(Q37427458)

20 August 2017

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title

Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors (English)

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20 August 2017

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Kristin T Jacobsen

1

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20 August 2017

Kerstin Iverfeldt

series ordinal

2

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20 August 2017

publication date

31 March 2009

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Cellular and Molecular Life Sciences

20 August 2017

published in

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20 August 2017

volume

66

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20 August 2017

issue

14

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20 August 2017

page(s)

2299-2318

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Targeting insulin-like growth factor-1 to treat Alzheimer's disease

20 August 2017

cites work

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12 December 2020

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

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12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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12 December 2020

A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism

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12 December 2020

feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping.

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12 December 2020

A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference

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12 December 2020

Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling

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12 December 2020

Sialylation enhances the secretion of neurotoxic amyloid-beta peptides

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12 December 2020

Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.

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12 December 2020

The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates

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12 December 2020

Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.

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12 December 2020

Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

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12 December 2020

A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis

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12 December 2020

Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site.

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12 December 2020

X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein

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12 December 2020

Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited

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12 December 2020

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

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12 December 2020

Reconstitution of gamma-secretase activity

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12 December 2020

The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice

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12 December 2020

Alzheimer's presenile dementia, senile dementia of Alzheimer type and Down's syndrome in middle age form an age related continuum of pathological changes

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12 December 2020

Alzheimer's disease: the amyloid cascade hypothesis

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12 December 2020

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

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12 December 2020

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

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12 December 2020

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

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12 December 2020

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

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12 December 2020

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

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12 December 2020

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability

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12 December 2020

Control of a kinesin-cargo linkage mechanism by JNK pathway kinases

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12 December 2020

The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion

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12 December 2020

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

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12 December 2020

APP processing is regulated by cytoplasmic phosphorylation

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12 December 2020

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

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12 December 2020

X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain

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12 December 2020

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

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12 December 2020

Expression and characterization of the Drosophila X11-like/Mint protein during neural development

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12 December 2020

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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12 December 2020

Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins.

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12 December 2020

Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family

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12 December 2020

The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis

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12 December 2020

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

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12 December 2020

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

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12 December 2020

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

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12 December 2020

X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

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12 December 2020

Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II.

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12 December 2020

The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

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12 December 2020

PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein

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12 December 2020

The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain

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12 December 2020

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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12 December 2020

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

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12 December 2020

Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration

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12 December 2020

The Neuronal Adaptor Protein X11β Reduces Amyloid β-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice

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12 December 2020

Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain.

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12 December 2020

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

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12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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12 December 2020

Sumoylation of amyloid precursor protein negatively regulates Abeta aggregate levels

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12 December 2020

Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides

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12 December 2020

Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein

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12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

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12 December 2020

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

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12 December 2020

The amyloid deposits in Alzheimer's disease: their nature and pathogenesis

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12 December 2020

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

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12 December 2020

Nicastrin functions as a gamma-secretase-substrate receptor

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12 December 2020

Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis

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12 December 2020

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor

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12 December 2020

Amyloid plaque core protein in Alzheimer disease and Down syndrome

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12 December 2020

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

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12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

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12 December 2020

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs

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12 December 2020

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

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12 December 2020

Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cells

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12 December 2020

Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein

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12 December 2020

Serine phosphorylation of the secreted extracellular domain of APP.

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12 December 2020

Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase

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12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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12 December 2020

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

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12 December 2020

Homo- and heterodimerization of APP family members promotes intercellular adhesion

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12 December 2020

The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid

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12 December 2020

Cleavage of amyloid beta peptide during constitutive processing of its precursor

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12 December 2020

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

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12 December 2020

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2

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12 December 2020

Amyloid precursor protein expression is upregulated in adipocytes in obesity.

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12 December 2020

Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.

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12 December 2020

The gamma-secretase complex: membrane-embedded proteolytic ensemble

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12 December 2020

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

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12 December 2020

The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport

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12 December 2020

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

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12 December 2020

Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor

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12 December 2020

Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach

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12 December 2020

Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein

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12 December 2020

Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture

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12 December 2020

Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.

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12 December 2020

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

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12 December 2020

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

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12 December 2020

Specific functions of Drosophila amyloid precursor-like protein in the development of nervous system and nonneural tissues.

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12 December 2020

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease

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12 December 2020

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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12 December 2020

Intraventricular infusions of antibodies to amyloid-beta-protein precursor impair the acquisition of a passive avoidance response in the rat.

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12 December 2020

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

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12 December 2020

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

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12 December 2020

Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2.

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12 December 2020

Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function

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12 December 2020

Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites.

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12 December 2020

In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta

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12 December 2020

aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling

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12 December 2020

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor

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12 December 2020

The molecular logic of Notch signaling--a structural and biochemical perspective.

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12 December 2020

Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail

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12 December 2020

Memory impairment and neuronal dysfunction induced by beta-amyloid protein in rats.

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

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12 December 2020

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

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12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor

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12 December 2020

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

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12 December 2020

Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid

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12 December 2020

Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP.

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12 December 2020

Effects of PS1 deficiency on membrane protein trafficking in neurons

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12 December 2020

A portrait of Alzheimer secretases--new features and familiar faces

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12 December 2020

Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

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12 December 2020

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

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12 December 2020

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.

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12 December 2020

Phosphorylation of APP695 at Thr668 decreases gamma-cleavage and extracellular Abeta

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12 December 2020

Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.

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12 December 2020

Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1

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12 December 2020

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

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12 December 2020

Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein

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12 December 2020

Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells

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12 December 2020

Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein li

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12 December 2020

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

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12 December 2020

Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by alpha- and gamma-secretase

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12 December 2020

Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein

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12 December 2020

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

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12 December 2020

Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.

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12 December 2020

PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid

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12 December 2020

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

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12 December 2020

Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats

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12 December 2020

IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways

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12 December 2020

Isolation and characterization of Drosophila presenilin homolog

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12 December 2020

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

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12 December 2020

Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.

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12 December 2020

Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain

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12 December 2020

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

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12 December 2020

Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases

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12 December 2020

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

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12 December 2020

PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.

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12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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12 December 2020

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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12 December 2020

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein

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12 December 2020

Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.

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12 December 2020

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

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12 December 2020

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors

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12 December 2020

Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its parts

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12 December 2020

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

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12 December 2020

Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system.

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12 December 2020

DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing

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12 December 2020

Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.

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12 December 2020

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

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12 December 2020

Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism

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12 December 2020

Cloning and characterization of the Drosophila presenilin homologue

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12 December 2020

RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation

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12 December 2020

Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).

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12 December 2020

Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing

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12 December 2020

KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis

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12 December 2020

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

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12 December 2020

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

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12 December 2020

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor

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12 December 2020

Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1

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12 December 2020

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

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12 December 2020

The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis

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12 December 2020

The phosphatidylinositol 3-kinase inhibitor wortmannin alters the metabolism of the Alzheimer's amyloid precursor protein.

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12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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12 December 2020

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage

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12 December 2020

10.1007/S00018-009-0020-8

Identifiers

DOI

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20 August 2017

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