy-associated solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Sibling rivalry in the E2F family

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Transcriptional regulation during p21WAF1/CIP1-induced apoptosis in human ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Mdm2 inhibition of p53 induces E2F1 transactivation via p21.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

p21 Waf-1 (Cip-1) enhances apoptosis induced by manumycin and paclitaxel in anaplastic thyroid cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

Effects of interferon alpha on the expression of p21cip1/waf1 and cell cycle distribution in carcinoid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900044-X

7 January 2021

10.1016/S1368-7646(03)00044-X

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12962684