(Q37955915)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

0 references

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

author name string

L Chadwick

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

L Gentle

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

J Strachan

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

language of work or name

1 reference

1 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

Neuropathology and Applied Neurobiology

16 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

volume

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

page(s)

118-131

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

16 January 2020

cites work

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A ubiquitin ligase complex assembles linear polyubiquitin chains

21 January 2018

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Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

21 January 2018

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The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome

21 January 2018

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Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

21 January 2018

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Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

21 January 2018

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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

21 January 2018

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Diversity of polyubiquitin chains.

21 January 2018

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Ubiquitin-binding domains - from structures to functions

21 January 2018

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The regulation of proteasome degradation by multi-ubiquitin chain binding proteins

21 January 2018

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Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation

21 January 2018

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Polyubiquitin binding and disassembly by deubiquitinating enzymes

21 January 2018

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A genomic and functional inventory of deubiquitinating enzymes

21 January 2018

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Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T.

21 January 2018

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Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths

21 January 2018

1 reference

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Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53

21 January 2018

1 reference

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The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

The ubiquitin proteasome system functions as an inhibitory constraint on synaptic strengthening

21 January 2018

1 reference

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Synapse formation and plasticity: recent insights from the perspective of the ubiquitin proteasome system

21 January 2018

1 reference

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Differential regulation of proteasome activity in the nucleus and the synaptic terminals

21 January 2018

1 reference

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An essential postsynaptic role for the ubiquitin proteasome system in slow homeostatic synaptic plasticity in cultured hippocampal neurons

21 January 2018

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Ubiquitination in postsynaptic function and plasticity

21 January 2018

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Protein quality control in Alzheimer's disease by the ubiquitin proteasome system.

21 January 2018

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The ubiquitin-proteasome system in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Misframed proteins and neurodegeneration: a novel view on Alzheimer's and Parkinson's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

The role of the ubiquitin proteasome system in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Mutations in RNA: a first example of molecular misreading in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Does an inhibition of the ubiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Presenilin 1 is actively degraded by the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Molecular misreading: the occurrence of frameshift proteins in different diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Alzheimer-associated mutant ubiquitin impairs spatial reference memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Heterogeneity of ubiquitin immunoreactivity in neurofibrillary tangles of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Ubiquitin-proteasome pathway mediates degradation of APH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Degradation of nicastrin involves both proteasome and lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Proteasome inhibition and Tau proteolysis: an unexpected regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Proteasome inhibition increases tau accumulation independent of phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Analysis of alternative splicing associated with aging and neurodegeneration in the human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Molecular misreading: the frequency of dinucleotide deletions in neuronal mRNAs for beta-amyloid precursor protein and ubiquitin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Aging is not associated with proteasome impairment in UPS reporter mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Role of the ubiquitin proteasome system in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

The ubiquitin-proteasome pathway in health and disease of the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Protein homeostasis and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Structural Basis of E2-25K/UBB+1 Interaction Leading to Proteasome Inhibition and Neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Direct activation of protein kinases by unanchored polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Roles for NF-kappaB in nerve cell survival, plasticity, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

NEMO oligomerization and its ubiquitin-binding properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

"Without Ub I am nothing": NEMO as a multifunctional player in ubiquitin-mediated control of NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Direct activation of protein kinases by ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Ongoing and future developments at the Universal Protein Resource

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Animal models reveal role for tau phosphorylation in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

The role of tau phosphorylation in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Regulation of the AMPK-related protein kinases by ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Conjugation of complex polyubiquitin chains to WRNIP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

IKK mediates ischemia-induced neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

New role of IKK alpha/beta phosphorylated I kappa B alpha in axon outgrowth and axon initial segment development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-kappaB and JNK/p38 MAPK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

Working out coupled monoubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2011.01236.X

10.1111/J.1365-2990.2011.01236.X

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22082077%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference