(Q37997086)

26 August 2017

Promoter CpG island methylation markers in colorectal cancer: the road ahead (English)

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26 August 2017

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7

Manon van Engeland

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26 August 2017

8

Veerle Melotte

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26 August 2017

5

Gerrit A Meijer

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26 August 2017

Muriel X G Draht

1

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26 August 2017

Robert R Riedl

2

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26 August 2017

Hanneke Niessen

3

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26 August 2017

Beatriz Carvalho

4

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26 August 2017

James G Herman

6

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26 August 2017

Kim M Smits

9

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26 August 2017

language of work or name

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1 April 2012

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26 August 2017

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26 August 2017

4

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26 August 2017

2

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26 August 2017

179-194

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26 August 2017

Cancer statistics, 2009

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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

21 January 2018

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21 January 2018

Global cancer statistics

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Who to treat with adjuvant therapy in Dukes B/stage II colorectal cancer? The need for high quality pathology

21 January 2018

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Classification of colorectal cancer based on correlation of clinical, morphological and molecular features

21 January 2018

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Molecular profiling and risk stratification of adenocarcinoma of the colon

21 January 2018

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Genetic prognostic and predictive markers in colorectal cancer

21 January 2018

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Epigenetic changes in colorectal cancer.

21 January 2018

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Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis

21 January 2018

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Pharmacoepigenomics in colorectal cancer: a step forward in predicting prognosis and treatment response

21 January 2018

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Epigenetic biomarker development

21 January 2018

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DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

21 January 2018

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Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

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Colorectal cancer epigenetics: complex simplicity

21 January 2018

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Comprehensive analysis of CpG islands in human chromosomes 21 and 22

21 January 2018

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Epigenetics of cancer progression

21 January 2018

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

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Epigenetic gene silencing in cancer: the DNA hypermethylome

21 January 2018

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DNA methyltransferase 3-like affects promoter methylation of thymine DNA glycosylase independently of DNMT1 and DNMT3B in cancer cells

21 January 2018

1 reference

Formation of methylation patterns in the mammalian genome

21 January 2018

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5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

21 January 2018

1 reference

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

21 January 2018

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The essentials of DNA methylation

21 January 2018

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Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

21 January 2018

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CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future

21 January 2018

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The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

21 January 2018

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Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

21 January 2018

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Proteins that bind methylated DNA and human cancer: reading the wrong words

21 January 2018

1 reference

Insulin gene expression is regulated by DNA methylation

21 January 2018

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Genome-wide promoter analysis uncovers portions of the cancer methylome.

21 January 2018

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21 January 2018

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21 January 2018

Epigenetics in cancer

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CpG island methylator phenotype in colorectal cancer

21 January 2018

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Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer

21 January 2018

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CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

21 January 2018

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Frequent CpG island methylation in serrated adenomas of the colorectum

21 January 2018

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CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies

21 January 2018

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Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.

21 January 2018

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Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer

21 January 2018

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Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

21 January 2018

1 reference

Cancer biomarker discovery: Opportunities and pitfalls in analytical methods

21 January 2018

1 reference

Epigenetics and chemoresistance in colorectal cancer: an opportunity for treatment tailoring and novel therapeutic strategies

21 January 2018

1 reference

Molecular epidemiology: recent advances and future directions

21 January 2018

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Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology

21 January 2018

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Risk of perforation after colonoscopy and sigmoidoscopy: a population-based study

21 January 2018

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Cost-effectiveness of screening for colorectal cancer in the general population.

21 January 2018

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Molecular tests for colorectal cancer screening

21 January 2018

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Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene.

21 January 2018

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Improved fecal DNA test for colorectal cancer screening.

21 January 2018

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Sensitive digital quantification of DNA methylation in clinical samples

21 January 2018

1 reference

Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel

21 January 2018

1 reference

Fecal DNA testing for Colorectal Cancer Screening: the ColoSure™ test

21 January 2018

1 reference

Hypermethylation of SFRP2 as a potential marker for stool-based detection of colorectal cancer and precancerous lesions.

21 January 2018

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Hypermethylated SFRP2 gene in fecal DNA is a high potential biomarker for colorectal cancer noninvasive screening

21 January 2018

1 reference

Analysis of fecal DNA methylation to detect gastrointestinal neoplasia

21 January 2018

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DNA stool test for colorectal cancer: hypermethylation of the secreted frizzled-related protein-1 gene.

21 January 2018

1 reference

Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer.

21 January 2018

1 reference

N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer

21 January 2018

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GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer

21 January 2018

1 reference

Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer

21 January 2018

1 reference

Promoter DNA methylation of oncostatin m receptor-beta as a novel diagnostic and therapeutic marker in colon cancer

21 January 2018

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DNA methylation of phosphatase and actin regulator 3 detects colorectal cancer in stool and complements FIT.

21 January 2018

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Next-generation stool DNA test accurately detects colorectal cancer and large adenomas

21 January 2018

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Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer.

21 January 2018

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Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas.

