(Q36984373)

17 August 2017

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins (English)

1 reference

Erratum: Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.

17 August 2017

0 references

1 reference

corrigendum / erratum

0 references

Benjamin H Durham

7

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Heidi Dvinge

Heidi Dvinge

2

0 references

Andrei Krivtsov

Andrei Krivtsov

16

0 references

Chun-Wei Chen

Chun-Wei Chen

12

0 references

Eunhee Kim

Eunhee Kim

3

0 references

Camille Lobry

Camille Lobry

11

0 references

Akihide Yoshimi

Akihide Yoshimi

8

0 references

Robert K. Bradley

Robert K Bradley

21

0 references

Young Rock Chung

6

Young Rock Chung

1 reference

17 August 2017

22

Omar Abdel-Wahab

1 reference

17 August 2017

5

Jean-Baptiste Micol

1 reference

17 August 2017

1

Stanley Chun-Wei Lee

1 reference

17 August 2017

18

James Palacino

1 reference

17 August 2017

19

Silvia Buonamici

1 reference

17 August 2017

Hana Cho

4

1 reference

17 August 2017

Young Joon Kim

9

1 reference

17 August 2017

Michael Thomas

10

1 reference

17 August 2017

Alessandro Pastore

13

1 reference

17 August 2017

Justin Taylor

14

1 reference

17 August 2017

Xujun Wang

15

1 reference

17 August 2017

Scott A Armstrong

17

1 reference

17 August 2017

Peter G Smith

20

1 reference

17 August 2017

language of work or name

English

0 references

publication date

2 May 2016

1 reference

17 August 2017

1 reference

17 August 2017

22

1 reference

17 August 2017

6

1 reference

17 August 2017

672-678

1 reference

https://scigraph.springernature.com/pub.10.1038/nm.4097

17 August 2017

0 references

cites work

Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Quantitative visualization of alternative exon expression from RNA-seq data

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Clinical and biological implications of driver mutations in myelodysplastic syndromes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Phase I pharmacokinetic and pharmacodynamic study of the first-in-class spliceosome inhibitor E7107 in patients with advanced solid tumors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

The UCSC Genome Browser database: extensions and updates 2013.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

The spliceosome as a target of novel antitumour drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

BioMart Central Portal: an open database network for the biological community

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Frequent pathway mutations of splicing machinery in myelodysplasia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Analysis and design of RNA sequencing experiments for identifying isoform regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

A scaling normalization method for differential expression analysis of RNA-seq data

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Gene ontology analysis for RNA-seq: accounting for selection bias

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

TopHat: discovering splice junctions with RNA-Seq

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

SC35 plays a role in T cell development and alternative splicing of CD45.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

U2AF1 mutations alter splice site recognition in hematological malignancies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Mutations and prognosis in primary myelofibrosis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Bayesian hypothesis testing for psychologists: a tutorial on the Savage-Dickey method.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

VavCre transgenic mice: a tool for mutagenesis in hematopoietic and endothelial lineages.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899191

Clonal hematopoiesis and blood-cancer risk.

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.4097

Crystal structure of a Pumilio homology domain

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.4097

21 January 2018

Identifiers

DOI

10.1038/NM.4097

1 reference

17 August 2017

1 reference

17 August 2017

PubMed publication ID

27135740

1 reference