(Q37224598)

19 August 2017

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title

The Pak1 kinase: an important regulator of neuronal morphology and function in the developing forebrain (English)

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19 August 2017

Margareta Nikolić

1

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19 August 2017

publication date

1 April 2008

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19 August 2017

published in

Molecular Neurobiology

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19 August 2017

volume

37

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19 August 2017

issue

2-3

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19 August 2017

page(s)

187-202

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https://scigraph.springernature.com/pub.10.1007/s12035-008-8032-1

19 August 2017

exact match

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cites work

Regulation of Spine Morphology and Synaptic Function by LIMK and the Actin Cytoskeleton

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12035-008-8032-1

Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease

21 January 2018

1 reference

12 December 2020

Pathological tau tangles localize to focal cortical dysplasia in older patients.

1 reference

12 December 2020

Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes

1 reference

12 December 2020

Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice

1 reference

12 December 2020

The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

1 reference

12 December 2020

p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling

1 reference

12 December 2020

PAK promotes morphological changes by acting upstream of Rac.

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12 December 2020

Akt Phosphorylation of Serine 21 on Pak1 Modulates Nck Binding and Cell Migration

1 reference

12 December 2020

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

1 reference

12 December 2020

Altered synaptic function in Alzheimer's disease

1 reference

12 December 2020

Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion

1 reference

12 December 2020

Alsin and the molecular pathways of amyotrophic lateral sclerosis

1 reference

12 December 2020

Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons

1 reference

12 December 2020

PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae

1 reference

12 December 2020

Synaptic dysfunction and disruption of postsynaptic drebrin-actin complex: a study of neurological disorders accompanied by cognitive deficits.

1 reference

12 December 2020

The cell biology of neurogenesis

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12 December 2020

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

1 reference

12 December 2020

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

1 reference

12 December 2020

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12 December 2020

Mechanism of polarized protrusion formation on neuronal precursors migrating in the developing chicken cerebellum

1 reference

12 December 2020

Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling--a hypothesis on neuronal migration

1 reference

12 December 2020

Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1

1 reference

12 December 2020

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

1 reference

12 December 2020

PAK3 mutation in nonsyndromic X-linked mental retardation

1 reference

12 December 2020

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12 December 2020

Gbetagamma subunits stimulate p21-activated kinase 1 (PAK1) through activation of PI3-kinase and Akt but act independently of Rac1/Cdc42.

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12 December 2020

Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1.

1 reference

12 December 2020

p21-Activated kinase-1 is necessary for depolarization-mediated neuronal survival.

1 reference

12 December 2020

Temporal and spatial distribution of activated Pak1 in fibroblasts

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12 December 2020

Factors critical for the plasticity of dendritic spines and memory storage.

1 reference

12 December 2020

CRIPak, a novel endogenous Pak1 inhibitor

1 reference

12 December 2020

Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin

1 reference

12 December 2020

Differential distribution of alpha and beta isoforms of p21-activated kinase in the monkey cerebral neocortex and hippocampus.

1 reference

12 December 2020

The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration

1 reference

12 December 2020

Lim kinase regulates the development of olfactory and neuromuscular synapses

1 reference

12 December 2020

Lim kinases, regulators of actin dynamics

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12 December 2020

Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology

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12 December 2020

Abnormal development of dendritic spines in FMR1 knock-out mice

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12 December 2020

Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus.

1 reference

12 December 2020

Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.

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12 December 2020

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1 reference

12 December 2020

On dendrites in Down syndrome and DS murine models: a spiny way to learn.

1 reference

12 December 2020

The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface

1 reference

12 December 2020

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

1 reference

12 December 2020

Dlx transcription factors promote migration through repression of axon and dendrite growth

1 reference

12 December 2020

DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system

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12 December 2020

Synapse formation is regulated by the signaling adaptor GIT1

1 reference

12 December 2020

Pak1 regulates dendritic branching and spine formation

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12 December 2020

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

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12 December 2020

PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans

1 reference

12 December 2020

Neuronal polarity: from extracellular signals to intracellular mechanisms

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12 December 2020

p21-activated kinases in cancer

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12 December 2020

Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

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12 December 2020

Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila

1 reference

12 December 2020

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

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12 December 2020

The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus

1 reference

12 December 2020

PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development

1 reference

12 December 2020

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.