21 January 2018

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DNA methylation biomarkers for blood-based colorectal cancer screening

21 January 2018

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Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer

21 January 2018

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From discovery to the clinic: the novel DNA methylation biomarker (m)SEPT9 for the detection of colorectal cancer in blood

21 January 2018

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Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions

21 January 2018

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Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer

21 January 2018

1 reference

The stool DNA test is more accurate than the plasma septin 9 test in detecting colorectal neoplasia

21 January 2018

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A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy

21 January 2018

1 reference

Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough?

21 January 2018

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Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature

21 January 2018

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Lymph node negative colorectal cancers with isolated tumor deposits should be classified and treated as stage III.

21 January 2018

1 reference

Will Rogers revisited: prospective observational study of survival of 3592 patients with colorectal cancer according to number of nodes examined by pathologists

21 January 2018

1 reference

Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review

21 January 2018

1 reference

Colorectal cancer molecular biology moves into clinical practice

21 January 2018

1 reference

The impact of lymph node yield on Duke's B and C colorectal cancer survival

21 January 2018

1 reference

The value of routine serum carcino-embryonic antigen measurement and computed tomography in the surveillance of patients after adjuvant chemotherapy for colorectal cancer

21 January 2018

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Perioperative carcinoembryonic antigen measurements to predict curability after liver resection for colorectal metastases: a prospective study

21 January 2018

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Diagnostic precision of carcinoembryonic antigen in the detection of recurrence of colorectal cancer

21 January 2018

1 reference

Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?

21 January 2018

1 reference

Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis.

21 January 2018

1 reference

Association of CHFR promoter methylation with disease recurrence in locally advanced colon cancer.

21 January 2018

1 reference

Comethylation of p16 and MGMT genes in colorectal carcinoma: correlation with clinicopathological features and prognostic value

21 January 2018

1 reference

Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis

21 January 2018

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CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer

21 January 2018

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MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers

21 January 2018

1 reference

Low microsatellite instability is associated with poor prognosis in stage C colon cancer

21 January 2018

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Distinct high-profile methylated genes in colorectal cancer

21 January 2018

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Genomic and epigenomic integration identifies a prognostic signature in colon cancer

21 January 2018

1 reference

DNA methylation predicts recurrence from resected stage III proximal colon cancer

21 January 2018

1 reference

Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability

21 January 2018

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Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases

21 January 2018

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A systematic review of treatment guidelines for metastatic colorectal cancer

21 January 2018

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Therapy for metastatic colorectal cancer

21 January 2018

1 reference

Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery

21 January 2018

1 reference

Development and Validation of Biomarker Classifiers for Treatment Selection

21 January 2018

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Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

21 January 2018

1 reference

Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy

21 January 2018

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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

21 January 2018

1 reference

Microsatellite instability in colorectal cancer

21 January 2018

1 reference

Does microsatellite instability predict the efficacy of adjuvant chemotherapy in colorectal cancer? A systematic review with meta-analysis.

21 January 2018

1 reference

Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.

21 January 2018

1 reference

Systematic review of microsatellite instability and colorectal cancer prognosis

21 January 2018

1 reference

Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy.

21 January 2018

1 reference

5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer.

21 January 2018

1 reference

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer

21 January 2018

1 reference

MGMT hypermethylation: a prognostic foe, a predictive friend

21 January 2018

1 reference

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

21 January 2018

1 reference

CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci

21 January 2018

1 reference

The power and the promise of DNA methylation markers

21 January 2018

1 reference

DNA methylation based biomarkers in non-invasive cancer screening

21 January 2018

1 reference

MS-qFRET: a quantum dot-based method for analysis of DNA methylation

21 January 2018

1 reference

Protein biomarker discovery and validation: the long and uncertain path to clinical utility

21 January 2018

1 reference

Reduced-representation methylation mapping

21 January 2018

1 reference

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers.

21 January 2018

1 reference

A genome-wide DNA methylation study in colorectal carcinoma

21 January 2018

1 reference

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

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MethyLight: a high-throughput assay to measure DNA methylation

21 January 2018

1 reference

Quantification of DNA methylation in electrofluidics chips (Bio-COBRA).

21 January 2018

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Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

21 January 2018

1 reference

Analysis of promoter CpG island hypermethylation in cancer: location, location, location!

21 January 2018

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Recommendations for biomarker identification and qualification in clinical proteomics

21 January 2018

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Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents.

21 January 2018

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A cost-effectiveness approach to the qualification and acceptance of biomarkers

21 January 2018

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The cancer biomarker problem

21 January 2018

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Cancer biomarkers: can we turn recent failures into success?

21 January 2018

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Aberrant methylation of genes in stool samples as diagnostic biomarkers for colorectal cancer or adenomas: a meta-analysis

21 January 2018

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An exploratory test for an excess of significant findings

21 January 2018

1 reference

The helicase-like transcription factor and its implication in cancer progression

21 January 2018

1 reference

Apc mice: models, modifiers and mutants

21 January 2018

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Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice

21 January 2018

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p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

21 January 2018

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REporting recommendations for tumor MARKer prognostic studies (REMARK).

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/EPI.12.9

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26 August 2017

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