(Q37807468)

23 August 2017

title

Glioblastoma, cancer stem cells and hypoxia (English)

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23 August 2017

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neoplastic stem cells

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Eli E Bar

1

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23 August 2017

publication date

30 November 2010

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23 August 2017

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23 August 2017

volume

21

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23 August 2017

issue

2

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23 August 2017

page(s)

119-129

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Hypoxia helps glioma to fight therapy

23 August 2017

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Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

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Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor

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Limits of CD133 as a marker of glioma self-renewing cells.

21 January 2018

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Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue.

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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Tumour stem cells and drug resistance

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Hypoxia, HIF1 and glucose metabolism in the solid tumour

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Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.

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Hypoxia is important in the biology and aggression of human glial brain tumors.

21 January 2018

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Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding

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Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors

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Low O2 tensions and the prevention of differentiation of hES cells

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Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

21 January 2018

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Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha

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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

21 January 2018

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The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells

21 January 2018

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Making a tumour's bed: glioblastoma stem cells and the vascular niche.

21 January 2018

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Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo.

21 January 2018

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CD133 is a marker of bioenergetic stress in human glioma

21 January 2018

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Hypoxia requires notch signaling to maintain the undifferentiated cell state

21 January 2018

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The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

21 January 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Cancerous stem cells can arise from pediatric brain tumors

21 January 2018

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Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling

21 January 2018

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

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Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression

21 January 2018

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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines

21 January 2018

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Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target

21 January 2018

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Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis

21 January 2018

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Proliferation of human glioblastoma stem cells occurs independently of exogenous mitogens.

21 January 2018

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Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line

21 January 2018

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Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

21 January 2018

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Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha

21 January 2018

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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

21 January 2018

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

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LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Hypoxia-induced nucleophosmin protects cell death through inhibition of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Enumeration of neural stem and progenitor cells in the neural colony-forming cell assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Hypoxia-inducible factor-1alpha blocks differentiation of malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

The role of hypoxia-inducible factors in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Targeting hypoxia cell signaling for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Proliferative potential of vascular components in human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Glioblastoma formation from cell population depleted of Prominin1-expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Generation of germline-competent induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Getting at the root and stem of brain tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

The role of oxygen in regulating neural stem cells in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

The HIF-2α-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Hypoxia and HIF1alpha repress the differentiative effects of BMPs in high-grade glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

21 January 2018

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Targeting HIF-1 for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Identification of human brain tumour initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

The functional role of Notch signaling in human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Targeting metabolic transformation for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

A HIF-1alpha-dependent autocrine feedback loop promotes survival of serum-deprived prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Activation of p53 and its target genes p21(WAF1/Cip1) and PAG608/Wig-1 in ischemic preconditioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Angiogenesis in malignant glioma--a target for antitumor therapy?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Hypoxia in cancer: significance and impact on clinical outcome

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Characteristics of neural stem cells expanded in lowered oxygen and the potential role of hypoxia-inducible factor-1Alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

Increased HIF1α in SDH and FH deficient tumors does not cause microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00460.X

10.1111/J.1750-3639.2010.00460.X

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference