(Q37588591)

21 August 2017

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title

E3 ubiquitin ligases in T-cell tolerance (English)

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21 August 2017

Josef M Penninger

2

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Magdalena Paolino

series ordinal

1

object named as

Magdalena Paolino

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21 August 2017

language of work or name

English

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publication date

1 September 2009

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European Journal of Immunology

21 August 2017

published in

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21 August 2017

volume

39

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21 August 2017

issue

9

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21 August 2017

page(s)

2337-2344

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Cellular and genetic mechanisms of self tolerance and autoimmunity

21 August 2017

cites work

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https://api.crossref.org/works/10.1002%2FEJI.200939662

A central role for central tolerance

21 January 2018

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The enemy within: keeping self-reactive T cells at bay in the periphery

21 January 2018

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E3 ligases in T cell anergy--turning immune responses into tolerance

21 January 2018

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E3 ubiquitin ligases as T cell anergy factors.

21 January 2018

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Ubiquitin ligases and the immune response

21 January 2018

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Mechanisms underlying ubiquitination

21 January 2018

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Themes and variations on ubiquitylation

21 January 2018

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Immunity by ubiquitylation: a reversible process of modification

21 January 2018

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Ubiquitylation in innate and adaptive immunity.

21 January 2018

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21 January 2018

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Transcriptional mechanisms underlying lymphocyte tolerance.

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.200939662

Calcium signalling in lymphocyte activation and disease

21 January 2018

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Calcium signaling in lymphocytes

21 January 2018

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Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

21 January 2018

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NFAT proteins: key regulators of T-cell development and function

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.200939662

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.200939662

Partners in transcription: NFAT and AP-1.

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.200939662

NFAT transcription factors in control of peripheral T cell tolerance.

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.200939662

FOXP3 controls regulatory T cell function through cooperation with NFAT

21 January 2018

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NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.200939662

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.200939662

The sound of silence: modulating anergy in T lymphocytes.

21 January 2018

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Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3.

21 January 2018

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https://api.crossref.org/works/10.1002%2FEJI.200939662

Egr-2 and Egr-3 are negative regulators of T cell activation.

21 January 2018

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Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection

21 January 2018

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Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance

21 January 2018

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Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

The molecular signature of CD8+ T cells undergoing deletional tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Follicular helper T cells are required for systemic autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Oxidized phospholipids induce anergy in human peripheral blood T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Molecular mechanisms for adaptive tolerance and other T cell anergy models

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4+ T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Deubiquitylation and regulation of the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Two isoforms of otubain 1 regulate T cell anergy via GRAIL

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Differential Control of CD28-Regulated In Vivo Immunity by the E3 Ligase Cbl-b

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

TCR affinity and negative regulation limit autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

7 January 2021

Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

7 January 2021

Cutting Edge: Regulation of T Cell Activation Threshold by CD28 Costimulation Through Targeting Cbl-b for Ubiquitination

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

7 January 2021

Cutting edge: requirement for TRAF6 in the induction of T cell anergy

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

7 January 2021

TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200939662

7 January 2021

Identifiers

DOI

10.1002/EJI.200939662

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21 August 2017

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