(Q37619695)

English

Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.

scientific article published on 31 May 2016

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3 April 2020

Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers (English)

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3 April 2020

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based on heuristic

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based on heuristic

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based on heuristic

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Elisabet Cuyàs

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3 April 2020

Salvador Fernández-Arroyo

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Javier A Menendez

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3 April 2020

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Ruth Lupu

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Jorge Joven

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1 August 2016

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3 April 2020

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52974-52992

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3 April 2020

Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome

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Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin

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Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.

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Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction

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Metformin inhibits tumor growth by regulating multiple miRNAs in human cholangiocarcinoma

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Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer.

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BRCA1 haploinsufficiency for replication stress suppression in primary cells

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Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

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Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of aging and cancer

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BRCA1 induces major energetic metabolism reprogramming in breast cancer cells.

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The complex role of branched chain amino acids in diabetes and cancer

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BRCA1 haploinsufficiency leads to altered expression of genes involved in cellular proliferation and development

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Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

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BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability

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Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis

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Mammosphere formation in breast carcinoma cell lines depends upon expression of E-cadherin

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Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin

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Breast cancer 1 (BrCa1) may be behind decreased lipogenesis in adipose tissue from obese subjects

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Evolutionary pathways in BRCA1-associated breast tumors

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Metformin: multi-faceted protection against cancer

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BRCA1 and BRCA2: different roles in a common pathway of genome protection

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Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

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Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway.

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

Oncogenic AKTivation of translation as a therapeutic target

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

6 September 2017

BRCA1 haploinsufficiency, but not heterozygosity for a BRCA1-truncating mutation, deregulates homologous recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

14 September 2017

Oncobiguanides: Paracelsus' law and nonconventional routes for administering diabetobiguanides for cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

28 September 2017

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

25 June 2018

Chronic activation of mTOR complex 1 by branched chain amino acids and organ hypertrophy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

1 September 2018

Chromosomal instability causes sensitivity to metabolic stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

1 September 2018

Metformin directly acts on mitochondria to alter cellular bioenergetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

1 September 2018

Glutaminolysis activates Rag-mTORC1 signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

1 September 2018

BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

1 September 2018

Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

1 September 2018

Increased progesterone receptor expression in benign epithelium of BRCA1-related breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

1 September 2018

Exercise and healty weight in youth delay onset of breast cancer in women at highest risk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5288162

1 September 2018

Genomic alterations in histopathologically normal breast tissue from BRCA1 mutation carriers may be caused by BRCA1 haploinsufficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/27259235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Getting to the root of BRCA1-deficient breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27259235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.9732

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27259235%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27259235%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27259235%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

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