1 reference

12 December 2020

GIT1 activates p21-activated kinase through a mechanism independent of p21 binding

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12 December 2020

Targeted disruption of the gene for the PAK5 kinase in mice

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12 December 2020

Progenitor cell maintenance requires numb and numblike during mouse neurogenesis

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12 December 2020

Molecular and cellular mechanisms of dendritic morphogenesis

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12 December 2020

cGMP-dependent protein kinase phosphorylates p21-activated kinase (Pak) 1, inhibiting Pak/Nck binding and stimulating Pak/vasodilator-stimulated phosphoprotein association

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12 December 2020

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

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12 December 2020

Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration

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12 December 2020

Big roles for small GTPases in the control of directed cell movement

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12 December 2020

Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation

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12 December 2020

The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10.

1 reference

12 December 2020

A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC

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12 December 2020

Control of tangential/non-radial migration of neurons in the developing cerebral cortex

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12 December 2020

Cell cycle-regulated phosphorylation of p21-activated kinase 1.

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12 December 2020

Biology of the p21-activated kinases

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12 December 2020

Regulation of leading edge microtubule and actin dynamics downstream of Rac1

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12 December 2020

Cortical interneurons and their origins

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12 December 2020

Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.

1 reference

12 December 2020

Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis

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12 December 2020

Mechanisms of synapse assembly and disassembly

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12 December 2020

Dictyostelium PAKc is required for proper chemotaxis

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12 December 2020

Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

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12 December 2020

Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks

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12 December 2020

The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia

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12 December 2020

Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation

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12 December 2020

The establishment of polarity by hippocampal neurons in culture

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12 December 2020

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

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12 December 2020

Localized activation of p21-activated kinase controls neuronal polarity and morphology

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12 December 2020

The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

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12 December 2020

Spindle regulation in neural precursors of flies and mammals

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12 December 2020

Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin

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12 December 2020

The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42

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12 December 2020

Regulation of cerebral cortical size by control of cell cycle exit in neural precursors

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12 December 2020

Diverse roles of Rho family GTPases in neuronal development, survival, and death

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12 December 2020

Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

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12 December 2020

Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma

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12 December 2020

Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons.

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12 December 2020

A hippocampal Cdk5 pathway regulates extinction of contextual fear

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12 December 2020

Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3.

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12 December 2020

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity

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12 December 2020

Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes

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12 December 2020

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

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12 December 2020

ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth

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12 December 2020

DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3

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12 December 2020

Pak1 and its T212 phosphorylated form accumulate in neurones and epithelial cells of the developing rodent

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12 December 2020

PAK-in' up cGMP for the move

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12 December 2020

Identification of phosphorylation sites in betaPIX and PAK1

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12 December 2020

Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis

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12 December 2020

Spine architecture and synaptic plasticity

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12 December 2020

Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.

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12 December 2020

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases

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12 December 2020

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

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12 December 2020

Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases

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12 December 2020

Phosphoinositide 3-kinase-dependent activation of Rac.

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12 December 2020

Regulation of dendritic spine motility and stability by Rac1 and Rho kinase: evidence for two forms of spine motility

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12 December 2020

p21-activated kinases: three more join the Pak.

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12 December 2020

Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice

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12 December 2020

Molecular diversity of Dscam: recognition of molecular identity in neuronal wiring

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12 December 2020

Central nervous system functions of PAK protein family: from spine morphogenesis to mental retardation

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12 December 2020

Slit Stimulation Recruits Dock and Pak to the Roundabout Receptor and Increases Rac Activity to Regulate Axon Repulsion at the CNS Midline

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12 December 2020

Distinct cellular effects and interactions of the Rho-family GTPase TC10.

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12 December 2020

Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and Rho

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12 December 2020

Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

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12 December 2020

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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12 December 2020

10.1007/S12035-008-8032-1

Identifiers

DOI

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19 August 2017

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