(Q37786022)

23 August 2017

title

Drugs targeting Bcl-2 family members as an emerging strategy in cancer (English)

1 reference

23 August 2017

Justin Kale

3

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David William Andrews

object named as

David W Andrews

series ordinal

4

0 references

author name string

Brian Leber

series ordinal

1

1 reference

23 August 2017

Fei Geng

series ordinal

2

1 reference

23 August 2017

publication date

8 September 2010

1 reference

Expert Reviews in Molecular Medicine

23 August 2017

published in

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23 August 2017

volume

12

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23 August 2017

page(s)

e28

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tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation

23 August 2017

cites work

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During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria

21 January 2018

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Bcl-2 changes conformation to inhibit Bax oligomerization

21 January 2018

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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

21 January 2018

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The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.

21 January 2018

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

21 January 2018

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Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.

21 January 2018

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Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

21 January 2018

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Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer

21 January 2018

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

21 January 2018

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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

21 January 2018

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Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737.

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399410001572

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

21 January 2018

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Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399410001572

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399410001572

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399410001572

Different forms of cell death induced by putative BCL2 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399410001572

Targeting the cancer kinome through polypharmacology

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399410001572

Control of mitochondrial apoptosis by the Bcl-2 family

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399410001572

A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399410001572

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Diagnosing and exploiting cancer's addiction to blocks in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Bcl-2 family on guard at the ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399410001572

Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Programmed anuclear cell death delimits platelet life span.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Bcl-XL inhibits membrane permeabilization by competing with Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399410001572

The double-edged sword of autophagy modulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Bcl-2 family members: dual regulators of apoptosis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

BAX activation is initiated at a novel interaction site

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

BH3-only proteins and their roles in programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Induction of autophagy and inhibition of tumorigenesis by beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

The role of apoptosis in cancer development and treatment response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

The landscape of somatic copy-number alteration across human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

The role of autophagy in tumour development and cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Correlation signature of the macroscopic states of the gene regulatory network in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

IRE1 signaling affects cell fate during the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Role of the unfolded protein response in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Endoplasmic reticulum stress: cell life and death decisions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Integrated endoplasmic reticulum stress responses in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Modulation of endoplasmic reticulum calcium pump by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

The autophagy effector Beclin 1: a novel BH3-only protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Essential role for Nix in autophagic maturation of erythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletion-induced apoptosis via Bax activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Oncogenic transcription factors in the human acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Genetic control of programmed cell death in the nematode C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

Why do tumors become resistant to antiangiogenesis drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

Antiapoptotic BCL-2 is required for maintenance of a model leukemia

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

Death receptors as targets for anti-cancer therapy

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

Phase II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in combination with rituximab in patients with recurrent B-cell non-Hodgkin lymphoma

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

Expanding circle of inhibition: small-molecule inhibitors of Bcl-2 as anticancer cell and antiangiogenic agents

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

A matter of life and death

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001572

7 January 2021

10.1017/S1462399410001572

Identifiers

DOI

1 reference

23 August 2017

1 reference