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The functional and pathologic relevance of autophagy proteases
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
The functional and pathologic relevance of autophagy proteases
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
main subject
autophagy
0 references
author
Carlos López Otín
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
Álvaro F. Fernández
object named as
Álvaro F Fernández
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1
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language of work or name
English
0 references
publication date
2 January 2015
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stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
published in
Journal of Clinical Investigation
1 reference
stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
volume
125
1 reference
stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
page(s)
33-41
1 reference
stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
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12 July 2018
Regulation of mammalian autophagy in physiology and pathophysiology.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Autophagy is essential for mouse sense of balance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
A balancing act for autophagin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The regulatory crosstalk between kinases and proteases in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Mammalian autophagy: core molecular machinery and signaling regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The autophagy machinery is required to initiate hepatitis C virus replication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The Degradome database: mammalian proteases and diseases of proteolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The genetics and immunopathogenesis of inflammatory bowel disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Premature aging in mice activates a systemic metabolic response involving autophagy induction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Autophagy in the Pathogenesis of Disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
FoxO3 controls autophagy in skeletal muscle in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Targeting proteases: successes, failures and future prospects
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The role of autophagy during the early neonatal starvation period
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Autophagy: molecular mechanisms, physiological functions and relevance in human pathology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
12 July 2018
Molecular mechanism of autophagic membrane-scaffold assembly and disassembly.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
26 September 2018
Autophagy gene fingerprint in human ischemia and reperfusion.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
26 September 2018
Impairment of autophagy decreases ventilator-induced lung injury by blockade of the NF-κB pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
26 September 2018
Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
26 September 2018
Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
26 September 2018
Autophagy, proteases and the sense of balance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
26 September 2018
Autophagy is involved in nutritional stress response and differentiation in Trypanosoma cruzi.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
26 September 2018
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
26 September 2018
Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
26 September 2018
Genetic variants in autophagy-related genes and granuloma formation in a cohort of surgically treated Crohn's disease patients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
15 November 2018
Targeting autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
15 November 2018
Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382236
retrieved
15 November 2018
18 kDa microtubule-associated protein: identification as a new light chain (LC-3) of microtubule-associated protein 1 (MAP-1)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25654548
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1172/JCI73940
1 reference
stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
PMCID
4382236
1 reference
stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
PubMed ID
25654548
1 reference
stated in
Europe PubMed Central
PubMed ID
25654548
retrieved
7 August 2017
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