(Q38007557)

26 August 2017

title

Intrinsically disordered proteins and novel strategies for drug discovery (English)

1 reference

26 August 2017

1 reference

1

Vladimir N Uversky

1 reference

26 August 2017

language of work or name

English

0 references

publication date

5 May 2012

1 reference

Expert Opinion on Drug Discovery

26 August 2017

published in

1 reference

26 August 2017

volume

7

1 reference

26 August 2017

issue

6

1 reference

26 August 2017

page(s)

475-488

1 reference

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsically disordered protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

The protein trinity--linking function and disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsically unstructured proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

What does it mean to be natively unfolded?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Natively unfolded proteins: a point where biology waits for physics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsically unstructured proteins and their functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Understanding protein non-folding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

The unfoldomics decade: an update on intrinsically disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Function and structure of inherently disordered proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Natively unfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Protein folding revisited. A polypeptide chain at the folding ? misfolding ? nonfolding cross-roads: which way to go?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

"Partly folded" state, a new equilibrium state of protein molecules: four-state guanidinium chloride-induced unfolding of beta-lactamase at low temperature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

The protein kingdom extended: ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Sequence complexity of disordered protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsic disorder and functional proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Composition Profiler: a tool for discovery and visualization of amino acid composition differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Comparing and combining predictors of mostly disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

A practical overview of protein disorder prediction methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Honing the in silico toolkit for detecting protein disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Predicting protein disorder and induced folding: from theoretical principles to practical applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Prediction of protein disorder at the domain level

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Prediction of protein disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Predicting intrinsic disorder in proteins: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Archaic chaos: intrinsically disordered proteins in Archaea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsic disorder and protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Identification and functions of usefully disordered proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Flexible nets. The roles of intrinsic disorder in protein interaction networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

The interplay between structure and function in intrinsically unstructured proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

The role of structural disorder in the function of RNA and protein chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Structural disorder throws new light on moonlighting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsic disorder in cell-signaling and cancer-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Insights into the structure and dynamics of unfolded proteins from nuclear magnetic resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Coupled folding and binding with alpha-helix-forming molecular recognition elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Disorder and sequence repeats in hub proteins and their implications for network evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Flexible nets of malleable guardians: intrinsically disordered chaperones in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsic disorder in proteins associated with neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Unfoldomics of human genetic diseases: illustrative examples of ordered and intrinsically disordered members of the human diseasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Is there a biological cost of protein disorder? Analysis of cancer-associated mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Structural disorder in amyloid fibrils: its implication in dynamic interactions of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Mechanistic basis of enzyme-targeted drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

The (un)targeted cancer kinome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Protein kinase biochemistry and drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Principles for modulation of the nuclear receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Orphan nuclear receptor modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Nuclear receptors: overview and classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Steroid and nuclear receptors. Villefranche-sur-Mer, France, May 25-27, 1999.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Ion channels as drug targets: the next GPCRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Membrane transporters in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Biochemical mechanisms of drug action: what does it take for success?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Drugs, their targets and the nature and number of drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Strategies for targeting protein-protein interactions with synthetic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

A hot spot of binding energy in a hormone-receptor interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Identification of small molecule binding sites within proteins using phage display technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Protein-protein interactions in receptor activation and intracellular signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Drugs for 'protein clouds': targeting intrinsically disordered transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Activation and activities of the p53 tumour suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Rational drug design via intrinsically disordered protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

ANCHOR: web server for predicting protein binding regions in disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Prediction of protein binding regions in disordered proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Local structural disorder imparts plasticity on linear motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Preformed structural elements feature in partner recognition by intrinsically unstructured proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

c-Myc target genes involved in cell growth, apoptosis, and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsically disordered proteins are potential drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-Myc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Low molecular weight inhibitors of Myc-Max interaction and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Improved low molecular weight Myc-Max inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Intrinsically disordered proteins may escape unwanted interactions via functional misfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Structural neurology: are seeds at the root of neuronal degeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

A molecular tweezer for lysine and arginine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Small molecule inhibitors of alpha-synuclein filament assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Mysterious oligomerization of the amyloidogenic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Opinion: What is the role of protein aggregation in neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Interaction of thioflavin T with amyloid fibrils: fluorescence quantum yield of bound dye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Analyzing thioflavin T binding to amyloid fibrils by an equilibrium microdialysis-based technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

Interaction of Thioflavin T with Amyloid Fibrils: Stoichiometry and Affinity of Dye Binding, Absorption Spectra of Bound Dye

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.686489

10.1517/17460441.2012.686489

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference