(Q37840163)

24 August 2017

1 reference

title

Targeting aneuploid cancer cells (English)

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24 August 2017

Riccardo Colombo

1

1 reference

24 August 2017

Jürgen Moll

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

12 February 2011

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Expert Opinion on Therapeutic Targets

24 August 2017

published in

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24 August 2017

volume

15

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24 August 2017

issue

5

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24 August 2017

page(s)

595-608

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Defining 'chromosomal instability'.

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Molecular classification and correlates in colorectal cancer

21 January 2018

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Telomere instability and cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Aneuploid neurons are functionally active and integrated into brain circuitry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The role of aneuploidy in promoting and suppressing tumors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Expression of oncogenic kinase Bcr-Abl impairs mitotic checkpoint and promotes aberrant divisions and resistance to microtubule-targeting agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Isolation and characterization of a pituitary tumor-transforming gene (PTTG)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The Aurora kinases: role in cell transformation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The PI3K-Akt mediates oncogenic Met-induced centrosome amplification and chromosome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Creation of human tumour cells with defined genetic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Genetic instabilities in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The aneuploidy paradox in cell growth and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

High risk of malignancy in mosaic variegated aneuploidy syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Examining the link between chromosomal instability and aneuploidy in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Aneuploidy: cancer's fatal flaw?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Effects of aneuploidy on cellular physiology and cell division in haploid yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Global up-regulation of chromosome 21 gene expression in the developing down syndrome brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Chromosomal instability determines taxane response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

A mechanism linking extra centrosomes to chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Centrosomes and cancer: how cancer cells divide with too many centrosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Oncogenes and tumour suppressors take on centrosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Chronic exposure to lead chromate causes centrosome abnormalities and aneuploidy in human lung cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Multinucleated giant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

B-Raf(V600E) signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The spindle-assembly checkpoint in space and time

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Aneuploidy acts both oncogenically and as a tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Sixteen-kinase gene expression identifies luminal breast cancers with poor prognosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Increased expression of mitotic checkpoint genes in breast cancer cells with chromosomal instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Extra centrosomes and/or chromosomes prolong mitosis in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Aneuploid colon cancer cells have a robust spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Flies without a spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The life and miracles of kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Deviant kinetochore microtubule dynamics underlie chromosomal instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Detection and correction of merotelic kinetochore orientation by Aurora B and its partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Overexpression of Separase induces aneuploidy and mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The evolutionary consequences of polyploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Efficient spontaneous fusion between some co-cultured cells, especially murine melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Stem cells, senescence, neosis and self-renewal in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Karyotypic "state" as a potential determinant for anticancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Targeting cancer cells by exploiting karyotypic complexity and chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Targeting metabolic transformation for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Identification of aneuploidy-tolerating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

How to survive aneuploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Targeting the dynamic HSP90 complex in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Synthesis and structure-activity relationship of griseofulvin analogues as inhibitors of centrosomal clustering in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Centrosome amplification can initiate tumorigenesis in flies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

A chemical tool box defines mitotic and interphase roles for Mps1 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Bub1 maintains centromeric cohesion by activation of the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Aurora kinase inhibitors: identification and preclinical validation of their biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

Genome-wide genetic analysis of polyploidy in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.558007

10.1517/14728222.2011.558007

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference