(Q38088256)

28 August 2017

title

Developing new antibacterials through natural product research (English)

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28 August 2017

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Herbert A Kirst

1

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28 August 2017

language of work or name

English

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publication date

12 March 2013

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

volume

8

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28 August 2017

issue

5

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28 August 2017

page(s)

479-493

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Thoughts and facts about antibiotics: where we are now and where we are heading

28 August 2017

cites work

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Critical shortage of new antibiotics in development against multidrug-resistant bacteria-Time to react is now.

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Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

21 January 2018

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Antibiotics versus resistant bacteria: a continual challenge

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Origins and evolution of antibiotic resistance

21 January 2018

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The importance of new companies for drug discovery: origins of a decade of new drugs

21 January 2018

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Drug discovery management, small is still beautiful: Why a number of companies get it wrong

21 January 2018

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Antibiotics in the clinical pipeline in 2011.

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Antibiotic discovery in the twenty-first century: current trends and future perspectives

21 January 2018

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Antibiotics in development targeting protein synthesis

21 January 2018

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Novel classes of antibiotics or more of the same?

21 January 2018

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Antibiotics for emerging pathogens

21 January 2018

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FDA under pressure to relax drug rules.

21 January 2018

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Fix the antibiotics pipeline.

21 January 2018

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Forgotten antibiotics: an inventory in Europe, the United States, Canada, and Australia

21 January 2018

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Daptomycin: from the mountain to the clinic, with essential help from Francis Tally, MD.

21 January 2018

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Natural products in drug discovery: present status and perspectives

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Recent advances in the chemistry and biology of naturally occurring antibiotics

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.779666

The oxazolidinones: past, present, and future.

21 January 2018

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Are pleuromutilin antibiotics finally fit for human use?

21 January 2018

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Platensimycin and platencin: promising antibiotics for future application in human medicine

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Improving known classes of antibiotics: an optimistic approach for the future

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Will new antimicrobials overcome resistance among Gram-negatives?

21 January 2018

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Recent derivatives from smaller classes of fermentation-derived antibacterials

21 January 2018

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Antimicrobial activity of the investigational pleuromutilin compound BC-3781 tested against Gram-positive organisms commonly associated with acute bacterial skin and skin structure infections

21 January 2018

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Pleuromutilin and its derivatives-the lead compounds for novel antibiotics

21 January 2018

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A click chemistry approach to pleuromutilin derivatives, part 2: conjugates with acyclic nucleosides and their ribosomal binding and antibacterial activity.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.779666

A scalable synthesis of 2S-hydroxymutilin via a modified Rubottom oxidation

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.779666

A concise synthesis of the molecular framework of pleuromutilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus Clitopilus passeckerianus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Chapter 20. Biosynthesis and genetic engineering of lipopeptides in Streptomyces roseosporus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

In vitro and in vivo characterization of CB-183,315, a novel lipopeptide antibiotic for treatment of Clostridium difficile

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Isolation and identification of lipopeptide antibiotics from Paenibacillus elgii B69 with inhibitory activity against methicillin-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Polymyxins and their novel derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Structure--activity relationships of polymyxin antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Battacin (Octapeptin B5), a new cyclic lipopeptide antibiotic from Paenibacillus tianmuensis active against multidrug-resistant Gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Isolation and characterization of peptide antibiotics LI-F04 and polymyxin B6 produced by Paenibacillus polymyxa strain JSa-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Efficacy of LFF571 in a hamster model of Clostridium difficile infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Total synthesis and complete structural assignment of thiocillin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Discovery and development of lantibiotics; antimicrobial agents that have significant potential for medical application.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Fundamental functionality: recent developments in understanding the structure-activity relationships of lantibiotic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Strategies for the isolation and characterization of antibacterial lantibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Increasing the success rate of lantibiotic drug discovery by Synthetic Biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Discovery, biosynthesis, and engineering of lantipeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

New horizons for host defense peptides and lantibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Developing a drug-like natural product library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

The impact of natural products upon modern drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Modeling cellular pharmacokinetics of 14- and 15-membered macrolides with physicochemical properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

The influence of lipophilicity in drug discovery and design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Lipophilicity in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Charting, navigating, and populating natural product chemical space for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Drug-like properties: guiding principles for the design of natural product libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

The antibiotics in the chemical space

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Novel chemical space exploration via natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Natural-product-derived fragments for fragment-based ligand discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

A minimalist fragment approach for the design of natural-product-like synthetic scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Structure-based design of anti-infectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Application of SBDD to the discovery of new antibacterial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

On the specificity of antibiotics targeting the large ribosomal subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Antibiotics that target protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Simulating activity of the bacterial ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

New β-lactam antibiotics and β-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

The history of the tetracyclines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

An overview of highly optically pure chloramphenicol bases: applications and modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Genetics of Streptomyces fradiae and tylosin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Combinatorial biosynthesis of polyketides--a perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Bioactive compounds synthesized by non-ribosomal peptide synthetases and type-I polyketide synthases discovered through genome-mining and metagenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

The chemical biology of modular biosynthetic enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Bioinformatic perspectives on NRPS/PKS megasynthases: advances and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

A turning point for natural product discovery--ESF-EMBO research conference: synthetic biology of antibiotic production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Role of bioinformatics in the development of new antibacterial therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Microbial drug discovery: 80 years of progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Antibacterial Agents from Actinomycetes - A Review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Rare actinomycetes: a potential storehouse for novel antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Current approaches to exploit actinomycetes as a source of novel natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Renaissance in antibacterial discovery from actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Drug discovery from uncultivable microorganisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

How to discover new antibiotics: harvesting the parvome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Approaches to capturing and designing biologically active small molecules produced by uncultured microbes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Rediscovery of known natural compounds: nuisance or goldmine?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

An introduction to natural products isolation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Dereplication of microbial natural products by LC-DAD-TOFMS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Confronting the challenges of natural product-based antifungal discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

The spinosyn family of insecticides: realizing the potential of natural products research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Ancient fungi found in deep-sea mud.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

New classes of antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

New screens and targets in antibacterial drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Automated design of ligands to polypharmacological profiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Chemoselective enrichment for natural products discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Rapid test for distinguishing membrane-active antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Evolving trends in the dereplication of natural product extracts. 2. The isolation of chrysaibol, an antibiotic peptaibol from a New Zealand sample of the mycoparasitic fungus Sepedonium chrysospermum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Metagenomic analyses: past and future trends

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

The great screen anomaly--a new frontier in product discovery through functional metagenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Genome-based bioprospecting of microbes for new therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Antimicrobials, drug discovery, and genome mining

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Modern approaches in the search for new lead antiparasitic compounds from higher plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Marine bacterial sources of bioactive compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Bioprospecting microbial natural product libraries from the marine environment for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Targeting virulence traits: potential strategies to combat extraintestinal pathogenic E. coli infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Prevention of bacterial adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Non-antibiotic strategies for sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Immunotherapies in infectious diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

New approaches for treating staphylococcal biofilm infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Targeting iron assimilation to develop new antibacterials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

How and why bacteria talk to each other

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Antibiotics as signal molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Non-genetic mechanisms communicating antibiotic resistance: rethinking strategies for antimicrobial drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Engineering antibiotic production and overcoming bacterial resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Chemical inhibitors of the type three secretion system: disarming bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Novel agents to inhibit microbial virulence and pathogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Antibiotics: natural products essential to human health

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Current challenges in the discovery of novel antibacterials from microbial natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Synthesis of the Pyridine Core of Cyclothiazomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Synthesis: A constructive debate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.779666

Tiacumicins, a novel complex of 18-membered macrolides. II. Isolation and structure determination

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.40.575

Structure of althiomycin

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.286

Identifiers

DOI

10.1517/17460441.2013.779666

1 reference

28 August 2017

1 reference