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Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites.
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Europe PubMed Central
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3979906
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24526120%20AND%20SRC:MED&resulttype=core&format=json
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7 March 2020
title
Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites
(English)
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Europe PubMed Central
PMC publication ID
3979906
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7 March 2020
author
Javier A Menendez
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1
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Europe PubMed Central
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3979906
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7 March 2020
Tomas Alarcon
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2
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Europe PubMed Central
PMC publication ID
3979906
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24526120%20AND%20SRC:MED&resulttype=core&format=json
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7 March 2020
Jorge Joven
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3
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Europe PubMed Central
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7 March 2020
author name string
Javier A Menendez
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1
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Europe PubMed Central
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3979906
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5 September 2017
Tomás Alarcón
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2
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Europe PubMed Central
PMC publication ID
3979906
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5 September 2017
Jorge Joven
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3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3979906
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5 September 2017
publication date
3 February 2014
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Europe PubMed Central
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3979906
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retrieved
7 March 2020
published in
Cell Cycle
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stated in
Europe PubMed Central
PMC publication ID
3979906
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24526120%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 March 2020
volume
13
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Europe PubMed Central
PMC publication ID
3979906
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7 March 2020
issue
5
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Europe PubMed Central
PMC publication ID
3979906
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retrieved
7 March 2020
page(s)
699-709
1 reference
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Europe PubMed Central
PMC publication ID
3979906
reference URL
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7 March 2020
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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
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SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model
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6 September 2017
High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia
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6 September 2017
Somatic mitochondrial DNA mutations in mammalian aging
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6 September 2017
MYC as a regulator of ribosome biogenesis and protein synthesis
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6 September 2017
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
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6 September 2017
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
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6 September 2017
The ups and downs of Myc biology
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
The Warburg effect is genetically determined in inherited pheochromocytomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
The VHL tumor suppressor: master regulator of HIF
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Facilitating replication under stress: an oncogenic function of MYC?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Understanding the Warburg effect: the metabolic requirements of cell proliferation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Tumor suppressors and cell metabolism: a recipe for cancer growth
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Subcellular dynamics of the VHL tumor suppressor: on the move for HIF degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Prolyl hydroxylases as regulators of cell metabolism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Reflecting on 25 years with MYC.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Modelling Myc inhibition as a cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Tumor cell metabolism: cancer's Achilles' heel
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Unsupervised clustering of gene expression data points at hypoxia as possible trigger for metabolic syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Hypoxia-induced energy stress regulates mRNA translation and cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
c-MYC: more than just a matter of life and death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Myc-Is this the oncogene from Hell?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
6 September 2017
Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
14 September 2017
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
14 September 2017
Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
14 September 2017
Omomyc expression in skin prevents Myc-induced papillomatosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
14 September 2017
Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
25 September 2017
Omomyc, a potential Myc dominant negative, enhances Myc-induced apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
25 September 2017
Hyperglycemic pseudohypoxia and diabetic complications.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
25 September 2017
The Warburg effect version 2.0: metabolic reprogramming of cancer stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
23 June 2018
The emerging role of fumarate as an oncometabolite
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
23 June 2018
c-MYC and SIRT1 locked in a vicious cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
23 June 2018
Metabolic targets for cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
Transplantation of induced pluripotent stem cells without C-Myc attenuates retinal ischemia and reperfusion injury in rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
SDH mutations establish a hypermethylator phenotype in paraganglioma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
Exploiting the mTOR paradox for disease prevention
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
The purpose of the HIF-1/PHD feedback loop: to limit mTOR-induced HIF-1α.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
The interplay between MYC and HIF in cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
Analysis of genomic targets reveals complex functions of MYC.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979906
retrieved
31 August 2018
Use of oral antidiabetic drugs (metformin and pioglitazone) in diabetic patients with breast cancer: how does it effect serum Hif-1 alpha and 8Ohdg levels?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24526120
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.4161/CC.28079
1 reference
stated in
Europe PubMed Central
PMC publication ID
3979906
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24526120%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 March 2020
PMC publication ID
3979906
1 reference
stated in
Europe PubMed Central
PMC publication ID
3979906
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24526120%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 March 2020
PubMed publication ID
24526120
1 reference
stated in
Europe PubMed Central
PMC publication ID
3979906
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24526120%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 March 2020
ResearchGate publication ID
260195977
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