(Q36902253)

17 August 2017

1 reference

title

Inflammatory mediators leading to protein misfolding and uncompetitive/fast off-rate drug therapy for neurodegenerative disorders (English)

1 reference

17 August 2017

1 reference

Stuart A Lipton

1

1 reference

17 August 2017

Zezong Gu

series ordinal

2

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17 August 2017

Tomohiro Nakamura

series ordinal

3

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17 August 2017

publication date

1 January 2007

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International Review of Neurobiology

17 August 2017

published in

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17 August 2017

volume

82

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17 August 2017

page(s)

1-27

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Expanding insights of mitochondrial dysfunction in Parkinson's disease.

17 August 2017

cites work

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Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer

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7 January 2021

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

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7 January 2021

The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status

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7 January 2021

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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7 January 2021

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

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7 January 2021

Neurodegenerative diseases and oxidative stress

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7 January 2021

Experimental models of Parkinson's disease

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7 January 2021

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

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7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

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7 January 2021

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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7 January 2021

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

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7 January 2021

Nitric oxide: a physiologic messenger molecule

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7 January 2021

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

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7 January 2021

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

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7 January 2021

Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes

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7 January 2021

Nitric oxide synthases: targets for therapeutic strategies in neurological diseases

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7 January 2021

Protein-misfolding diseases and chaperone-based therapeutic approaches

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7 January 2021

The chemical biology of clinically tolerated NMDA receptor antagonists

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7 January 2021

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

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7 January 2021

Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

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7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

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7 January 2021

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

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7 January 2021

Calcium-dependent release of NO from intracellular S-nitrosothiols

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Opposing activities protect against age-onset proteotoxicity

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The biochemistry of Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Chaperones increase association of tau protein with microtubules

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant. Insights into the molecular basis for dimer stability

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The human protein disulphide isomerase family: substrate interactions and functional properties

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Setting the standards: quality control in the secretory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Neurodegenerative diseases and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Nitrosative stress in the ER: a new role for S-nitrosylation in neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Ubiquitin, proteasomes, and the aging brain

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Protein disulfide isomerase: the structure of oxidative folding

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Nitrosative and oxidative stress links dysfunctional ubiquitination to Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons.

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

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7 January 2021

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Role of nitric oxide in rotenone-induced nigro-striatal injury

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Protein S-nitrosylation: purview and parameters

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Nitroxyl disulfides, novel intermediates in transnitrosation reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Protein aggregation after transient cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Are adult learning mechanisms also used for development?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

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7 January 2021

Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

NMDA-dependent superoxide production and neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Dopamine covalently modifies and functionally inactivates parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The ubiquitin pathway in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

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7 January 2021

NMDA receptors, glial cells, and clinical medicine

1 reference

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7 January 2021

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Comment on "S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function".

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Fas-induced caspase denitrosylation

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Comparative genomics of the RBR family, including the Parkinson's disease-related gene parkin and the genes of the ariadne subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

S-nitrosylation regulates apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Tripartite management of unfolded proteins in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Modulation of neurodegeneration by molecular chaperones

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Molecular mechanisms of nitrosative stress-mediated protein misfolding in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

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https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Cellular environment facilitates protein accumulation in aged rat hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

S-nitrosothiol depletion in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Locally distributed synaptic potentiation in the hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The unfolded protein response: an intracellular signalling pathway with many surprising features

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Characterization of the S-denitrosation activity of protein disulfide isomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Redox signaling: nitrosylation and related target interactions of nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Oxidative modifications in nitrosative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Blood Flow Regulation by S-Nitrosohemoglobin in the Physiological Oxygen Gradient

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Nitrosylation. the prototypic redox-based signaling mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Mediators of endoplasmic reticulum stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Suppression of neuronal apoptosis by S-nitrosylation of caspases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Site-directed mutagenesis of human protein disulphide isomerase: effect on the assembly, activity and endoplasmic reticulum retention of human prolyl 4-hydroxylase in Spodoptera frugiperda insect cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

The unfolded protein response: a stress signaling pathway critical for health and disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982001-0

7 January 2021

10.1016/S0074-7742(07)82001-0

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DOI

1 reference

17 August 2017

1 reference