(Q37201545)

18 August 2017

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title

Approaches for applications of physiologically based pharmacokinetic models in risk assessment (English)

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18 August 2017

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Chad M Thompson

1

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18 August 2017

Babasaheb Sonawane

2

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18 August 2017

Hugh A Barton

3

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18 August 2017

Robert S DeWoskin

4

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18 August 2017

John C Lipscomb

5

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18 August 2017

Paul Schlosser

6

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18 August 2017

Weihsueh A Chiu

7

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18 August 2017

Kannan Krishnan

8

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18 August 2017

publication date

1 August 2008

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Journal of Toxicology and Environmental Health Part B: Critical Reviews

18 August 2017

published in

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18 August 2017

volume

11

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18 August 2017

issue

7

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18 August 2017

page(s)

519-547

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Metabolic scaling: consensus or controversy?

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Development of physiologically based pharmacokinetic and physiologically based pharmacodynamic models for applications in toxicology and risk assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Mode of action and tissue dosimetry in current and future risk assessments

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologically based pharmacokinetic (PBPK) models for nasal tissue dosimetry of organic esters: assessing the state-of-knowledge and risk assessment applications with methyl methacrylate and vinyl acetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Nasal tissue dosimetry-issues and approaches for "Category 1" gases: a report on a meeting held in Research Triangle Park, NC, February 11-12, 1998.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A two-stage theory of carcinogenesis in relation to the age distribution of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Mode-of-action-based dosimeters for interspecies extrapolation of vinyl acetate inhalation risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologically-based kinetic modeling of vapours toxic to the respiratory tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A biologically based dynamic model for predicting the disposition of methanol and its metabolites in animals and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiological parameter values for physiologically based pharmacokinetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

The Acute Exposure Guideline Level (AEGL) program: applications of physiologically based pharmacokinetic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A CFD-PBPK hybrid model for simulating gas and vapor uptake in the rat nose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Concentration-time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

DNA-protein cross-links (DPX) and cell proliferation in B6C3F1 mice but not Syrian golden hamsters exposed to dichloromethane: pharmacokinetics and risk assessment with DPX as dosimeter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Armitage-Doll two-stage model: implications and extension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Evaluation of physiologically based pharmacokinetic models for use in risk assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Pharmacokinetics of 2-methoxyethanol and 2-methoxyacetic acid in the pregnant mouse: a physiologically based mathematical model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Risk assessment extrapolations and physiological modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Incorporation of pharmacokinetics in noncancer risk assessment: example with chloropentafluorobenzene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Associations between mortality and air pollution in central Europe

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Review and evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Cell proliferation in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Hepatic Foci in Rats after Diethylnitrosamine Initiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotion: Evaluation of a Quantitative Two-Cell Model and of CYP 1A1/1A2 as a Dosimeter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Computer simulation of cell growth governed by stochastic processes: application to clonal growth cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Evaluation of Physiologically Based Models of Pregnancy and Lactation for Their Application in Children's Health Risk Assessments

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Styrene respiratory tract toxicity and mouse lung tumors are mediated by CYP2F-generated metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A physiological toxicokinetic model for 1,3-butadiene in rodents and man: blood concentrations of 1,3-butadiene, its metabolically formed epoxides, and of haemoglobin adducts--relevance of glutathione depletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Effects of glutathione transferase theta polymorphism on the risk estimates of dichloromethane to humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Evaluating the risk of liver cancer in humans exposed to trichloroethylene using physiological models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Application of a physiologically based pharmacokinetic model for isopropanol in the derivation of a reference dose and reference concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Characterization of age-related changes in body weight and organ weights from birth to adolescence in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Mass transport analysis: inhalation rfc methods framework for interspecies dosimetric adjustment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A review of the applications of physiologically based pharmacokinetic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in pregnant Long Evans rats: association of measured tissue concentrations with developmental effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

The application of dosimetry models to identify key processes and parameters for default dose-response assessment approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Mechanistic insights aid the search for CFC substitutes: risk assessment of HCFC-123 as an example

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A Bayesian analysis of the influence of GSTT1 polymorphism on the cancer risk estimate for dichloromethane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Differences in rates of benzene metabolism correlate with observed genotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Impact of physiologically based pharmacokinetic modeling on benchmark dose calculations for TCDD-induced biochemical responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Improving cancer dose-response characterization by using physiologically based pharmacokinetic modeling: an analysis of pooled data for acrylonitrile-induced brain tumors to assess cancer potency in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A physiological model for ligand-induced accumulation of alpha 2u globulin in male rat kidney: roles of protein synthesis and lysosomal degradation in the renal dosimetry of 2,4,4-trimethyl-2-pentanol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A physiologically based description of ethylene oxide dosimetry in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologically based pharmacokinetic model for acetone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A biologically-based dose-response model for developmental toxicology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Development and utilization of physiologically based pharmacokinetic models for toxicological applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Use of physiologically based pharmacokinetic models to establish biological exposure indexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Cancer risk assessment for dioxane based upon a physiologically-based pharmacokinetic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Cancer risk associated with household exposure to chloroform

