(Q37956562)

25 August 2017

title

Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging (English)

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25 August 2017

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Donat Kögel

1

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25 August 2017

Thomas Deller

series ordinal

2

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25 August 2017

Christian Behl

series ordinal

3

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25 August 2017

publication date

16 November 2011

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25 August 2017

number of pages

9

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Experimental Brain Research

inferred from page(s)

published in

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25 August 2017

volume

217

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25 August 2017

issue

3-4

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25 August 2017

page(s)

471-479

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IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways

25 August 2017

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sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress

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The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains.

21 January 2018

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Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing

21 January 2018

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells

21 January 2018

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Alpha-secretase as a therapeutic target

21 January 2018

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Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction

21 January 2018

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Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP.

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Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

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Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

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Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

21 January 2018

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Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

21 January 2018

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Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers

21 January 2018

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Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production

21 January 2018

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Impaired calcium homeostasis in aged hippocampal neurons

21 January 2018

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Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.

21 January 2018

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Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

21 January 2018

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Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase

21 January 2018

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A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching

21 January 2018

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A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.

21 January 2018

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Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

21 January 2018

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Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer m

21 January 2018

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The unsolved relationship of brain aging and late-onset Alzheimer disease

21 January 2018

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Down-regulation of endogenous amyloid precursor protein processing due to cellular aging

21 January 2018

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Bridging physiology and pathology in AD.

21 January 2018

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The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

21 January 2018

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The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis

21 January 2018

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Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway.

21 January 2018

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Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

21 January 2018

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Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain

21 January 2018

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Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells

21 January 2018

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Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.

21 January 2018

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

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Disruption of brain cell ion homeostasis in Alzheimer's disease by oxy radicals, and signaling pathways that protect therefrom

21 January 2018

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Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway.

21 January 2018

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Neurotrophic and neuroprotective effects of hAPP in transgenic mice

21 January 2018

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Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

21 January 2018

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The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Unraveling in vivo functions of amyloid precursor protein: insights from knockout and knockdown studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Homo- and heterodimerization of APP family members promotes intercellular adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Amyloid precursor protein trafficking, processing, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Upregulation of amyloid precursor protein messenger RNA in response to traumatic brain injury: an ovine head impact model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Amyloid precursor protein modulates ERK-1 and -2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

The APP family of proteins: similarities and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Cytoprotective function of sAppalpha in human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

The amyloid precursor protein: beyond amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2932-4

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

21 January 2018

1 reference

12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

12 December 2020

Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury

1 reference

12 December 2020

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

1 reference

12 December 2020

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

1 reference

12 December 2020

The Role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins

1 reference

12 December 2020

Characterization of the neurotrophic interaction between nerve growth factor and secreted alpha-amyloid precursor protein

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12 December 2020

Signaling events regulating the neurodevelopmental triad. Glutamate and secreted forms of beta-amyloid precursor protein as examples

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12 December 2020

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

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12 December 2020

Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase

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12 December 2020

The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization

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12 December 2020

The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway

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12 December 2020

BAG3 and friends: co-chaperones in selective autophagy during aging and disease

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12 December 2020

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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12 December 2020

The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis

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12 December 2020

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis

1 reference

12 December 2020

Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease

1 reference

12 December 2020

10.1007/S00221-011-2932-4

Identifiers

DOI

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25 August 2017

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