(Q37191002)

18 August 2017

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title

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer (English)

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18 August 2017

M Rossi

6

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Aaron Ciechanover

11

object named as

A Ciechanover

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18 August 2017

G Melino

1

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18 August 2017

E Gallagher

2

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18 August 2017

R I Aqeilan

3

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18 August 2017

R Knight

4

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18 August 2017

A Peschiaroli

5

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18 August 2017

F Scialpi

7

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18 August 2017

M Malatesta

8

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18 August 2017

L Zocchi

9

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18 August 2017

G Browne

10

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18 August 2017

F Bernassola

12

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18 August 2017

publication date

1 July 2008

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Cell Death & Differentiation

18 August 2017

published in

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18 August 2017

volume

15

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18 August 2017

issue

7

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18 August 2017

page(s)

1103-1112

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https://scigraph.springernature.com/pub.10.1038/cdd.2008.60

18 August 2017

exact match

0 references

cites work

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

E3 ubiquitin ligases as T cell anergy factors.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Notch signalling during peripheral T-cell activation and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The thymus and T-cell commitment: the right niche for Notch?

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Itch genetically interacts with Notch1 in a mouse autoimmune disease model

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

TGFbeta signalling in control of T-cell-mediated self-reactivity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

p73: Friend or foe in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Functional regulation of p73 and p63: development and cancer

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Chemosensitivity linked to p73 function

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The ubiquitin-protein ligase Itch regulates p73 stability

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The E3 ubiquitin ligase Itch controls the protein stability of p63

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Itch inhibition regulates chemosensitivity in vitro

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Role for the p53 homologue p73 in E2F-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Differential ability of T cell subsets to undergo activation-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The cornified envelope: a model of cell death in the skin

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Canonical notch signaling functions as a commitment switch in the epidermal lineage

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Defective T Cell Differentiation in the Absence of Jnk1

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.60

7 January 2021

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1038/CDD.2008.60

Identifiers

DOI

10.1038/CDD.2008.60

1 reference

18 August 2017

1 reference