(Q37027500)

17 August 2017

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title

Ubiquitin-proteasome system dysfunction in Parkinson's disease: current evidence and controversies (English)

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ubiquitin-proteasome system

17 August 2017

main subject

0 references

1 reference

Kah-Leong Lim

1

1 reference

17 August 2017

language of work or name

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1 December 2007

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Expert Review of Proteomics

17 August 2017

published in

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17 August 2017

volume

4

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17 August 2017

issue

6

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17 August 2017

page(s)

769-781

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Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

17 August 2017

cites work

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Ubiquitin-mediated proteolysis: biological regulation via destruction

21 January 2018

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21 January 2018

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Mechanisms underlying ubiquitination

21 January 2018

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A proteomics approach to understanding protein ubiquitination

21 January 2018

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21 January 2018

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Proteasome-independent functions of ubiquitin in endocytosis and signaling

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Multicatalytic proteinase is present in Lewy bodies and neurofibrillary tangles in diffuse Lewy body disease brains

21 January 2018

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Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study

21 January 2018

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Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

The ubiquitin pathway in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Proteasome dysfunction in aged human alpha-synuclein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Proteasomal function is impaired in substantia nigra in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Proteasomal activity in brain differs between species and brain regions and changes with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Proteasome inhibition and aggregation in Parkinson's disease: a comparative study in untransfected and transfected cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Cytotoxic and genotoxic potential of dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Dopamine covalently modifies and functionally inactivates parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

RING finger 1 mutations in Parkin produce altered localization of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

SEPT5_v2 is a parkin-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Identification of far upstream element-binding protein-1 as an authentic Parkin substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Glutathione decreases in dopaminergic PC12 cells interfere with the ubiquitin protein degradation pathway: relevance for Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Deadly encounter: ubiquitin meets apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Transcriptional regulation by p53: one protein, many possibilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Proteasome inhibitor lactacystin disturbs the intracellular calcium homeostasis of dopamine neurons in ventral mesencephalic cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Role of calcium in neuronal cell injury: which subcellular compartment is involved?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Retrograde dopaminergic neuron degeneration following intrastriatal proteasome inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Proteasome inhibition and Parkinson's disease modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Reproducible nigral cell loss after systemic proteasomal inhibitor administration to rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

The proteasomal inhibition model of Parkinson's disease: "Boon or bust"?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Decreased proteasome activity is associated with increased severity of liver pathology and oxidative stress in experimental alcoholic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin-deficient mice are not a robust model of parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Loss of locus coeruleus neurons and reduced startle in parkin null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin affects mitochondrial function and apoptosis in neuronal and myogenic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

The neurological mutant quaking(viable) is Parkin deficient

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Aggresomes, inclusion bodies and protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Autophagy in neurons: it is not all about food

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Autophagy in cell death: an innocent convict?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

New genetic insights into Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.769

21 January 2018

Identifiers

DOI

10.1586/14789450.4.6.769

1 reference

17 August 2017

1 reference