(Q38067621)

28 August 2017

1 reference

title

Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies (English)

1 reference

28 August 2017

J Fraczek

1

1 reference

28 August 2017

J Bolleyn

2

1 reference

28 August 2017

T Vanhaecke

3

1 reference

28 August 2017

V Rogiers

4

1 reference

28 August 2017

M Vinken

5

1 reference

28 August 2017

publication date

15 December 2012

1 reference

28 August 2017

published in

Archives of Toxicology

1 reference

28 August 2017

volume

87

1 reference

28 August 2017

issue

4

1 reference

28 August 2017

page(s)

577-610

1 reference

https://scigraph.springernature.com/pub.10.1007/s00204-012-0983-3

28 August 2017

exact match

0 references

cites work

New nomenclature for chromatin-modifying enzymes

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Purpose-driven biomaterials research in liver-tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Liver-enriched HNF-3 alpha and ubiquitous factors interact with the human transferrin gene enhancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Preservation of the synthetic and metabolic capacity of isolated human hepatocytes by coculture with human biliary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

An alternative promoter contributes to tissue- and inducer-specific expression of the rat UDP-glucuronosyltransferase 1A6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Temporal gene expression analysis of monolayer cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Exploratory drug safety: a discovery strategy to reduce attrition in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone deacetylase inhibitors as anti-neoplastic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

DNA methylation and gene silencing in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Genomics and proteomics analysis of cultured primary rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Collagen gel sandwich and immobilization cultures of rat hepatocytes: Problems encountered in expressing glutathione S-transferase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Cell morphology, albumin secretion and glutathione S-Transferase expression in collagen gel sandwich and immobilization cultures of rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Microfabrication of hepatocyte/fibroblast co-cultures: role of homotypic cell interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Time course of cytochromes P450 decline during rat hepatocyte isolation and culture: effect of L-NAME.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Characterization of an enhancer element in the human apolipoprotein C-III gene that regulates human apolipoprotein A-I gene expression in the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Members of the CAAT/enhancer-binding protein, hepatocyte nuclear factor-1 and nuclear factor-1 families can differentially modulate the activities of the rat alpha-fetoprotein promoter and enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Anticancer activities of histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Rational combinations using HDAC inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Hepatocyte nuclear factor 1 and C/EBP are essential for the activity of the human apolipoprotein B gene second-intron enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Isolation and characterization of the human UGT2B7 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Hepatocyte nuclear factor 1 binds to and transactivates the human but not the rat CYP7A1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Mammalian DNA methyltransferases: a structural perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

AdoMet-dependent methylation, DNA methyltransferases and base flipping

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Lysine acetylation targets protein complexes and co-regulates major cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Small noncoding RNAs: biogenesis, function, and emerging significance in toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Epigenetics and microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Zn(II)-dependent histone deacetylase inhibitors: suberoylanilide hydroxamic acid and trichostatin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The coculture: a system for studying the regulation of liver differentiation/proliferation activity and its control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone deacetylases (HDACs): characterization of the classical HDAC family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Which in vitro models could be best used to study hepatocyte polarity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The human Mi-2/NuRD complex and gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The price of innovation: new estimates of drug development costs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Opportunities for an alternative integrating testing strategy for carcinogen hazard assessment?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Prolonged expression of biotransformation activities of rat hepatocytes co-cultured with established cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Drug metabolizing enzymes in rat hepatocytes co-cultured with cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Co-cultures of hepatocytes with epithelial-like cell lines: expression of drug-biotransformation activities by hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Rat hepatocytes cultured on a monkey kidney cell line: Expression of biotransformation and hepatic metabolic activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Major phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Characterization of the secreted proteome of rat hepatocytes cultured in collagen sandwiches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Identification of functional regulatory regions of the connexin32 gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

cis-acting elements and transcription factors involved in the promoter activity of the human factor VIII gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Isolation of the UDP-glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

HDAC inhibitors: clinical update and mechanism-based potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Acetylation and deacetylation of non-histone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

In vitro evaluation of potential hepatotoxicity induced by drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Microfluidic platforms for hepatocyte cell culture: new technologies and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Cellular interactions promote tissue-specific function, biomatrix deposition and junctional communication of primary cultured hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Liver-specific expression of the human factor VII gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Pluripotent stem cell derived hepatocyte like cells and their potential in toxicity screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Tissue specific differences in the regulation of the UDP glucuronosyltransferase 2B17 gene promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Cytochrome p450 and chemical toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

HNF1 alpha activates the rat UDP glucuronosyltransferase UGT2B1 gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Liver enriched transcription factors and differentiation of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone deacetylases--an important class of cellular regulators with a variety of functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Inhibition of hepatocyte growth factor production in human fibroblasts by ursodeoxycholic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Regulation of cytochrome P-450 CYPIA1 gene expression and proto-oncogene expression by growth factors in primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Characterization of the 5'-flanking region of the gene for the alpha chain of human fibrinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Biological functions of microRNAs: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Matrigel: a complex protein mixture required for optimal growth of cell culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

HNF4α--role in drug metabolism and potential drug target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Mechanisms controlling growth of hepatocytes in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Interplay between microRNAs and the epigenetic machinery: an intricate network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Maintenance of differentiated rat hepatocytes in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

De novo CpG island methylation in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Diffusion in tissue cultures on gas-permeable and impermeable supports

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Regulation of CYP1A2 by histone deacetylase inhibitors in mouse hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Tissue-specific and de novo promoter methylation of the mouse glucose transporter 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional regulation of cytochrome p450 genes by the nuclear receptor hepatocyte nuclear factor 4-alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Zonation of parenchymal and nonparenchymal metabolism in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The FoxA factors in organogenesis and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Microfluidics for drug discovery and development: from target selection to product lifecycle management

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Microscale culture of human liver cells for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

3D hepatic cultures simultaneously maintain primary hepatocyte and liver sinusoidal endothelial cell phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Mitogenic and metabolic effects of type I IGF receptor overexpression in insulin receptor-deficient hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

A comparative study of genome-wide transcriptional profiles of primary hepatocytes in collagen sandwich and monolayer cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Changes in cellular distribution of connexins 32 and 26 during formation of gap junctions in primary cultures of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Can the pharmaceutical industry reduce attrition rates?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Epigenetics and cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Plasticity and expanding complexity of the hepatic transcription factor network during liver development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Identification of tissue-specific microRNAs from mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Discovering networks of perturbed biological processes in hepatocyte cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transactivation of the rat CYP2C13 gene promoter involves HNF-1, HNF-3, and members of the orphan receptor subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Regulating histone acetyltransferases and deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Merging bioreactor technology with 3D hepatocyte-fibroblast culturing approaches: Improved in vitro models for toxicological applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Multiple hepatic trans-acting factors are required for in vitro transcription of the human alpha-1-antitrypsin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional regulation of the CYP2B1 and CYP2B2 genes by C/EBP-related proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Structure and dynamic behavior of nucleosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

New insights into functional aspects of liver morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional regulation of the apolipoprotein AI gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The hepatic microvascular system in health and its response to toxicants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Molecular analysis of the distal enhancer of the mouse alpha-fetoprotein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Towards an extended functional hepatocyte in vitro culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Phenobarbital suppresses growth and accelerates restoration of differentiation markers of primary culture rat hepatocytes in the chemically defined hepatocyte growth medium containing hepatocyte growth factor and epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Long-term maintenance of hepatocyte functional activity in co-culture: requirements for sinusoidal endothelial cells and dexamethasone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Effect of increasing selenite concentrations, vitamin E supplementation and different fetal calf serum content on GPx1 activity in primary cultured rabbit hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Analysis of gene expression profile induced by hepatocyte nuclear factor 4alpha in hepatoma cells using an oligonucleotide microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Functional activity of human hepatoma cells transfected with adenovirus-mediated hepatocyte nuclear factor (HNF)-4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Adenovirus-transferred HNF-3 gamma conserves some liver functions in primary cultured hepatocytes of adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Shear stress induces hepatocyte PAI-1 gene expression through cooperative Sp1/Ets-1 activation of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

C/EBPs: recipients of extracellular signals through proteome modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Secretion of albumin and induction of CYP1A2 and CYP3A4 in novel three-dimensional culture system for human hepatocytes using micro-space plate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Expression levels of drug-metabolizing enzyme, transporter, and nuclear receptor mRNAs in a novel three-dimensional culture system for human hepatocytes using micro-space plates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone deacetylases as transcriptional activators? Role reversal in inducible gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Deacetylase inhibitors - focus on non-histone targets and effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Control of pancreas and liver gene expression by HNF transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The histone deacetylase inhibitor trichostatin a has genotoxic effects in human lymphoblasts in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Nanofabrication of nonfouling surfaces for micropatterning of cell and microtissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Activation of signalling pathways during hepatocyte isolation: relevance to toxicology in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Inhibition of NF-kappaB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The CYP2B1 proximal promoter contains a functional C/EBP regulatory element

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Managing the challenge of chemically reactive metabolites in drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Bioartificial liver systems: current status and future perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Chemical biology of histone acetyltransferase natural compounds modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Dioxin receptor and C/EBP regulate the function of the glutathione S-transferase Ya gene xenobiotic response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional regulation of the human CYP2A6 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Making better drugs: Decision gates in non-clinical drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Activation of PPARgamma coactivator-1 through transcription factor docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Polyelectrolyte nano-scaffolds for the design of layered cellular architectures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Interplay of an original combination of factors: C/EBP, NFY, HNF3, and HNF1 in the rat aldolase B gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

DNA hypermethylation as a chemotherapy target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Two CCAAT/enhancer binding protein sites in the cytochrome P4503A1 locus. Potential role in the glucocorticoid response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Archaeal histones and the origin of the histone fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Chromatin modifier enzymes, the histone code and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Solving the Dnmt2 enigma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Why drugs fail--a study on side effects in new chemical entities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Chapter 4 Preparation of Isolated Rat Liver Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Micro RNAs: tiny sequences with enormous potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Glucagon receptor signaling is essential for control of murine hepatocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Time for a consistent approach to preparing and culturing hepatocytes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

A shifting paradigm: histone deacetylases and transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Tissue-specific and androgen-repressible regulation of the rat dehydroepiandrosterone sulfotransferase gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

MicroRNAs control hepatocyte proliferation during liver regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Type I protein C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein C gene promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The language of covalent histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Epigenetics, DNA methylation, and chromatin modifying drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

DNA methylation and demethylation probed by small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone deacetylase inhibitors: clinical implications for hematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Cell culture and life support system for microbioreactor and bioassay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

ADDME--Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Developmental appearance of transcription factors that regulate liver-specific expression of the aldolase B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Human hepatic stem cell and maturational liver lineage biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Effects of cell culture conditions on primary rat hepatocytes-cell morphology and differential gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional control of the rat hepatic CYP2E1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Differential stabilization of cytochrome P-450 isoenzymes in primary cultures of adult rat liver parenchymal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Epigenetic interplay between histone modifications and DNA methylation in gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional- and post-transcriptional-dependent regulation of glutathione S-transferase expression in rat hepatocytes as a function of culture conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Involvement of cell junctions in hepatocyte culture functionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Biology and pathobiology of gap junctional channels in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

MicroRNAs: synthesis, mechanism, function, and recent clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

In vivo regulation of murine CYP7A1 by HNF-6: a novel mechanism for diminished CYP7A1 expression in biliary obstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Nanometric self-assembling peptide layers maintain adult hepatocyte phenotype in sandwich cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone deacetylase inhibitors: molecular mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

cDNA microarray analysis in hepatocyte differentiation in Huh 7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional regulation of the phosphoenolpyruvate carboxykinase gene by cooperation between hepatic nuclear factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Functional association between CBP and HNF4 in trans-activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Activation of CCAAT/enhancer-binding protein (C/EBP) alpha expression by C/EBP beta during adipogenesis requires a peroxisome proliferator-activated receptor-gamma-associated repression of HDAC1 at the C/ebp alpha gene promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Phenotypic characterization of rat hepatoma cell lines and lineage-specific regulation of gene expression by differentiation agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Sequential Exposure to Cytokines Reflecting Embryogenesis: The Key for in vitro Differentiation of Adult Bone Marrow Stem Cells into Functional Hepatocyte-like Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Glucocorticoid Ligands Specify Different Interactions with NF-κB by Allosteric Effects on the Glucocorticoid Receptor DNA Binding Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Spheroid formation and expression of liver-specific functions of human hepatocellular carcinoma-derived FLC-4 cells cultured in lactose-silk fibroin conjugate sponges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Re-expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Transcriptional Activation of CYP2C9, CYP1A1, and CYP1A2 by Hepatocyte Nuclear Factor 4 Requires Coactivators Peroxisomal Proliferator Activated Receptor- Coactivator 1 and Steroid Receptor Coactivator 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Microfibrillated Cellulose Sheets Coating Oxygen-Permeable PDMS Membranes Induce Rat Hepatocytes 3D Aggregation into Stably-Attached 3D Hemispheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-012-0983-3

10.1007/S00204-012-0983-3

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

28 August 2017

1000685935

0 references

1 reference