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Application of biologically based computer modeling to simple or complex mixtures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

In vitro to in vivo extrapolation for trichloroethylene metabolism in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: the first steps

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Effects of polychlorinated biphenyls in rat liver: quantitative analysis of enzyme-altered foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Analysis of solvent central nervous system toxicity and ethanol interactions using a human population physiologically based kinetic and dynamic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Three-dimensional computer modeling of the human upper respiratory tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Chloroform: exposure estimation, hazard characterization, and exposure-response analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Dose-response analyses of experimental cancer data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Haber's rule: a special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Drug toxicokinetics: scope and limitations that arise from species differences in pharmacodynamic and carcinogenic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Mutation and cancer: a model for human carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Two-event model for carcinogenesis: biological, mathematical, and statistical considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: a case study with toluene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Dosimetry modeling of highly soluble reactive gases in the respiratory tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Implementation of EPA Revised Cancer Assessment Guidelines: Incorporation of Mechanistic and Pharmacokinetic Data.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Issues of dosimetry in inhalation toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

The practice of exposure assessment: a state-of-the-art review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Biological monitoring of controlled toluene exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Mode of action and pharmacokinetic studies of 2-butoxyethanol in the mouse with an emphasis on forestomach dosimetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A mechanistic algorithm for predicting blood:air partition coefficients of organic chemicals with the consideration of reversible binding in hemoglobin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A tissue composition-based algorithm for predicting tissue:air partition coefficients of organic chemicals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Variability of safe dose estimates when using complicated models of the carcinogenic process. A case study: methylene chloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiological modeling of age-specific changes in the pharmacokinetics of organic chemicals in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A physiologically-based pharmacokinetic model assessment of methyl t-butyl ether in groundwater for a bathing and showering determination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologically Based Pharmacokinetic Modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologically based pharmacokinetic modeling with methylchloroform: implications for interspecies, high dose/low dose, and dose route extrapolations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene chloride: implications for risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

In vitro metabolism of methylene chloride in human and animal tissues: use in physiologically based pharmacokinetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Development of a physiologically based pharmacokinetic model for risk assessment with 1,4-dioxane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Predicting Cancer Risk from Vinyl Chloride Exposure with a Physiologically Based Pharmacokinetic Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A physiologically based model for gastrointestinal absorption and excretion of chemicals carried by lipids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologic pharmacokinetic models and interanimal species scaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A distributed parameter physiologically-based pharmacokinetic model for dermal and inhalation exposure to volatile organic compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A pharmacodynamic analysis of TCDD-induced cytochrome P450 gene expression in multiple tissues: dose- and time-dependent effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Benchmark dose risk assessment for formaldehyde using airflow modeling and a single-compartment, DNA-protein cross-link dosimetry model to estimate human equivalent doses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Dose-dependent transitions in mechanisms of toxicity: case studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A proposed inhalation reference concentration for methanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A mathematical model of canine granulocytopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Biologically motivated computational modeling of chloroform cytolethality and regenerative cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Use of a physiologically based pharmacokinetic model to identify exposures consistent with human biomonitoring data for chloroform

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Incorporating Monte Carlo simulation into physiologically based pharmacokinetic models using advanced continuous simulation language (ACSL): a computational method.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Noninvasive biomonitoring approaches to determine dosimetry and risk following acute chemical exposure: analysis of lead or organophosphate insecticide in saliva

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Development of an integrated microanalytical system for analysis of lead in saliva and linkage to a physiologically based pharmacokinetic model describing lead saliva secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Mathematical modeling of the retention and clearance of low-toxicity particles in the lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Application of physiologically based toxicokinetic modelling to study the impact of the exposure scenario on the toxicokinetics and the behavioural effects of toluene in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Extrapolation of animal toxicity to humans: interspecies comparisons in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

History of pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

Physiologically based pharmacokinetic models applicable to organogenesis: extrapolation between species and potential use in prenatal toxicity risk assessments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

BIOLOGICALLY BASED DOSE-RESPONSE MODELS FOR DEVELOPMENTAL TOXICANTS: Lessons from Methylmercury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937400701724337

10.1080/10937400701724337

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference